SOGVID

Survival in Oesophageal and Gastric Cancer Patients and Vitamin D

Coordinatore	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN    more  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: +353 1 8961942 Fax: +353 17071633
Nazionalità Coordinatore	Ireland [IE]
Totale costo	100˙000 €
EC contributo	100˙000 €
Programma	FP7-PEOPLE Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013)
Code Call	FP7-PEOPLE-2013-CIG
Funding Scheme	MC-CIG
Anno di inizio	2014
Periodo (anno-mese-giorno)	2014-03-01   -   2018-02-28

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN  Organization address address: College Green - city: DUBLIN postcode: 2 contact info Titolo: Ms. Nome: Deirdre Cognome: Savage Email: send email Telefono: +353 1 8961942 Fax: +353 17071633	IE (DUBLIN)	coordinator	100˙000.00

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 Obiettivo del progetto (Objective)

'This project aims to investigate the role of vitamin D status in survival of patients diagnosed with oesophageal or gastric cancer. The ultimate goal of the project is to help inform cancer treatment and improve survival in these patients.

Both oesophageal and gastric cancer have exceptionally poor prognosis, with a 5-year survival of only 15-20%. Moreover, little improvement in survival has been made in either cancer type. Observational and ecological studies have investigated associations between vitamin D proxies (e.g. vitamin D dietary intake, sunshine hours or UVB irradiance) and upper gastrointestinal cancers. These studies largely show poorer prognosis in cancer patients with lower estimated vitamin D levels. Vitamin D deficiency is prevalent in Europe and the investigation of any potential detrimental effects of vitamin D deficiency is of major significance for the population. To date, no well-designed study has investigated the relationship between post-diagnostic circulating 25-hydroxyvitamin D (25-OHD, the best indicator of vitamin D status) and prognosis in oesophageal cancer patients. Therefore, the main aim of this proposal is to explore the relationship between 25-OHD concentration at the time of diagnosis and survival in oesophageal cancer patients. We also propose to investigate, for the first time in Caucasians, the relationship between 25-OHD and survival in gastric cancer patients. Furthermore, we seek to assess the mechanism of these associations, as understanding the biological pathway could add evidence in support of their causality. The principle way that vitamin D exerts its biological action is by binding to the vitamin D receptor (VDR). Therefore, presence of functioning VDR is crucial for its downstream effects, such as expression of E-cadherin (CDH1). To address this, we will assess the expression of the VDR and CDH1 genes in tissue, and we will genotype common polymorphisms in VDR gene that are known to affect its function.'