TBVAC2020 project deliverables
The page lists 35 deliverables related to the research project "TBVAC2020".
List of Deliverables
| title and desprition | type | last update |
|---|---|---|
Data from measurements of selected immune mediatorsData from measurements of selected immune mediators (including epigenetic modifiers of immune responses and associated infant cellular responses) in UK and Ugandan infants as well as the effect of BCG vaccination on these mediators (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Evaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 TcellsEvaluation of ex-vivo frequencies, phenotype and functional properties of M.tb-specific CD4- and CD8 Tcells, macrophage subsets and plasma chemokines and cytokines in patients with M.tb or M.tb/HIV co-infection, before, during and after treatment (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Combination of HBHA and adjuvant has been selectedpublication on HBHA adjuvant selection Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Correlate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and humanCorrelate the quantity and quality of lipid-specific immune responses in CD1b-transgenic mice, guinea pigs and humans immunized with live- and lipid-based vaccines with the outcome of vaccination (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Validate biomarkers that predict the development of active TB in HIV infected personsValidate biomarkers that predict the development of active TB in HIV infected persons will be validated in a second set of plasma (M42) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
List of the autophagic and miRNA markers analyzed and correlatioList of the autophagic and miRNA markers analyzed and correlation with TB clinical outcome (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Transcriptome analyses of approx. 700 microarrays of Belarus cohortTranscriptome analyses of approx. 700 microarrays of Belarus cohort completed; dData analysis and validation with qPCR completed. First cell specific biosignatures identified in Belarus Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
RNA expression correlate of functionalRNA expression correlate of functional (whole blood killing) immune responses to M.tb infection, BCG or novel TB vaccines (M36) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Identification of potential immune correlates from the human mycobacterial challenge modelreport on Identification of potential immune correlates from the human mycobacterial challenge model Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Identification of a signature that distinguishes long term non- progressors from recently infected individualsIdentification of a signature that distinguishes long term non- progressors from recently infected individuals, and validation in second cohort(M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Correlates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participantsCorrelates of risk for, and protection from, active TB based on host markers obtained by 4 different analytical platforms on the same participants (M.tb antigen specific marker production in whole blood, RNA sequencing, metabolomics and miRNA expression) (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Transcriptomic, immunomic and metabolic correlates of TB infectionTranscriptomic, immunomic and metabolic correlates of TB infection, vaccine induced immunity and protection (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Evaluation of the association between the lymphocyte granule release and cytotoxic molecules, and the clinical status of Mtb infectionâ€(M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIAData on head-to-head assay comparisons and finalised SOPs for whole blood and PBMC ICS, and MGIA for the measurement of correlates of protection against TB (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Identification of a repertoire of surface molecules on NK cells and DC subsets and related cytokines associated with latent versus active TBIdentification of a repertoire of surface molecules on NK cells and DC subsets and of related cytokines associated with latency versus active TB (M36) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Bioinformatic signature validation and data integrationBioinformatic signature validation and data integration. Pathway analysis of long term non-progressor Signatures (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Frequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profilesFrequencies of vaccine-induced antigen-specific CD4 and CD8 T cells and their transcriptomic profiles (cytokine, chemokine and cytotoxic molecule expression, memory, activation and homing markers, chemokine receptors, etc) in M.tbuninfected, M.tb-infected (latent), TB diseased and in vaccinated persons (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
3 Annual project meetingsAnnual project meetings (TBVI; M14, M26, M38) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
A first version TB Biomarker data baseA first version TB Biomarker data base for tailor made selection of assays for specific trials and studies (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Targeted Luminex analysis to define M.tb-specific soluble host bio-signaturesTargeted Luminex analysis to define M.tb-specific soluble host bio-signatures from subjects with different TB/HIV infection phenotypes that can be used for identification of ‘at-risk’ subjects. Samples from minimally 3- sites (Gambia, S. Africa, Malawi) (M36) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Collection of samples from S. Korean LTBI cohortCollection of samples (plasma/serum, QFT supernatants/blood clots, WBA supernatants, RNA and mRNA PAXgene tubes) from S. Korean LTBI cohort. (M24) and Testing of biomarkers using standardized assay protocols on samples from S. Korean LTBI cohort (M42) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Detection of cytotoxic and bactericidal molecules intracellularly aDetection of cytotoxic and bactericidal molecules intracellularly and in stimulated plasma by ELISA/Luminex in patients before and during therapy (M48) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Establish Portfolio management committeeEstablish PMC and processes and implementation of portfolio management approach (M8) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Cohort data base and related specimen bank collectionCohort data base and related specimen bank collection. Four hundred HIV-infected and uninfected subjects either with LTBI, active TB followed during treatment and controls no M.tb-infected will be enrolled (M30) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Discovery Luminex analysis define key antigen-analyte and dcRT-MLPA RNA analysis combinationsDiscovery Luminex analysis using Gambian and S. African subjects to define key antigen-analyte and dcRT-MLPA RNA analysis combinations (M18) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Global TB vaccine meetingOrganization of global vaccine meeting (M10) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Project website establishedProject website established Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Websites, patent fillings, videos etc. | 2020-02-26 |
Correlates of risk for, and protection from, active TBCorrelates of risk for, and protection from, active TB based on host markers produced in response to M.tb infection stage specific proteins (M40) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trialReport with data of Evaluation of transcriptomic and other immune correlates identified in MVA85A infant efficacy trial in samples from subsequent clinical trials with optimised immunisation regimes Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Identification of transcriptomic biomarkers predictive of an efficient immune responseIdentification of transcriptomic biomarkers predictive of an efficient immune response to MTBVAC vs. BCG (M24) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Fully optimized protocols for isolation and ICS characterization of Suction BlisterFully optimized protocols for isolation and ICS characterization of Suction Blister Mononuclear Cells and SBMC based MGIA (M2412) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Evaluate M.tb- and lipid-specific gene- and protein expression in a sample bankEvaluate M.tb- and lipid-specific gene- and protein expression in a sample bank containing mRNA and supernatants from bronchoalveolar lavage cells and blood from the German study cohort “TB-or-not-TBâ€. (M36) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Obtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ARTObtain the transcriptomic signature of whole blood from HIV infected patients longitudinally on ART; and identify potential biomarkers of reduced susceptibility to TB, incl. diagnostic and prognostic protein biomarkers in plasma (M30) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
Systems biology analysis to define biosignatures of protection to latent TBSystems biology analysis to define biosignatures of protection to latent TB using TB exposed but persistently TST negative subjects (combined metabolomics, RNA-seq) (M36) Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |
correlation of hematopoietic progenitor cell populationsReport on correlation of hematopoietic progenitor cell populations with vaccine immunogenicity and risk Programme: H2020-EU.3.1.2. - Topic(s): PHC-08-2014 |
Documents, reports | 2020-02-26 |