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SVDs-at-target SIGNED

Small vessel diseases in a mechanistic perspective: Targets for Intervention Affected pathways and mechanistic exploitation for prevention of stroke and dementia

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SVDs-at-target project word cloud

Explore the words cloud of the SVDs-at-target project. It provides you a very rough idea of what is the project "SVDs-at-target" about.

link profound experimental health scientists clinicians individual molecular variability emerged underlying physiological damage clinical mri svds basic separated blood cohorts co ltbp1 validate strokes vessel compromise independent fact brings function least presentations mechanisms made dementia point brain cellular network 40 despite phenotyped tgf drive pressure human patient models animal expertly academic applicants interventions shared expertise diseases central matrix attractive intersect proteomics multiple 30 defects proof roles progress small ultra szlig revealed patients illuminated mechanistic encounter rank feasibility trials risk relevance vivo therapeutic proven treatments microvessels stroke exploratory timp3 efficacy genetic barrier isolated morbidities pressing technologies extracellular intervention cerebral

Project "SVDs-at-target" data sheet

The following table provides information about the project.

Coordinator	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.svds-at-target.eu/
Total cost	5˙998˙300 €
EC max contribution	5˙998˙300 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-PHC-2015-two-stage
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN Organization address address: GESCHWISTER SCHOLL PLATZ 1 city: MUENCHEN postcode: 80539 website: www.uni-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	975˙167.00
2	University of Vermont University of Vermont Organization address address: WATERMAN BUILDING 340 city: BURLINGTON postcode: 05405 0160 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (BURLINGTON)	participant	580˙375.00
3	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	576˙031.00
4	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	570˙875.00
5	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	555˙375.00
6	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	555˙375.00
7	WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER WESTFAELISCHE WILHELMS-UNIVERSITAET MUENSTER Organization address address: SCHLOSSPLATZ 2 city: MUENSTER postcode: 48149 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENSTER)	participant	555˙375.00
8	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	512˙369.00
9	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	450˙000.00
10	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	309˙506.00
11	ARTTIC ARTTIC Organization address address: RUE DU DESSOUS DES BERGES 58A city: PARIS postcode: 75013 website: www.arttic.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	290˙000.00
12	STROKE ALLIANCE FOR EUROPE STROKE ALLIANCE FOR EUROPE Organization address address: RUE WASHINGTON 40 city: BRUSSELS postcode: 1050 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUSSELS)	participant	45˙025.00
13	GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Organization address address: OSKAR VON MILLER RING 29 city: MUENCHEN postcode: 80333 website: www.gabo-mi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	22˙826.00

Map

Project objective

Stroke and dementia rank among the most pressing health issues in Europe. Cerebral small vessel diseases (SVDs) have emerged as a central link between these two major co-morbidities. SVDs account for more than 30% of strokes and at least 40% of dementia cases. They encounter multiple distinct diseases that can be separated based on their underlying genetic defects, risk factors, and clinical presentations. Despite this profound impact on human health, there are no treatments with proven efficacy against SVDs. The applicants have made major progress in identifying key mechanisms involved in SVDs and their co-morbidities. We recently identified blood pressure variability as a major independent risk factor for multiple SVDs, stroke, and dementia and illuminated the roles of the blood brain barrier and the extracellular matrix in small vessel function. We further identified novel molecular pathways (TIMP3, LTBP1, TGFß) that are shared between different SVDs and thus point towards common mechanisms. This EU network, which brings together basic scientists and academic clinicians, will make use of novel animal models and expertly phenotyped patient cohorts to identify key mechanisms common to multiple SVDs and determine how these mechanisms contribute to individual SVDs. We will: i) identify common molecular, cellular, and physiological mechanisms that compromise the function of microvessels in different SVDs; ii) determine how these common mechanistic defects intersect to drive brain damage; and iii) validate the relevance of mechanisms through interventions in experimental systems (isolated microvessels and in vivo) and in patients (exploratory proof of concept trials). Our resources including novel animal models and state-of-the art technologies (e.g. proteomics & ultra-high field MRI) as well as expertise in clinical trials support the feasibility of the approach. In fact, studies by the applicants already revealed novel attractive targets for therapeutic intervention.

