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BREAKBEN SIGNED

Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

BREAKBEN project word cloud

Explore the words cloud of the BREAKBEN project. It provides you a very rough idea of what is the project "BREAKBEN" about.

advantages head mri neuroimaging resolution conductivity chance verification structure barrier techniques combinations jump near believe nonuniqueness utilizing presented brain dynamics breakben definition magnetoencephalography accurate nervous suitable qualitative magnetic resonance inform currents ultra ulf individual priori imaging clinical cdi reliability unprecedented validation meg wealth human function revolution cerebral density multimodal injected nci image simultaneous breakthroughs revolutionize neural neuronal combining workflows accurately completely breaking magnetism edge

Project "BREAKBEN" data sheet

The following table provides information about the project.

Coordinator	AALTO KORKEAKOULUSAATIO SR Organization address address: OTAKAARI 1 city: ESPOO postcode: 2150 website: http://www.aalto.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Finland [FI]
Project website	http://breakben.eu/
Total cost	3˙998˙793 €
EC max contribution	3˙998˙793 € (100%)
Programme	1. H2020-EU.1.2.1. (FET Open)
Code Call	H2020-FETOPEN-2014-2015-RIA
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	AALTO KORKEAKOULUSAATIO SR AALTO KORKEAKOULUSAATIO SR Organization address address: OTAKAARI 1 city: ESPOO postcode: 2150 website: http://www.aalto.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	coordinator	959˙030.00
2	PHYSIKALISCH-TECHNISCHE BUNDESANSTALT PHYSIKALISCH-TECHNISCHE BUNDESANSTALT Organization address address: Bundesallee 100 city: BRAUNSCHWEIG postcode: 38116 website: www.ptb.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BRAUNSCHWEIG)	participant	779˙268.00
3	Teknologian tutkimuskeskus VTT Oy Teknologian tutkimuskeskus VTT Oy Organization address address: VUORIMIEHENTIE 3 city: Espoo postcode: 2150 website: www.vtt.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (Espoo)	participant	776˙141.00
4	TECHNISCHE UNIVERSITAET ILMENAU TECHNISCHE UNIVERSITAET ILMENAU Organization address address: EHRENBERGSTRASSE 29 city: ILMENAU postcode: 98693 website: www.tu-ilmenau.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ILMENAU)	participant	442˙871.00
5	UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA UNIVERSITA DEGLI STUDI GABRIELE D'ANNUNZIO DI CHIETI-PESCARA Organization address address: Via dei Vestini 31 city: CHIETI postcode: 66013 website: www.unich.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (CHIETI)	participant	440˙100.00
6	MEGIN OY MEGIN OY Organization address address: SILTASAARENKATU 18-20 A city: HELSINKI postcode: 530 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	413˙735.00
7	HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ Organization address address: STENBACKINKATU 9 city: HELSINKI postcode: 29 website: www.hus.fi contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (HELSINKI)	participant	187˙646.00

Map

Project objective

By combining accurate magnetic measurements of neural activity with near-simultaneous high-definition measurements of cerebral structure – provided by novel methods in ultra-low-field magnetic resonance imaging (ULF MRI ) – we will be able to image the dynamics of human brain function at unprecedented resolution and reliability. BREAKBEN will achieve a revolution in neuroimaging; we aim at breaking the barrier for measurement of neuronal currents by ULF MRI (neural current imaging; NCI) as well as breaking the nonuniqueness barrier for magnetoencephalography (MEG) by combining it with ULF MRI and accurately presented a priori information. A key aspect in utilizing the a priori information is injected current density imaging (CDI), which will inform us about the individual conductivity structure of the head. Using novel verification and validation approaches, we will demonstrate the unique advantages of these multimodal techniques. These breakthroughs will result in completely different workflows in brain imaging, also suitable for clinical use. We believe that we are at the edge of a qualitative technology jump with ULF MRI, its applications and combinations. This will lead to a wealth of new applications and revolutionize the way we do magnetism-based measurements of the nervous system. Europe has the unique chance to lead this revolution.

