ITCSCEN
Binuclear Non-Coupled Copper Enzymes in Neurobiology: An Integrated Computational/Spectroscopic Investigation
| Coordinatore | UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE.
Organization address
address: "Ellison Place, Ellison Building" contact info |
| Nazionalità Coordinatore | United Kingdom [UK] |
| Totale costo | 258˙386 € |
| EC contributo | 258˙386 € |
| Programma | FP7-PEOPLE
Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) |
| Code Call | FP7-PEOPLE-2010-IOF |
| Funding Scheme | MC-IOF |
| Anno di inizio | 2011 |
| Periodo (anno-mese-giorno) | 2011-05-16 - 2014-07-31 |
Partecipanti
| # | ||||
|---|---|---|---|---|
| 1 |
UNIVERSITY OF NORTHUMBRIA AT NEWCASTLE.
Organization address
address: "Ellison Place, Ellison Building" contact info |
UK (NEWCASTLE UPON TYNE) | coordinator | 258˙386.80 |
Mappa
Word cloud
Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.
Obiettivo del progetto (Objective)
'Every third protein contains metal as cofactor. Cu-enzymes plays crucial rules in key processes in bioenergetics, mitochondrial respiration, neurotransmitter biosynthesis, antioxidation and pigmentation Therefore they are intensive targets for discovering new drugs and the understanding of their structure-functions relationships will provide new insight in translational and biomedical research. In this Marie Curie International Outgoing Fellowship I will investigate the mechanism of important two bi nuclear cupper enzyme – Peptidylglycine α-Amidating Monooxygenase (PAM) and Dopamine β-Monooxygense (DBM) which catalyze hydroxylation of substrates in crucial importance for neurobiology . The miss functionalities of these enzymes are related with nervous system disorders therefore revealing it mechanism will provide advanced opportunities for design of new drugs. In order to achieve this knowledge we will apply integrated combination of the most advanced spectroscopic techniques and state of the art computational methods.'
Introduzione (Teaser)
Scientists have shed light on the mechanisms of function of two important copper (Cu)-containing enzymes involved in nervous system disorders. Increased understanding should lead to advances in drug design, protein engineering and biotechnology.