Deliverables

List of deliverables.
Launch of website, Twitter and LinkedIn account	Websites, patent fillings, videos etc.	2020-01-28 10:06:08
Initial Dissemination plan	Websites, patent fillings, videos etc.	2020-01-28 10:06:08
Individualized press release for every partner	Websites, patent fillings, videos etc.	2020-01-28 10:06:08

Take a look to the deliverables list in detail: detailed list of SVDs-at-target deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Rainer Malik, Ganesh Chauhan, Matthew Traylor, Muralidharan Sargurupremraj, Yukinori Okada, Aniket Mishra, Loes Rutten-Jacobs, Anne-Katrin Giese, Sander W. van der Laan, Solveig Gretarsdottir, Christopher D. Anderson, Michael Chong, Hieab H. H. Adams, Tetsuro Ago, Peter Almgren, Philippe Amouyel, Hakan Ay, Traci M. Bartz, Oscar R. Benavente, Steve Bevan, Giorgio B. Boncoraglio, Robert D. Brown, Ad Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes published pages: 524-537, ISSN: 1061-4036, DOI: 10.1038/s41588-018-0058-3	Nature Genetics 50/4	2020-01-28
2017	Joanna M. Wardlaw, Francesca M. Chappell, Maria del Carmen ValdÃ©s HernÃ¡ndez, Stephen D.J. Makin, Julie Staals, Kirsten Shuler, Michael J. Thrippleton, Paul A. Armitage, Susana MuÃ±oz-Maniega, Anna K. Heye, Eleni Sakka, Martin S. Dennis White matter hyperintensity reduction and outcomes after minor stroke published pages: 10.1212/WNL.0000, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000004328	Neurology	2020-01-28
2017	Anne Joutel, Hugues Chabriat Pathogenesis of white matter changes in cerebral small vessel diseases: beyond vessel-intrinsic mechanisms published pages: 635-651, ISSN: 0143-5221, DOI: 10.1042/CS20160380	Clinical Science 131/8	2020-01-28
2016	Eric Jouvent, Edouard Duchesnay, Foued Hadj-Selem, FranÃ§ois De Guio, Jean-FranÃ§ois Mangin, Dominique HervÃ©, Marco Duering, Stefan Ropele, Reinhold Schmidt, Martin Dichgans, Hugues Chabriat Prediction of 3-year clinical course in CADASIL published pages: 1787-1795, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003252	Neurology 87/17	2020-01-28
2017	C. Eleana Zhang, Sau May Wong, Renske Uiterwijk, Julie Staals, Walter H. Backes, Erik I. Hoff, Tobien Schreuder, CÃ©cile R.L.P.N. Jeukens, Jacobus F.A. Jansen, Robert J. van Oostenbrugge Intravoxel Incoherent Motion Imaging in Small Vessel Disease published pages: 658-663, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.015084	Stroke 48/3	2020-01-28
2017	Thomas A Longden, Fabrice Dabertrand, Masayo Koide, Albert L Gonzales, Nathan R Tykocki, Joseph E Brayden, David Hill-Eubanks, Mark T Nelson Capillary K+-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow published pages: 717-726, ISSN: 1097-6256, DOI: 10.1038/nn.4533	Nature Neuroscience 20/5	2020-01-28
2016	Renske Uiterwijk, Robert J. van Oostenbrugge, Marjolein Huijts, Peter W. De Leeuw, Abraham A. Kroon, Julie Staals Total Cerebral Small Vessel Disease MRI Score Is Associated with Cognitive Decline in Executive Function in Patients with Hypertension published pages: , ISSN: 1663-4365, DOI: 10.3389/fnagi.2016.00301	Frontiers in Aging Neuroscience 8	2020-01-28
2016	Gro Klitgaard Povlsen, Thomas A Longden, Adrian D Bonev, David C Hill-Eubanks, Mark T Nelson Uncoupling of neurovascular communication after transient global cerebral ischemia is caused by impaired parenchymal smooth muscle K ir channel function published pages: 1195-1201, ISSN: 0271-678X, DOI: 10.1177/0271678X16638350	Journal of Cerebral Blood Flow & Metabolism 36/7	2020-01-28
