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EPICONNECT SIGNED

Functional brain networks in epilepsy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EPICONNECT project word cloud

Explore the words cloud of the EPICONNECT project. It provides you a very rough idea of what is the project "EPICONNECT" about.

electric simultaneously resolution deep tool electrodes connectivity added treatment stage fmri sklodowska density structures placed combined scalp mm geneva recorded pieter few quantify spatial temporal recordings oxygen mierlo dr epilepsy mapping epileptic images sensitive magnetic networks ghent combining patients influence brain eeg ms university meant laboratory algorithms fellowship hd electroencephalography algorithm imaging final accurate explore voltage localize communication measuring ugent resonance concentration first difference ameliorate region fbm plusmn record 256 labs world regions invasive training van prospective causes seizures marie global 32 lab curie functional laboratories

Project "EPICONNECT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Project website	https://www.ugent.be/en/research/research-ugent/trackrecord/trackrecord-h2020/msca-h2020/msca-if-epiconnect.htm
Total cost	211˙964 €
EC max contribution	211˙964 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-GF
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2018-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT GENT UNIVERSITEIT GENT Organization address address: SINT PIETERSNIEUWSTRAAT 25 city: GENT postcode: 9000 website: http://www.ugent.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (GENT)	coordinator	211˙964.00
2	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	partner	0.00

Map

Project objective

This proposal for a Marie Sklodowska-Curie Global Fellowship is meant for the training of Dr. Pieter van Mierlo, currently at Ghent University, in the Functional Brain Mapping Laboratory (FBM Lab) of the University of Geneva, one of the world leading brain imaging laboratories. The goal of the project is to explore the communication between brain regions in epilepsy patients to ameliorate their treatment. In the first stage a non-invasive tool, ElectroEncephaloGraphy (EEG), will be used to measure the electric field of the brain through electrodes placed on top of the scalp. By measuring the voltage difference between the EEG electrodes the electric field of the brain can be studied with a high temporal resolution (ms). Recently, high density EEG (hd-EEG) systems have been developed with up to 256 electrodes. These systems allow more accurate measurements compared to the old systems having only ± 32 electrodes. The FBM Lab is one of the few labs that have hd-EEG recordings of epilepsy patients. In this project we will develop an algorithm to investigate the brain networks in epilepsy patients based on hd-EEG recordings. The brain networks will be studied to localize the epileptic focus, the brain region that causes the seizures. In the second stage hd-EEG will be combined with functional Magnetic Resonance Imaging (fMRI) that images the concentration of oxygen in the brain with a high spatial resolution (mm). The simultaneously recorded hd-EEG / fMRI allows studying the brain networks with both a high temporal and spatial resolution. Furthermore, fMRI is more sensitive to record brain activity of deep brain structures compared to hd-EEG. The added value of combining hd-EEG with fMRI to localize the epileptic focus will be assessed. In the third and final stage, the developed algorithms will be implemented at the UGent. A prospective study will be done to quantify the influence of functional connectivity analysis on patients’ treatment management.

Publications

List of publications.
year	authors and title	journal	last update
2018	Thibault Verhoeven, Ana Coito, Gijs Plomp, Aljoscha Thomschewski, Francesca Pittau, Eugen Trinka, Roland Wiest, Karl Schaller, Christoph Michel, Margitta Seeck, Joni Dambre, Serge Vulliemoz, Pieter van Mierlo Automated diagnosis of temporal lobe epilepsy in the absence of interictal spikes published pages: 10-15, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2017.09.021	NeuroImage: Clinical 17	2020-02-24
2017	Pieter van Mierlo, Gregor Strobbe, Vincent Keereman, GwÃ©nael Birot, Stefanie Gadeyne, Markus Gschwind, Evelien Carrette, Alfred Meurs, Dirk Van Roost, Kristl Vonck, Margitta Seeck, Serge VulliÃ©moz, Paul Boon Automated long-term EEG analysis to localize the epileptogenic zone published pages: 322-333, ISSN: 2470-9239, DOI: 10.1002/epi4.12066	Epilepsia Open 2/3	2020-02-24
2018	Pieter van Mierlo, Octavian Lie, Willeke Staljanssens, Ana Coito, Serge VulliÃ©moz Influence of Time-Series Normalization, Number of Nodes, Connectivity and Graph Measure Selection on Seizure-Onset Zone Localization from Intracranial EEG published pages: , ISSN: 0896-0267, DOI: 10.1007/s10548-018-0646-7	Brain Topography	2020-02-24
2017	Octavian V. Lie, Pieter van Mierlo Seizure-Onset Mapping Based on Time-Variant Multivariate Functional Connectivity Analysis of High-Dimensional Intracranial EEG: A Kalman Filter Approach published pages: 46-59, ISSN: 0896-0267, DOI: 10.1007/s10548-016-0527-x	Brain Topography 30/1	2020-02-24
2017	Willeke Staljanssens, Gregor Strobbe, Roel Van Holen, GwÃ©naÃ«l Birot, Markus Gschwind, Margitta Seeck, Stefaan Vandenberghe, Serge VulliÃ©moz, Pieter van Mierlo Seizure Onset Zone Localization from Ictal High-Density EEG in Refractory Focal Epilepsy published pages: 257-271, ISSN: 0896-0267, DOI: 10.1007/s10548-016-0537-8	Brain Topography 30/2	2020-02-24
2016	Markus Gschwind, Pieter van Mierlo Difficulty of Comparing the Multiple Heterogeneous Approaches: Comment to Transcranial Direct Current Stimulation in Epilepsy published pages: 459-461, ISSN: 1935-861X, DOI: 10.1016/j.brs.2016.03.003	Brain Stimulation 9/3	2020-02-24
2016	Ana Coito, Christoph M. Michel, Pieter van Mierlo, Serge Vulliemoz, Gijs Plomp Directed Functional Brain Connectivity Based on EEG Source Imaging: Methodology and Application to Temporal Lobe Epilepsy published pages: 2619-2628, ISSN: 0018-9294, DOI: 10.1109/TBME.2016.2619665	IEEE Transactions on Biomedical Engineering 63/12	2020-02-24
2017	Willeke Staljanssens, Gregor Strobbe, Roel Van Holen, Vincent Keereman, Stefanie Gadeyne, Evelien Carrette, Alfred Meurs, Francesca Pittau, Shahan Momjian, Margitta Seeck, Paul Boon, Stefaan Vandenberghe, Serge Vulliemoz, Kristl Vonck, Pieter van Mierlo EEG source connectivity to localize the seizure onset zone in patients with drug resistant epilepsy published pages: 689-698, ISSN: 2213-1582, DOI: 10.1016/j.nicl.2017.09.011	NeuroImage: Clinical 16	2020-02-24

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The information about "EPICONNECT" are provided by the European Opendata Portal: CORDIS opendata.