Deliverables

List of deliverables.
Guidelines for safety and regulatory requirements	Documents, reports	2020-02-26 11:51:52
Data Management Plan	Open Research Data Pilot	2020-02-26 11:51:52
External web-site	Websites, patent fillings, videos etc.	2020-02-26 11:51:52
Analysis of the value of a priori information	Documents, reports	2020-02-07 15:38:08
MEG-MRI on healthy subjects	Demonstrators, pilots, prototypes	2020-02-07 15:38:12
Demonstration of CDI in vivo	Demonstrators, pilots, prototypes	2020-02-07 15:38:10
Connectivity maps from human subject data	Documents, reports	2020-02-07 15:38:11
Dissemination activities	Documents, reports	2020-02-07 15:38:06

Take a look to the deliverables list in detail: detailed list of BREAKBEN deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2017	Eva Al-Dabbagh, Peter HÃ¶mmen, Jan-Hendrik Storm, Nora HÃ¶fner, Rainer KÃ¶rber Ultra-sensitive SQUID system for pulsed field applications published pages: , ISSN: , DOI:	EUCAS 2017 Poster Session biennial	2020-02-26
2018	Laura Marzetti Understanding neural synchronization by combining good practice and novel methods in electrophysiological functional connectivity analysis published pages: , ISSN: , DOI:	19th IOP World Congress biennial	2020-02-26
2017	Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto Ilmoniemi, Gian Luca Romani, Vittorio Pizzella Effects of MEGâ€“MRI coregistration error on functional connectivity estimates published pages: , ISSN: , DOI:	OHBM 2017 poster session annual	2020-02-26
2017	Mikko Luukinen Suprajohtavan kvantti-interferenssilaitteen automatisoitu virittÃ¤minen aivokuvantamista varten [Automated tuning of a superconducting quantum interference device for brain imaging] published pages: , ISSN: , DOI:		2020-02-26
2018	Sebastian Neuber Konstruktion eines Gestells mit stufenlosem Manipulator der z-Achse fÃ¼r unterschiedliche Kryostaten innerhalb eines bestehenden Messsystems zur Probanden- und Probenmessung in magnetisch geschirmten RÃ¤umen published pages: , ISSN: , DOI:		2020-02-26
2017	Iiro Lehto Superconducting prepolarization coil for ultra-low-field MRI published pages: , ISSN: , DOI:		2020-02-26
2017	Jens Haueisen, Alexander Hunold Concept of a physical head phantom MEG-MRI and NCI/CDI published pages: , ISSN: , DOI:	\"#brainTC\" annual	2020-02-26
2017	Alexander Hunold, Jens Haueisen Simulated current density magnitudes and orientations for transcranial direct current stimulation montages used in depression studies published pages: , ISSN: , DOI:	BaCI biennial	2020-02-26
2018	Alexander Hunold, Daniel Strohmeier, Patrique Fiedler, Jens Haueisen Head phantoms for electroencephalography and transcranial electric stimulation: a skull material study published pages: 683-689, ISSN: 0013-5585, DOI: 10.1515/bmt-2017-0069	Biomedical Engineering / Biomedizinische Technik 63/6	2020-02-26
2019	Gavriela Vranou Assessing the value of a priori information in solving the MEG inverse problem published pages: , ISSN: , DOI:		2020-02-26
2019	Antti J. Makinen, Koos C. J. Zevenhoven, Risto J. Ilmoniemi Automatic Spatial Calibration of Ultra-Low-Field MRI for High-Accuracy Hybrid MEGâ€“MRI published pages: 1317-1327, ISSN: 0278-0062, DOI: 10.1109/tmi.2019.2905934	IEEE Transactions on Medical Imaging 38/6	2020-02-26
2018	Roberto Guidotti, Raffaele Sinibaldi, Cinzia De Luca, Allegra Conti, Risto J. Ilmoniemi, Koos C. J. Zevenhoven, Per E. Magnelind, Vittorio Pizzella, Cosimo Del Gratta, Gian Luca Romani, Stefania Della Penna Optimized 3D co-registration of ultra-low-field and high-field magnetic resonance images published pages: e0193890, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0193890	PLOS ONE 13/3	2020-02-26