2017	Rashid Ghaznawi, Jeroen de Bresser, Yolanda van der Graaf, Maarten HT Zwartbol, Theo D Witkamp, Mirjam I Geerlings, Jeroen Hendrikse Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study published pages: 0271678X1770597, ISSN: 0271-678X, DOI: 10.1177/0271678X17705974	Journal of Cerebral Blood Flow & Metabolism	2020-01-28
2016	K. Khavandi, R. L. Baylie, S. A. Sugden, M. Ahmed, V. Csato, P. Eaton, D. C. Hill-Eubanks, A. D. Bonev, M. T. Nelson, A. S. Greenstein Pressure-induced oxidative activation of PKG enables vasoregulation by Ca2+ sparks and BK channels published pages: ra100-ra100, ISSN: 1937-9145, DOI: 10.1126/scisignal.aaf6625	Science Signaling 9/449	2020-01-28
2017	The Lancet Neurology Vascular disease and neurodegeneration: advancing together published pages: 333, ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30086-8	The Lancet Neurology 16/5	2020-01-28
2017	Virginia E Hawkins, Ana C Takakura, Ashley Trinh, Milene R Malheiros-Lima, Colin M Cleary, Ian C Wenker, Todd Dubreuil, Elliot M Rodriguez, Mark T Nelson, Thiago S Moreira, Daniel K Mulkey Purinergic regulation of vascular tone in the retrotrapezoid nucleus is specialized to support the drive to breathe published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.25232	eLife 6	2020-01-28
2016	Martin Dichgans, Joanna Wardlaw, Eric Smith, Vera Zietemann, Sudha Seshadri, Perminder Sachdev, Geert Jan Biessels, Franz Fazekas, Oscar Benavente, Leonardo Pantoni, Frank-Erik De Leeuw, Bo Norrving, Paul Matthews, Christopher Chen, Vincent Mok, Marco DÃ¼ring, Will Whiteley, Kirsten Shuler, Alvaro Alonso, Sandra E. Black, Carol Brayne, Hugues Chabriat, Charlotte Cordonnier, Fergus Doubal, Emrah Du METACOHORTS for the study of vascular disease and its contribution to cognitive decline and neurodegeneration: An initiative of the Joint Programme for Neurodegenerative Disease Research published pages: 1235-1249, ISSN: 1552-5260, DOI: 10.1016/j.jalz.2016.06.004	Alzheimer\'s & Dementia 12/12	2020-01-28
2017	Martin Dichgans, Didier Leys Vascular Cognitive Impairment published pages: 573-591, ISSN: 0009-7330, DOI: 10.1161/CIRCRESAHA.116.308426	Circulation Research 120/3	2020-01-28
2017	Matthew Traylor, Rainer Malik, Mike A. Nalls, Ioana Cotlarciuc, Farid Radmanesh, Gudmar Thorleifsson, Ken B. Hanscombe, Carl Langefeld, Danish Saleheen, Natalia S. Rost, Idil Yet, Tim D. Spector, Jordana T. Bell, Eilis Hannon, Jonathan Mill, Ganesh Chauhan, Stephanie Debette, Joshua C. Bis, W.T. Longstreth, M. Arfan Ikram, Lenore J. Launer, Sudha Seshadri, Monica Anne Hamilton-Bruce, Jordi Jimenez Genetic variation at 16q24.2 is associated with small vessel stroke published pages: 383-394, ISSN: 0364-5134, DOI: 10.1002/ana.24840	Annals of Neurology 81/3	2020-01-28
2016	Thomas Dalsgaard, Swapnil K. Sonkusare, Cory Teuscher, Matthew E. Poynter, Mark T. Nelson Pharmacological inhibitors of TRPV4 channels reduce cytokine production, restore endothelial function and increase survival in septic mice published pages: , ISSN: 2045-2322, DOI: 10.1038/srep33841	Scientific Reports 6/1	2020-01-28
2017	Steven A. Lubitz, Owen E. Parsons, Christopher D. Anderson, Emelia J. Benjamin, Rainer Malik, Lu-Chen Weng, Martin Dichgans, Cathie L. Sudlow, Peter M. Rothwell, Jonathan Rosand, Patrick T. Ellinor, Hugh S. Markus, Matthew Traylor Atrial Fibrillation Genetic Risk and Ischemic Stroke Mechanisms published pages: 1451-1456, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.016198	Stroke 48/6	2020-01-28
