FMTXCT

Hybrid Fluorescence Molecular Tomography and X-ray Computed Tomography system and method

Coordinatore	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH    more  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: 498932000000 Fax: 498932000000
Nazionalità Coordinatore	Germany [DE]
Sito del progetto	http://www.fmt-xct.eu
Totale costo	5˙839˙676 €
EC contributo	4˙512˙141 €
Programma	FP7-HEALTH Specific Programme "Cooperation": Health
Code Call	FP7-HEALTH-2007-A
Funding Scheme	CP-FP
Anno di inizio	2008
Periodo (anno-mese-giorno)	2008-03-01   -   2012-08-31

 Partecipanti

#	participant	country	role	EC contrib. [€]
1	HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH  Organization address address: Ingolstaedter Landstrasse 1 city: MUENCHEN postcode: 85764 contact info Titolo: Dr. Nome: Juergen Cognome: Ertel Email: send email Telefono: 498932000000 Fax: 498932000000	DE (MUENCHEN)	coordinator	0.00
2	COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES  Organization address address: RUE LEBLANC 25 city: PARIS 15 postcode: 75015 contact info Titolo: Mr. Nome: Olivier Cognome: Leroy Email: send email Telefono: 33169867807 Fax: +33 1 69 86 78 07	FR (PARIS 15)	participant	0.00
3	CT Imaging GmbH  Organization address address: Henkestrasse, 91 city: ERLANGEN postcode: 91052 contact info Titolo: Ms. Nome: Mandy Cognome: Landmann Email: send email Telefono: +49 9131 973 100 Fax: +49 9131 973 1010	DE (ERLANGEN)	participant	0.00
4	FOUNDATION FOR RESEARCH AND TECHNOLOGY HELLAS  Organization address address: N PLASTIRA STR 100 city: HERAKLION postcode: 70013 contact info Titolo: Dr. Nome: Jorge Cognome: Ripoll Email: send email Telefono: 3028103918 Fax: +30 2810 391805	EL (HERAKLION)	participant	0.00
5	FUNDACION PARA LA INVESTIGACION BIOMEDICA DEL HOSPITAL GREGORIO MARANON  Organization address address: c/ Dr. Esquerdo city: MADRID postcode: 28007 contact info Titolo: Mr. Nome: Jesús Maria Cognome: Calavia Balduz Email: send email Telefono: +34 91 586 7058 Fax: +34 91 400 8156	ES (MADRID)	participant	0.00
6	UNIVERSIDAD CARLOS III DE MADRID  Organization address address: CALLE MADRID 126 city: GETAFE (MADRID) postcode: 28903 contact info Titolo: Ms. Nome: Regina Cognome: Garcia Beato Email: send email Telefono: +34 91 6249931 Fax: +34 91 6249330	ES (GETAFE (MADRID))	participant	0.00
7	UNIVERSITAET ZUERICH  Organization address address: Raemistrasse 71 city: ZURICH postcode: 8006 contact info Titolo: Prof. Nome: Markus Cognome: Rudin Email: send email Telefono: +4144 633 76 04 Fax: 41446331187	CH (ZURICH)	participant	0.00
8	UNIVERSITY COLLEGE LONDON  Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT contact info Titolo: Mr. Nome: Kent Cognome: Lee Email: send email Telefono: 442077000000 Fax: 442077000000	UK (LONDON)	participant	0.00

Mappa

 Word cloud

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 Obiettivo del progetto (Objective)

'This proposal offers to combine X-ray CT (XCT) and Fluorescence Molecular Tomography (FMT) into a hybrid, quantitative system and method. The project builds on state-of the-art knowledge that only recently became available in different European states as represented by the partners herein. In return it delivers the first such hybrid system worldwide. The system will operate by 1) co-registering XCT images with highly performing FMT images for merging anatomical, functional and molecular contrast and by 2) combining XCT information into the FMT inversion to provide a system with superior imaging performance. XCT-based correction, as explained in this proposal, can improve FMT performance in a more radical way than corresponding “correction methods” used for improving PET or SPECT images. In this way FMT-XCT can reach the imaging accuracy of radio-nuclei-based tomography hybrid systems. By using fluorescence, FMT-XCT can then enable high flexibility in targeting physiology and molecular function, especially in multi-spectral mode, and high dissemination potential because virtually any biomedical laboratory has access to fluorescence reporting, compared to radio-nuclei based research that requires access to radiochemistry and cyclotron facilities. FMT-XCT aims in advancing small animal imaging and drug discovery with a view towards the clinical application on non-invasive breast cancer imaging. For this reason, focus herein is given to imaging breast cancer and response to therapy. Overall the technology is ideally suited for commercial translation and has the potential to become the method of choice for in-vivo imaging in most biomedical laboratories and in select clinical applications. While it appreciates the value of nuclear imaging methods, this proposal will hopefully raise the funding necessary to establish on European ground a new potent paradigm of in-vivo imaging with high dissemination and application potential and large social and health-care impact .'

Introduzione (Teaser)

Accurate diagnosis is one issue; appropriate therapy is another. Together, they are the key to eradication of many diseases. With EU funding, researchers have pioneered a hybrid imaging technique to achieve both ambitious objectives.