2018	Alexander Hunold, Anton Kresinsky, Berd A. Sabel, Jens Haueisen Simulation of the current density in the retina for transorbital electric current stimulation published pages: , ISSN: , DOI:	\"Workshop \"\"Innovative Verarbeitung bioelektrischer und biomagnetischer Signale\"\"\" biennial	2020-02-26
2017	Leif GrÃ¶nberg, Mikko Kiviranta, Visa Vesterinen, Janne Lehtinen, Slawomir Simbierowicz, Juho Luomahaara, Mika Prunnila, Juha Hassel Side-wall spacer passivated sub- Î¼ m Josephson junction fabrication process published pages: 125016, ISSN: 0953-2048, DOI: 10.1088/1361-6668/aa9411	Superconductor Science and Technology 30/12	2020-02-26
2018	Koos C. J. Zevenhoven, MÃ¤kinen, Antti J., and Risto J. Ilmoniemi. Superconducting receiver arrays for magnetic resonance imaging published pages: , ISSN: , DOI:		2020-02-26
2018	Christoph Dinh, Lorenz Esch, Johannes RÃ¼hle, Steffen Bollmann, Daniel GÃ¼llmar, Daniel Baumgarten, Matti S. HÃ¤mÃ¤lÃ¤inen, Jens Haueisen Real-Time Clustered Multiple Signal Classification (RTC-MUSIC) published pages: 125-128, ISSN: 0896-0267, DOI: 10.1007/s10548-017-0586-7	Brain Topography 31/1	2020-02-26
2018	Alexander Hunold, Uwe Graichen, Klaus Schellhorn, Jens Haueisen Flexible Stimulationshaube fÃ¼r TES Anwendungen: Technische Parameter und Stromdichtesimulationen published pages: , ISSN: , DOI:	62. Jahrestagung der DGKN 2018 mit Richard-Jung-Kolleg annual	2020-02-26
2017	Eva Al-Dabbagh Hoch-sensitives SQUID-Messsystem fÃ¼r Anwendungen mit gepultsten Feldern published pages: , ISSN: , DOI:		2020-02-26
2018	Alexander Hunold, Uwe Graichen, Klaus Schellhorn, Jens Haueisen AlexandSimulated current density and technical parameters of TES applied with a flexible cap published pages: , ISSN: , DOI:	52. Annual Conference of the German Society for Biomedical Engineering (DGBMT within VDE) annual	2020-02-26
2017	RenÃ© Machts, Alexander Hunold, Jens Haueisen Realization and Testing of a 3D Electrode Array for measuring Electric Potential Differences in a Volume Conductor published pages: , ISSN: , DOI:	51. Jahrestagung der Biomedizinischen Technik und DreilÃ¤ndertagung der Medizinischen Physik (BMTMedPhys) annual	2020-02-26
2018	Juho Luomahaara, Mikko Kiviranta, Leif Gronberg, Koos C. J. Zevenhoven, Petteri Laine Unshielded SQUID Sensors for Ultra-Low-Field Magnetic Resonance Imaging published pages: 1-4, ISSN: 1051-8223, DOI: 10.1109/tasc.2018.2791022	IEEE Transactions on Applied Superconductivity 28/4	2020-02-26
2016	Aino Tervo Noise optimization of multi-layer insulation in liquid-helium cryostat for brain imaging published pages: , ISSN: , DOI:		2020-02-26
2018	Alexander Hunold, Klaus Schellhorn, Jens Haueisen Simulating the superposition of transcranial electric stimulations targeting the visual cortex published pages: , ISSN: , DOI:	BIOMAG2018 biennial	2020-02-26
2019	Antea D\'Andrea, Federico Chella, Tom R. Marshall, Vittorio Pizzella, Gian Luca Romani, Ole Jensen, Laura Marzetti Alpha and alpha-beta phase synchronization mediate the recruitment of the visuospatial attention network through the Superior Longitudinal Fasciculus published pages: 722-732, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.12.056	NeuroImage 188	2020-02-26
2018	Paolo Capotosto, Stefania della Penna, Vittorio Pizzella, Filippo Zappasodi, Gian Luca Romani, Risto J. Ilmoniemi, Alfredo Brancucci Theta-burst stimulation causally affects side perception in the Deutschâ€™s octave illusion published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-31248-1	Scientific Reports 8/1	2020-02-26
2019	Federico Chella, Laura Marzetti, Matti Stenroos, Lauri Parkkonen, Risto J. Ilmoniemi, Gian Luca Romani, Vittorio Pizzella The impact of improved MEGâ€“MRI co-registration on MEG connectivity analysis published pages: 354-367, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2019.04.061	NeuroImage 197	2020-02-26