2017	Francesca M. Chappell, Maria del Carmen ValdÃ©s HernÃ¡ndez, Stephen D. Makin, Kirsten Shuler, Eleni Sakka, Martin S. Dennis, Paul A. Armitage, Susana MuÃ±oz Maniega, Joanna M. Wardlaw Sample size considerations for trials using cerebral white matter hyperintensity progression as an intermediate outcome at 1Â year after mild stroke: results of a prospective cohort study published pages: , ISSN: 1745-6215, DOI: 10.1186/s13063-017-1825-7	Trials 18/1	2020-01-28
2017	Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw Early life risk factors for cerebrovascular disease published pages: 976-984, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000003687	Neurology 88/10	2020-01-28
2016	Carmen Capone, Fabrice Dabertrand, Celine Baron-Menguy, Athena Chalaris, Lamia Ghezali, ValÃ©rie Domenga-Denier, Stefanie Schmidt, ClÃ©ment Huneau, Stefan Rose-John, Mark T Nelson, Anne Joutel Mechanistic insights into a TIMP3-sensitive pathway constitutively engaged in the regulation of cerebral hemodynamics published pages: , ISSN: 2050-084X, DOI: 10.7554/eLife.17536	eLife 5	2020-01-28
2016	Chenchen Pan, Ruiyao Cai, Francesca Paola Quacquarelli, Alireza Ghasemigharagoz, Athanasios Lourbopoulos, PaweÅ‚ Matryba, Nikolaus Plesnila, Martin Dichgans, Farida Hellal, Ali ErtÃ¼rk Shrinkage-mediated imaging of entire organs and organisms using uDISCO published pages: 859-867, ISSN: 1548-7091, DOI: 10.1038/nmeth.3964	Nature Methods 13/10	2020-01-28
2017	Caroline A. McHutchison, Ellen V. Backhouse, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw Education, Socioeconomic Status, and Intelligence in Childhood and Stroke Risk in Later Life published pages: 608-618, ISSN: 1044-3983, DOI: 10.1097/EDE.0000000000000675	Epidemiology 28/4	2020-01-28
2017	Renske Uiterwijk, Julie Staals, Marjolein Huijts, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge MRI progression of cerebral small vessel disease and cognitive decline in patients with hypertension published pages: 1263-1270, ISSN: 0263-6352, DOI: 10.1097/HJH.0000000000001294	Journal of Hypertension 35/6	2020-01-28
2017	Susanne J van Veluw, Andy Y Shih, Eric E Smith, Christopher Chen, Julie A Schneider, Joanna M Wardlaw, Steven M Greenberg, Geert Jan Biessels Detection, risk factors, and functional consequences of cerebral microinfarcts published pages: , ISSN: 1474-4422, DOI: 10.1016/S1474-4422(17)30196-5	The Lancet Neurology	2020-01-28
2017	Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff, Maiken Nedergaard Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts published pages: 2870-2877, ISSN: 0270-6474, DOI: 10.1523/JNEUROSCI.2112-16.2017	The Journal of Neuroscience 37/11	2020-01-28
2017	Gordon W. Blair, Maria Valdez Hernandez, Michael J. Thrippleton, Fergus N. Doubal, Joanna M. Wardlaw Advanced Neuroimaging of Cerebral Small Vessel Disease published pages: , ISSN: 1092-8464, DOI: 10.1007/s11936-017-0555-1	Current Treatment Options in Cardiovascular Medicine 19/7	2020-01-28
2017	Maria del C. ValdÃ©s HernÃ¡ndez, Victor GonzÃ¡lez-Castro, Francesca M. Chappell, Eleni Sakka, Stephen Makin, Paul A. Armitage, William H. Nailon, Joanna M. Wardlaw Application of Texture Analysis to Study Small Vessel Disease and Bloodâ€“Brain Barrier Integrity published pages: , ISSN: 1664-2295, DOI: 10.3389/fneur.2017.00327	Frontiers in Neurology 8	2020-01-28
