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N-SHEAD

Nanoarrays: Self-assembled Hotspots for Enhanced Analyte Detection

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

N-SHEAD project word cloud

Explore the words cloud of the N-SHEAD project. It provides you a very rough idea of what is the project "N-SHEAD" about.

saliva limits signal extreme enhancements blood nanoparticle plasmonic inaccuracy surface limitations technique sharp treatment additionally sensing liquid enormous shaped mixtures implications colorectal speed precise enhanced biological biosensing disease raman stars rapid positioning amounts metallic innovations diagnosis people stage throughput detected tips multiple demonstrated utilise limit million detect electrotuneable overcoming nanoparticles ultrasensitive severe scattering samples extended urine separation cancer sensitivity trace ellipsoids advantage virus sers me generation diseases versatility maximise biomarker biosensors sensors electrochemically global transform prevalent insensitivity specificity single self manner world analyte push assembly molecule interface detection

Project "N-SHEAD" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.imperial.ac.uk/edel-group/
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-04-08 to 2017-04-07

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

I aim to transform the way disease is currently detected through innovations in the design of nanoparticle-based biosensors that can be used to detect a number of diseases with global implications. The three most significant challenges facing biosensing are inaccuracy, insensitivity, and low-throughput detection. One technique that is capable of facing these challenges is Surface Enhanced Raman Scattering (SERS) which has demonstrated potential for extreme sensitivity (single molecule detection) and rapid, multiple-analyte detection within complex mixtures. Early stage diagnosis of disease requires the detection of trace amounts of analyte in multi-component biological samples (blood, urine, saliva). It is therefore particularly important for sensors to reach the single-molecule detection limit. Further, the ability to analyse biological samples without separation or other treatment steps is a crucial advantage of SERS. My approach involves the electrotuneable self-assembly of plasmonic nanoparticles at a liquid-liquid interface for SERS detection, overcoming the severe limitations of current sensors (sensitivity, specificity and speed). I will electrochemically control the positioning of the nanoparticles in a precise manner to maximise the Raman signal. Additionally I will utilise shaped nanoparticles, such as stars and ellipsoids, exploiting the enormous Raman enhancements observed at sharp metallic tips to push the sensitivity towards single-molecule detection limits. The ultrasensitive sensing capabilities will be extended to colorectal cancer diagnosis the third most prevalent cancer in the world which effects 1.4 million people per year. Due to the versatility of this system it can be adapted to any disease or virus where the related biomarker is known. This approach will allow me to build a new generation of sensors that will transform single-molecule SERS detection

Publications

List of publications.
year	authors and title	journal	last update
2016	Leonora Velleman, Debabrata Sikdar, Vladimir A. Turek, Anthony R. Kucernak, Steve J. Roser, Alexei A. Kornyshev, Joshua B. Edel Tuneable 2D self-assembly of plasmonic nanoparticles at liquid\|liquid interfaces published pages: 19229-19241, ISSN: 2040-3364, DOI: 10.1039/C6NR05081F	Nanoscale 8/46	2019-07-24

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