2017	Sommariva, Sara; Sorrentino, Alberto; Piana, Michele; Pizzella, Vittorio; Marzetti, Laura A comparative study of the robustness of frequency--domain connectivity measures to finite data length published pages: , ISSN: 0896-0267, DOI:	Brain Topography 1	2020-02-26
2018	Alessio Basti, Vittorio Pizzella, Federico Chella, Gian Luca Romani, Guido Nolte, Laura Marzetti Disclosing large-scale directed functional connections in MEG with the multivariate phase slope index published pages: 161-175, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.03.004	NeuroImage 175	2020-02-26
2017	Federico Chella, Antea D\'Andrea, Alessio Basti, Vittorio Pizzella, Laura Marzetti Non-linear Analysis of Scalp EEG by Using Bispectra: The Effect of the Reference Choice published pages: , ISSN: 1662-453X, DOI: 10.3389/fnins.2017.00262	Frontiers in Neuroscience 11	2020-02-26
2018	J-H. Storm, A. M. CassarÃ , N. HÃ¶fner, P. HÃ¶mmen, E. Neufeld, R. KÃ¶rber and N. Kuster Computational and phantom-based evaluation of dc neuronal current imaging with ultra-low field magnetic resonance published pages: , ISSN: , DOI:	Biomag 2018 Poster Session biennial	2020-02-26
2019	P. HÃ¶mmen, J.-H. Storm, N. HÃ¶fner, R. KÃ¶rber Demonstration of full tensor current density imaging using ultra-low field MRI published pages: , ISSN: 0730-725X, DOI: 10.1016/j.mri.2019.03.010	Magnetic Resonance Imaging	2020-02-26
2018	N. HÃ¶fner, J.-H. Storm, P. HÃ¶mmen, R. KÃ¶rber Neuronal current imaging using 3D ultra-low field MRI - preliminary results published pages: , ISSN: , DOI:	Biomag 2018 Poster Session biennial	2020-02-26
2018	P. HÃ¶mmen, J-H. Storm, N. HÃ¶fner, A. Hunold, R. Machts, J. Haueisen and R. KÃ¶rber Current Density Imaging in the Head using Ultra-Low Field Magnetic Resonance - An Advanced Phantom Study published pages: , ISSN: , DOI:	Biomag 2018 Poster Session biennial	2020-02-26
2018	Eva Al-Dabbagh, Jan-Hendrik Storm, Rainer Korber Ultra-sensitive SQUID Systems for Pulsed Fieldsâ€”Degaussing Superconducting Pick-Up Coils published pages: 1-5, ISSN: 1051-8223, DOI: 10.1109/TASC.2018.2797544	IEEE Transactions on Applied Superconductivity 28/4	2020-02-26
2016	Rainer KÃ¶rber, Jan-Hendrik Storm, Dietmar Drung and Martin Burghoff A modular and field tolerant ultra-low-noise multichannel SQUID system for ULF MRI and high frequency MEG published pages: , ISSN: , DOI:	BIOMAG2016 Poster Session biennial	2020-02-26
2016	Risto Ilmoniemi, Jens Haueisen, Mikko Kiviranta, Rainer KÃ¶rber, Jyrki MÃ¤kelÃ¤, Jukka Nenonen, Gian Luca Romani, and Koos Zevenhoven Breaking the Nonuniqueness Barrier in Electromagnetic Neuroimaging: the BREAKBEN project published pages: 409, ISSN: , DOI:	BIOMAG2016 poster/abstract biennial	2020-02-26
2016	J-H Storm, D Drung, M Burghoff, R KÃ¶rber A modular, extendible and field-tolerant multichannel vector magnetometer based on current sensor SQUIDs published pages: 94001, ISSN: 0953-2048, DOI: 10.1088/0953-2048/29/9/094001	Superconductor Science and Technology 29/9	2020-02-26
2016	Guidotti R., Sinibaldi R., De Luca C., Conti A., Ilmoniemi R. J., Zevenhonen K. C. J., Magnelind P., Pizzella V., Romani G. L. and Della Penna S. Optimized pipeline for the 3D co-registration of Low- and High-Field MRI published pages: , ISSN: , DOI:	BIOMAG 2016 Poster session biannual	2020-02-26
2016	Nora HÃ¶fner and Rainer KÃ¶rber and Marting Burghoff Towards direct neuronal current imaging via ultra-low-field MR published pages: , ISSN: , DOI:	Proceedings of the workshop Biosignal Processing 2016	2020-02-26