2016	Swapnil K. Sonkusare, Thomas Dalsgaard, Adrian D. Bonev, Mark T. Nelson Inward rectifier potassium (Kir2.1) channels as end-stage boosters of endothelium-dependent vasodilators published pages: 3271-3285, ISSN: 0022-3751, DOI: 10.1113/JP271652	The Journal of Physiology 594/12	2020-01-28
2017	VÃctor GonzÃ¡lez-Castro, MarÃa delÂ C. ValdÃ©s HernÃ¡ndez, FrancescaÂ M. Chappell, PaulÂ A. Armitage, Stephen Makin, JoannaÂ M. Wardlaw Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance published pages: 1465-1481, ISSN: 0143-5221, DOI: 10.1042/CS20170051	Clinical Science 131/13	2020-01-28
2018	Julien Ratelade, Nicolas Mezouar, ValÃ©rie Domenga-Denier, Ambre Rochey, Emmanuelle Plaisier, Anne Joutel Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1-related stroke published pages: 408-420, ISSN: 0022-3417, DOI: 10.1002/path.5023	The Journal of Pathology 244/4	2020-01-28
2018	Juhana FrÃ¶sen, Anne Joutel Smooth muscle cells of intracranial vessels: from development to disease published pages: 501-512, ISSN: 0008-6363, DOI: 10.1093/cvr/cvy002	Cardiovascular Research 114/4	2020-01-28
2018	Kui Kai Lau, Caroline E. Lovelock, Linxin Li, Michela Simoni, Sergei Gutnikov, Wilhelm KÃ¼ker, Henry Ka Fung Mak, Peter M. Rothwell Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review published pages: 1434-1442, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.020104	Stroke 49/6	2020-01-28
2018	Catherine A Humphreys, Maurits A Jansen, Susana MuÃ±oz Maniega, VÃctor GonzÃ¡lez-Castro, Cyril Pernet, Ian J Deary, Rustam Al-Shahi Salman, Joanna M Wardlaw, Colin Smith A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology published pages: 174749301879996, ISSN: 1747-4930, DOI: 10.1177/1747493018799962	International Journal of Stroke	2020-01-28
2018	Enrico Pellegrini, Lucia Ballerini, Maria del C. Valdes Hernandez, Francesca M. Chappell, Victor GonzÃ¡lez-Castro, Devasuda Anblagan, Samuel Danso, Susana MuÃ±oz-Maniega, Dominic Job, Cyril Pernet, Grant Mair, Tom J. MacGillivray, Emanuele Trucco, Joanna M. Wardlaw Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review published pages: 519-535, ISSN: 2352-8729, DOI: 10.1016/j.dadm.2018.07.004	Alzheimer\'s & Dementia: Diagnosis, Assessment & Disease Monitoring 10	2020-01-28
2017	Stephen DJ Makin, Fergus N Doubal, Terence J Quinn, Philip MW Bath, Martin S Dennis, Joanna M Wardlaw The effect of different combinations of vascular, dependency and cognitive endpoints on the sample size required to detect a treatment effect in trials of treatments to improve outcome after lacunar and non-lacunar ischaemic stroke published pages: 66-73, ISSN: 2396-9873, DOI: 10.1177/2396987317728854	European Stroke Journal 3/1	2020-01-28
2018	Humberto Mestre, Jeffrey Tithof, Ting Du, Wei Song, Weiguo Peng, Amanda M. Sweeney, Genaro Olveda, John H. Thomas, Maiken Nedergaard, Douglas H. Kelley Flow of cerebrospinal fluid is driven by arterial pulsations and is reduced in hypertension published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07318-3	Nature Communications 9/1	2020-01-28
2019	Michael Jonathan Thrippleton MRI measurement of blood-brain barrier leakage: minding the gaps published pages: 667-668, ISSN: 0022-3751, DOI: 10.1113/jp277425	The Journal of Physiology 597/3	2020-01-28
2018	Caroline M.J. Loos, Stephen D.J. Makin, Julie Staals, Martin S. Dennis, Robert J. van Oostenbrugge, Joanna M. Wardlaw Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging published pages: 1183-1188, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.020495	Stroke 49/5	2020-01-28
