MAGICPAH
Molecular Approaches and MetaGenomic Investigations for optimizing Clean-up of PAH contaminated sites
| Coordinatore | HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
Organization address
address: Inhoffenstrasse 7 contact info |
| Nazionalità Coordinatore | Germany [DE] |
| Totale costo | 4˙515˙496 € |
| EC contributo | 2˙997˙137 € |
| Programma | FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology |
| Code Call | FP7-KBBE-2009-3 |
| Funding Scheme | CP-FP |
| Anno di inizio | 2010 |
| Periodo (anno-mese-giorno) | 2010-04-01 - 2014-03-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
HELMHOLTZ-ZENTRUM FUER INFEKTIONSFORSCHUNG GMBH
Organization address
address: Inhoffenstrasse 7 contact info |
DE (BRAUNSCHWEIG) | coordinator | 435˙890.00 |
| 2 |
AARHUS UNIVERSITET
Organization address
address: Nordre Ringgade 1 contact info |
DK (AARHUS C) | participant | 320˙160.00 |
| 3 |
HELMHOLTZ-ZENTRUM FUER UMWELTFORSCHUNG GMBH - UFZ
Organization address
address: Permoser Strasse 15 contact info |
DE (LEIPZIG) | participant | 305˙475.00 |
| 4 |
CONSIGLIO NAZIONALE DELLE RICERCHE
Organization address
address: Piazzale Aldo Moro 7 contact info |
IT (ROMA) | participant | 303˙534.00 |
| 5 |
BANGOR UNIVERSITY
Organization address
address: COLLEGE ROAD contact info |
UK (BANGOR) | participant | 301˙296.00 |
| 6 |
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Organization address
address: CALLE SERRANO 117 contact info |
ES (MADRID) | participant | 296˙745.00 |
| 7 |
COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
Organization address
address: RUE LEBLANC 25 contact info |
FR (PARIS 15) | participant | 284˙505.00 |
| 8 |
DANMARKS TEKNISKE UNIVERSITET
Organization address
address: Anker Engelundsvej 1, Building 101A contact info |
DK (KONGENS LYNGBY) | participant | 274˙524.00 |
| 9 |
AECOM CZ SRO
Organization address
address: Trojska 92 contact info |
CZ (PRAGUE 7) | participant | 171˙155.00 |
| 10 |
CORPORACION CORPOGEN
Organization address
address: CARRERA 5 NO 66A-34 contact info |
CO (BOGOTA) | participant | 139˙086.00 |
| 11 |
UNIVERSITAET LEIPZIG
Organization address
address: RITTERSTRASSE 26 contact info |
DE (LEIPZIG) | participant | 89˙871.04 |
| 12 |
SYNDIAL SPA - ATTIVITA DIVERSIFICATE
Organization address
address: Piazza Boldrini 1 contact info |
IT (SAN DONATO MILANESE) | participant | 50˙005.00 |
| 13 |
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Organization address
address: FAHNENBERGPLATZ contact info |
DE (FREIBURG) | participant | 24˙890.96 |
| 14 |
THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO
Organization address
address: KINGS COLLEGE CIRCLE 27 contact info |
CA (TORONTO) | participant | 0.00 |
Mappa
Word cloud
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Obiettivo del progetto (Objective)
'MAGICPAH aims to explore, understand and exploit the catalytic activities of microbial communities involved in the degradation of persistent PAHs. It will integrate (meta-) genomic studies with in-situ activity assessment based on stable isotope probing particularly in complex matrices of different terrestrial and marine environments. PAH degradation under various conditions of bioavailability will be assessed as to improve rational exploitation of the catalytic properties of bacteria for the treatment and prevention of PAH pollution. We will generate a knowledge base not only on the microbial catabolome for biodegradation of PAHs in various impacted environmental settings based on genome gazing, retrieval and characterization of specific enzymes but also on systems related bioavailability of contaminant mixtures. MAGICPAH takes into account the tremendous undiscovered metagenomic resources by the direct retrieval from genome/metagenome libraries and consequent characterization of enzymes through activity screens. These screens will include a high-end functional small-molecule fluorescence screening platform and will allow us to directly access novel metabolic reactions followed by their rational exploitation for biocatalysis and the re-construction of biodegradation networks. Results from (meta-) genomic approaches will be correlated with microbial in situ activity assessments, specifically dedicated to identifying key players and key reactions involved in anaerobic PAH metabolism. Key processes for PAH metabolism particularly in marine and composting environments and the kinetics of aerobic degradation of PAH under different conditions of bioavailability will be assessed in model systems, the rational manipulation of which will allow us to deduce correlations between system performance and genomic blueprint. The results will be used to improve treatments of PAH-contaminated sites.'
Introduzione (Teaser)
Researchers are mining polluted natural environments for bacteria that can naturally metabolise polyaromatic hydrocarbons (PAHs), a common and toxic pollutant.