2016	Koos C. J. Zevenhoven and Risto J. Ilmoniemi Recent advances in ultra-low-field MRI and its compatibility with other modalities published pages: 410, ISSN: , DOI:	BIOMAG2016 poster/abstract biennial	2020-02-26
2016	Corinna Horn, Alexander Hunold, Jens Haueisen, Michael Funke Comparison of dipole localization to interictal spikesin individual and standardized BEM upon three different age group published pages: , ISSN: , DOI:	BIOMAG2016 Poster Session biennial	2020-02-26
2016	Rainer KÃ¶rber, Jan-Hendrik Storm, Hugh Seton, Jyrki P MÃ¤kelÃ¤, Ritva Paetau, Lauri Parkkonen, Christoph Pfeiffer, Bushra Riaz, Justin F Schneiderman, Hui Dong, Seong-min Hwang, Lixing You, Ben Inglis, John Clarke, Michelle A Espy, Risto J Ilmoniemi, Per E Magnelind, Andrei N Matlashov, Jaakko O Nieminen, Petr L Volegov, Koos C J Zevenhoven, Nora HÃ¶fner, Martin Burghoff, Keiji Enpuku, S Y Yang, Jen-Jei Chieh, Jukka Knuutila, Petteri Laine, Jukka Nenonen SQUIDs in biomagnetism: a roadmap towards improved healthcare published pages: 113001, ISSN: 0953-2048, DOI: 10.1088/0953-2048/29/11/113001	Superconductor Science and Technology 29/11	2020-02-26
2016	Alexander Hunold, Stephan Lau, Yoshio Okada, Christos Papadelis, Jens Haueisen Calcified cortical tubers influence single dipole source localization published pages: , ISSN: , DOI:	BIOMAG2016 Poster Session biennial	2020-02-26
2017	Rainer KÃ¶rber Ultra-sensitive SQUID instrumentation for MEG and NCI by ULF MRI published pages: 795-798, ISSN: , DOI: 10.1007/978-981-10-5122-7_199	EMBEC & NBC 2017, IFMBE Proceedings 65	2020-02-26
2016	Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Guido Nolte, Laura Marzetti Bispectral pairwise interacting source analysis for identifying systems of cross-frequency interacting brain sources from electroencephalographic or magnetoencephalographic signals published pages: , ISSN: 2470-0045, DOI: 10.1103/PhysRevE.93.052420	Physical Review E 93/5	2020-02-26
2016	Aino E Tervo, Antti J MÃ¤kinen, Risto J Ilmoniemi, and Koos C J Zevenhoven Accurate mapping of magnetic fields generated by an ultra-low-field MRI device published pages: 407, ISSN: , DOI:	BIOMAG2016 poster/abstract biennial	2020-02-26
2016	Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Guido Nolte, Laura Marzetti Identifying pairwise interacting sources from the antisymmetric cross-bispectrum of EEG/MEG data published pages: , ISSN: , DOI:	OHBM 2016 Poster session annual	2020-02-26
2016	Yi-Cheng Hsu, Koos C.J. Zevenhoven, Ying-Hua Chu, Juhani Dabek, Risto J. Ilmoniemi, Fa-Hsuan Lin Rotary scanning acquisition in ultra-low-field MRI published pages: 2255-2264, ISSN: 0740-3194, DOI: 10.1002/mrm.25676	Magnetic Resonance in Medicine 75/6	2020-02-26
2016	Nora HÃ¶fner, Rainer KÃ¶rber, Jens Haueisen, Peter HÃ¶mmen and Martin Burghoff Neuronal current imaging (NCI) by Ultra-Low-Field MRI published pages: , ISSN: , DOI:	BIOMAG2016 Poster Session biennial	2020-02-26
2017	Jan-Hendrik Storm, Peter HÃ¶mmen, Diemtar Drung, Rainer KÃ¶rber An ultra-sensitive and wideband magnetometer based on a superconductingquantum interference devic published pages: 072603-1 - 07260, ISSN: 0003-6951, DOI: 10.1063/1.4976823	Applied Physics Letters weekly	2020-02-26
2016	Federico Chella, Vittorio Pizzella, Filippo Zappasodi, Laura Marzetti Impact of the reference choice on scalp EEG connectivity estimation published pages: 36016, ISSN: 1741-2560, DOI: 10.1088/1741-2560/13/3/036016	Journal of Neural Engineering 13/3	2020-02-26
2016	Antti J. MÃ¤kinen, Koos C. J. Zevenhoven, and Risto J. Ilmoniemi Eliminating co-registration in MEGâ€“MRI: automatic nonlinear calibration of ULF MRI published pages: 406, ISSN: , DOI:	Biomag2016 poster/abstract biennial	2020-02-26

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