2019	Ganesh Chauhan, Hieab H.H. Adams, Claudia L. Satizabal, Joshua C. Bis, Alexander Teumer, Muralidharan Sargurupremraj, Edith Hofer, Stella Trompet, Saima Hilal, Albert Vernon Smith, Xueqiu Jian, Rainer Malik, Matthew Traylor, Sara L. Pulit, Philippe Amouyel, Bernard Mazoyer, Yi-Cheng Zhu, Sara Kaffashian, Sabrina Schilling, Gary W. Beecham, Thomas J. Montine, Gerard D. Schellenberg, Olafur Kjartans Genetic and lifestyle risk factors for MRI-defined brain infarcts in a population-based setting published pages: e486-e503, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000006851	Neurology 92/5	2020-01-28
2019	Michael Thrippleton, Gordon Blair, Maria Valdes-Hernandez, Andreas Glatz, Scott Semple, Fergus Doubal, Alex Vesey, Ian Marshall, David Newby, Joanna Wardlaw MRI Relaxometry for Quantitative Analysis of USPIO Uptake in Cerebral Small Vessel Disease published pages: 776, ISSN: 1422-0067, DOI: 10.3390/ijms20030776	International Journal of Molecular Sciences 20/3	2020-01-28
2018	Linxin Li, Sarah J.V. Welch, Sergei A. Gutnikov, Ziyah Mehta, Peter M. Rothwell Time course of blood pressure control prior to lacunar TIA and stroke published pages: e1732-e1741, ISSN: 0028-3878, DOI: 10.1212/WNL.0000000000005526	Neurology 90/20	2020-01-28
2018	Ellen V. Backhouse, Caroline A. McHutchison, Vera Cvoro, Susan D. Shenkin, Joanna M. Wardlaw Cognitive ability, education and socioeconomic status in childhood and risk of post-stroke depression in later life: A systematic review and meta-analysis published pages: e0200525, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0200525	PLOS ONE 13/7	2020-01-28
2019	Marios K. Georgakis, Dipender Gill, Kristiina RannikmÃ¤e, Matthew Traylor, Christopher D. Anderson, Jin-Moo Lee, Yoichiro Kamatani, Jemma C. Hopewell, Bradford B. Worrall, JÃ¼rgen Bernhagen, Cathie L. M. Sudlow, Rainer Malik, Martin Dichgans Genetically Determined Levels of Circulating Cytokines and Risk of Stroke published pages: 256-268, ISSN: 0009-7322, DOI: 10.1161/circulationaha.118.035905	Circulation 139/2	2020-01-28
2017	Gordon W Blair, Jason P Appleton, Zhe Kang Law, Fergus Doubal, Katie Flaherty, Richard Dooley, Kirsten Shuler, Carla Richardson, Iona Hamilton, Yulu Shi, Michael Stringer, Julia Boyd, Michael J Thrippleton, Nikola Sprigg, Philip M Bath, Joanna M Wardlaw Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination published pages: 530-538, ISSN: 1747-4930, DOI: 10.1177/1747493017731947	International Journal of Stroke 13/5	2020-01-28
2018	Yulu Shi, Michael J Thrippleton, Gordon W Blair, David A Dickie, Ian Marshall, Iona Hamilton, Fergus N Doubal, Francesca Chappell, Joanna M Wardlaw Small vessel disease is associated with altered cerebrovascular pulsatility but not resting cerebral blood flow published pages: 0271678X1880395, ISSN: 0271-678X, DOI: 10.1177/0271678x18803956	Journal of Cerebral Blood Flow & Metabolism	2020-01-28
2018	Lennart J. Geurts, Alex A. Bhogal, Jeroen C.W. Siero, Peter R. Luijten, Geert Jan Biessels, Jaco J.M. Zwanenburg Vascular reactivity in small cerebral perforating arteries with 7â€¯T phase contrast MRI â€“ A proof of concept study published pages: 470-477, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2018.01.055	NeuroImage 172	2020-01-28
2018	Yulu Shi, MichaelÂ J. Thrippleton, Ian Marshall, JoannaÂ M. Wardlaw Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review published pages: 157-171, ISSN: 0143-5221, DOI: 10.1042/cs20171280	Clinical Science 132/1	2020-01-28
