TARGETBRAIN

Targeting Brain Inflammation For Improved Functional Recovery in Acute Neurodegenerative Disorders

Coordinatore	more  Organization address address: Paradisgatan 5c city: LUND postcode: 22100 contact info Titolo: Prof. Nome: Zaal Cognome: Kokaia Email: send email Telefono: +46 46 2220276 Fax: +46 46 2220560
Nazionalità Coordinatore	Non specificata
Sito del progetto	http://www.targetbrain.eu/
Totale costo	15˙716˙317 €
EC contributo	11˙989˙162 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-
Anno di inizio	2011
Periodo (anno-mese-giorno)	2011-12-01   -   2016-11-30

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	LUNDS UNIVERSITET  Organization address address: Paradisgatan 5c city: LUND postcode: 22100 contact info Titolo: Prof. Nome: Zaal Cognome: Kokaia Email: send email Telefono: +46 46 2220276 Fax: +46 46 2220560	SE (LUND)	coordinator	2˙132˙786.00
2	WEIZMANN INSTITUTE OF SCIENCE  Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 contact info Titolo: Ms. Nome: Talia Cognome: Tzahor Email: send email Telefono: +972 8 934 4026 Fax: +972 8 934 4165	IL (REHOVOT)	participant	1˙594˙223.00
3	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Ms. Nome: Ines Cognome: Scholz Email: send email Telefono: +41 44 635 3701 Fax: +41 44 635 6883	CH (ZURICH)	participant	1˙461˙540.00
4	GOETEBORGS UNIVERSITET  Organization address address: VASAPARKEN city: GOETEBORG postcode: 405 30 contact info Titolo: Prof. Nome: Milos Cognome: Pekny Email: send email Telefono: +46 31 7863269 Fax: +46 31 416108	SE (GOETEBORG)	participant	1˙461˙510.00
5	MAX PLANCK GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V.  Organization address address: Hofgartenstrasse 8 city: MUENCHEN postcode: 80539 contact info Titolo: Prof. Nome: Mathias Cognome: Hoehn Email: send email Telefono: +49 221 4726315 Fax: +49 221 4726337	DE (MUENCHEN)	participant	1˙455˙945.00
6	ST GEORGE'S HOSPITAL MEDICAL SCHOOL  Organization address address: Cranmer Terrace city: LONDON postcode: SW17 0RE contact info Titolo: Dr. Nome: Claudia Cognome: Eder Email: send email Telefono: +44 20 8725 4937 Fax: +44 20 8266 6719	UK (LONDON)	participant	1˙431˙600.00
7	UNIVERSITA VITA-SALUTE SAN RAFFAELE  Organization address address: Via Olgettina 58 city: MILANO postcode: 20132 contact info Titolo: Dr. Nome: Maria Rosa Cognome: Pedrazzi Email: send email Telefono: +39 02 26434845 Fax: +39 02 26434717	IT (MILANO)	participant	1˙364˙200.00
8	GEMAC  Organization address address: LIEU DIT BERGANTON city: SAINT JEAN D ILLAC postcode: 33127 contact info Titolo: Dr. Nome: Marie Claire Cognome: Goichon Email: send email Telefono: +33 5 57 544 544	FR (SAINT JEAN D ILLAC)	participant	587˙378.00
9	IMMUNOBRAIN LTD  Organization address address: PEKRIS STREET 3 city: REHOVOT contact info Titolo: Dr. Nome: Eti Cognome: Yoles Email: send email Telefono: 972546000000 Fax: 972747000000	IL (REHOVOT)	participant	499˙980.00
10	PRONEURON BIOTHECHNOLOGIES (ISRAEL) LTD  Organization address address: AHUZA STREET 45 city: RAANANA postcode: 43208 contact info Titolo: Dr. Nome: Eti Cognome: Yoles Email: send email Telefono: +972 54 5660491	IL (RAANANA)	participant	0.00

Mappa

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 Obiettivo del progetto (Objective)

'In acute neurodegenerative disorders, following a sudden insult, neurons are rapidly damaged and usually die but cellular loss can occur hours and days thereafter. These diseases cause massive morbidity and mortality and tremendous economic and societal burden, especially ischemic stroke, which is a leading cause of death and disability with no effective treatment to promote recovery. The brain responds to a stroke, i.e., occlusion of a cerebral artery, with an inflammatory process characterized by rapid activation of resident cells including microglia and astrocytes, production of proinflammatory mediators, and infiltration of various types of immune cells. Recent studies have suggested that the local inflammation is not only detrimental but can also be beneficial for the repair process. Our proposal unites 7 leading academic teams and 2 experienced SMEs and aims to develop a pre-clinical protocol for immunomodulation leading to enhancement of cellular plasticity and improved functional recovery in stroke patients. To achieve this goal we will study the temporal and spatial role of inflammatory cells in stroke-induced brain damage and determine the action of inflammatory cells in the activation and support of regenerative processes, including the formation of new neurons from endogenous and transplanted neural stem cells (NSCs). We will investigate the ability of transplanted NSCs to modulate the inflammatory response and to affect the characteristics of the stroke-induced lesion and subsequent recovery. The overriding social objective of our project is to develop a novel therapeutic strategy which will shorten the recovery phase, minimize the motor impairments, and improve the patients’quality of life after stroke.'

Introduzione (Teaser)

Stroke affects 15 million people globally, out of which 5 million die and 5 million are permanently disabled. EU-funded researchers are working on finding solutions for facilitating recovery after stroke.