2018	Benjamin A. Plog, Maiken Nedergaard The Glymphatic System in Central Nervous System Health and Disease: Past, Present, and Future published pages: 379-394, ISSN: 1553-4006, DOI: 10.1146/annurev-pathol-051217-111018	Annual Review of Pathology: Mechanisms of Disease 13/1	2020-01-28
2018	Bian Liu, Kui Kai Lau, Linxin Li, Caroline Lovelock, Ming Liu, Wilhelm Kuker, Peter M. Rothwell Age-Specific Associations of Renal Impairment With Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Transient Ischemic Attack and Stroke published pages: 899-904, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.019650	Stroke 49/4	2020-01-28
2018	Alastair J.S. Webb, Sara Mazzucco, Linxin Li, Peter M. Rothwell Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke published pages: 62-67, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.019107	Stroke 49/1	2020-01-28
2018	Caroline A McHutchison, Vera Cvoro, Stephen Makin, Francesca M Chappell, Kirsten Shuler, Joanna M Wardlaw Functional, cognitive and physical outcomes 3 years after minor lacunar or cortical ischaemic stroke published pages: jnnp-2018-319134, ISSN: 0022-3050, DOI: 10.1136/jnnp-2018-319134	Journal of Neurology, Neurosurgery & Psychiatry	2020-01-28
2017	Michael J Thrippleton, Yulu Shi, Gordon Blair, Iona Hamilton, Gordon Waiter, Christian Schwarzbauer, Cyril Pernet, Peter JD Andrews, Ian Marshall, Fergus Doubal, Joanna M Wardlaw Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing published pages: 195-206, ISSN: 1747-4930, DOI: 10.1177/1747493017730740	International Journal of Stroke 13/2	2020-01-28
2019	Farah Francis, Lucia Ballerini, Joanna M Wardlaw Perivascular spaces and their associations with risk factors, clinical disorders and neuroimaging features: A systematic review and meta-analysis published pages: 174749301983032, ISSN: 1747-4930, DOI: 10.1177/1747493019830321	International Journal of Stroke	2020-01-28
2018	EmmaÂ L. Bailey, MartinÂ W. McBride, JohnÂ D. McClure, Wendy Beattie, Delyth Graham, AnnaÂ F. Dominiczak, Colin Smith, JoannaÂ M. Wardlaw Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease published pages: 1315-1328, ISSN: 0143-5221, DOI: 10.1042/cs20171572	Clinical Science 132/12	2020-01-28
2018	Alice M Harper, Lauren Clayson, Joanna M Wardlaw, Maria del C ValdÃ©s HernÃ¡ndez Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology published pages: 3518-3538, ISSN: 0300-0605, DOI: 10.1177/0300060518755623	Journal of International Medical Research 46/9	2020-01-28
2018	Osama F Harraz, Thomas A Longden, David Hill-Eubanks, Mark T Nelson PIP2 depletion promotes TRPV4 channel activity in mouse brain capillary endothelial cells published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.38689	eLife 7	2020-01-28
2017	Vera Zietemann, Anna Kopczak, Claudia MÃ¼ller, Frank Arne Wollenweber, Martin Dichgans Validation of the Telephone Interview of Cognitive Status and Telephone Montreal Cognitive Assessment Against Detailed Cognitive Testing and Clinical Diagnosis of Mild Cognitive Impairment After Stroke published pages: 2952-2957, ISSN: 0039-2499, DOI: 10.1161/strokeaha.117.017519	Stroke 48/11	2020-01-28
2018	Simon R. Cox, Mike Allerhand, Stuart J. Ritchie, Susana MuÃ±oz Maniega, Maria ValdÃ©s HernÃ¡ndez, Sarah E. Harris, David Alexander Dickie, Devasuda Anblagan, Benjamin S. Aribisala, Zoe Morris, Roy Sherwood, N. Joan Abbott, John M. Starr, Mark E. Bastin, Joanna M. Wardlaw, Ian J. Deary Longitudinal serum S100Î² and brain aging in the Lothian Birth Cohort 1936 published pages: 274-282, ISSN: 0197-4580, DOI: 10.1016/j.neurobiolaging.2018.05.029	Neurobiology of Aging 69	2020-01-28
2017	Kristiina RannikmÃ¤e, Vhinoth Sivakumaran, Henry Millar, Rainer Malik, Christopher D. Anderson, Mike Chong, Tushar Dave, Guido J. Falcone, Israel Fernandez-Cadenas, Jordi Jimenez-Conde, Arne Lindgren, Joan Montaner, Martin O\'Donnell, Guillaume ParÃ©, Farid Radmanesh, Natalia S. Rost, Agnieszka Slowik, Martin SÃ¶derholm, Matthew Traylor, Sara L. Pulit, Sudha Seshadri, Brad B. Worrall, Daniel Woo, H COL4A2 is associated with lacunar ischemic stroke and deep ICH published pages: 1829-1839, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000004560	Neurology 89/17	2020-01-28
2018	Andreas Zellner, Eva Scharrer, Thomas Arzberger, Chio Oka, ValÃ©rie Domenga-Denier, Anne Joutel, Stefan F. Lichtenthaler, Stephan A. MÃ¼ller, Martin Dichgans, Christof Haffner CADASIL brain vessels show a HTRA1 loss-of-function profile published pages: 111-125, ISSN: 0001-6322, DOI: 10.1007/s00401-018-1853-8	Acta Neuropathologica 136/1	2020-01-28
2018	Renske Uiterwijk, Julie Staals, Marjolein Huijts, Sander M. J. van Kuijk, Peter W. de Leeuw, Abraham A. Kroon, Robert J. van Oostenbrugge Hypertensive organ damage predicts future cognitive performance: A 9-year follow-up study in patients with hypertension published pages: 1458-1463, ISSN: 1524-6175, DOI: 10.1111/jch.13372	The Journal of Clinical Hypertension 20/10	2020-01-28
2018	Steffen Tiedt, Martin Dichgans Role of Non-Coding RNAs in Stroke published pages: 3098-3106, ISSN: 0039-2499, DOI: 10.1161/strokeaha.118.021010	Stroke 49/12	2020-01-28
2017	Caroline MJ Loos, Caroline McHutchison, Vera Cvoro, Stephen DJ Makin, Julie Staals, Francesca Chappell, Martin S Dennis, Robert J van Oostenbrugge, Joanna M Wardlaw The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke published pages: 518-524, ISSN: 1747-4930, DOI: 10.1177/1747493017730780	International Journal of Stroke 13/5	2020-01-28
2018	Steffen Tiedt, Marco Duering, Christian Barro, Asli Gizem Kaya, Julia Boeck, Felix J. Bode, Matthias Klein, Franziska Dorn, Benno Gesierich, Lars Kellert, Birgit Ertl-Wagner, Michael W. Goertler, Gabor C. Petzold, Jens Kuhle, Frank A. Wollenweber, Nils Peters, Martin Dichgans Serum neurofilament light published pages: e1338-e1347, ISSN: 0028-3878, DOI: 10.1212/wnl.0000000000006282	Neurology 91/14	2020-01-28
2017	Steffen Tiedt, Matthias Prestel, Rainer Malik, Nicola Schieferdecker, Marco Duering, Veronika Kautzky, Ivelina Stoycheva, Julia BÃ¶ck, Bernd H. Northoff, Matthias Klein, Franziska Dorn, Knut Krohn, Daniel Teupser, Arthur Liesz, Nikolaus Plesnila, Lesca Miriam Holdt, Martin Dichgans RNA-Seq Identifies Circulating miR-125a-5p, miR-125b-5p, and miR-143-3p as Potential Biomarkers for Acute Ischemic Stroke published pages: 970-980, ISSN: 0009-7330, DOI: 10.1161/circresaha.117.311572	Circulation Research 121/8	2020-01-28
2019	Martin Dichgans Dementia risk after transient ischaemic attack and stroke published pages: 223-225, ISSN: 1474-4422, DOI: 10.1016/s1474-4422(18)30497-6	The Lancet Neurology 18/3	2020-01-28

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SVDS-AT-TARGET" project.

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Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SVDS-AT-TARGET" are provided by the European Opendata Portal: CORDIS opendata.