DIALOY SIGNED
Mosaic loss of chromosome Y (LOY) in blood cells - a new biomarker for risk of cancer and Alzheimer’s disease in men
Total Cost €
0EC-Contrib. €
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Project "DIALOY" data sheet
The following table provides information about the project.
| Coordinator |
UPPSALA UNIVERSITET
Organization address contact info |
| Coordinator Country | Sweden [SE] |
| Project website | http://www.forsberglab.com |
| Total cost | 1˙525˙000 € |
| EC max contribution | 1˙525˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2015-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-03-01 to 2021-02-28 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UPPSALA UNIVERSITET | SE (UPPSALA) | coordinator | 1˙525˙000.00 |
Map
Project objective
My recent discoveries show that mosaic loss of chromosome Y (LOY) in peripheral blood is associated with increased risks of cancer and Alzheimer’s disease (AD). These conditions are responsible for >50% of morbidity/mortality in aging men. More than 15% of men older than 70 show some degree of LOY and these men survive on average only half as long as men without LOY. Smoking is strongly associated with LOY and remarkably, the fraction of cells with LOY decreases after cessation of smoking. Cells with LOY can be detected, and disease risks predicted, many years before clinical manifestation of disease. These results of associations between LOY, cancer and smoking have been published in Nature Genetics and Science during 2014.
The overall objective of the proposal is to develop LOY as a new, strong and predictive biomarker. To this end, the research program focuses on three objectives: 1) expanding the study of LOY and associations with disease risks in still larger cohorts; 2) investigating functional aspects of LOY; and 3) develop improved technology for LOY-detection. The successful execution of the project is essential before LOY-testing in clinics can be realized.
Diagnosis of cancer and AD in modern medicine is based on clinical symptoms of disease. Through earlier identification of individuals at increased risk for disease, preventive strategies could be applied, before the severe stages appear. Preliminary results affirm the feasibility of the project and provide proof-of-concept that LOY-tests can be used for early identification of men with increased risks for these diseases. In addition to improving diagnostics and therapeutics; implementation of LOY-testing could prevent smoking-related disease and reduce the health care costs. In the end, LOY-testing could decrease male mortality rates and possibly eliminate the sex-difference in life expectancy. The project will therefore benefit individual patients as well as healthcare systems and society at large.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Lars A. Forsberg Back to the drawing board—loss of chromosome Y (LOY) in leukocytes is associated with age-related macular degeneration published pages: , ISSN: 1018-4813, DOI: 10.1038/s41431-018-0261-9 |
European Journal of Human Genetics | 2019-10-08 |
| 2018 |
Lars A. Forsberg, Jonatan Halvardson, Edyta Rychlicka-Buniowska, Marcus Danielsson, Behrooz Torabi Moghadam, Jonas Mattisson, Chiara Rasi, Hanna Davies, Lars Lind, Vilmantas Giedraitis, Lars Lannfelt, Lena Kilander, Martin Ingelsson and Jan P. Dumanski Mosaic loss of chromosome Y in leukocytes matters published pages: , ISSN: 1061-4036, DOI: 10.1038/s41588-018-0267-9 |
Nature Genetics | 2019-10-08 |
| 2019 |
Deborah Thompson, Giulio Genovese, Jonatan Halvardson, Jacob Ulirsch, Daniel Wright, Chikashi Terao, Olafur Davidsson, Felix Day, Patrick Sulem, Yunxuan Jiang, Marcus Danielsson, Hanna Davies, Joe Dennis, Malcolm Dunlop, Douglas Easton, Victoria Fisher, Florian Zink, Richard Houlston, Martin Ingelsson, Siddhartha Kar, Nicola Kerrison, Ragnar Kristjansson, Rong Li, Chey Loveday, Jonas Mattisson, Steven McCarroll, Yoshinori Murakami, Anna Murray, Pawel Olszewski, Edyta Rychlicka-Buniowska, Robert Scott, Unnur Thorsteinsdottir, Ian Tomlinson, Behrooz Torabi Moghadam, Clare Turnbull, Nicholas Wareham, Daniel Gudbjartsson, INTEGRAL-ILCCO, The Breast Cancer Association Consortium, CIMBA, The Endometrial Cancer Association Consortium, The Ovarian Cancer Association Consortium, The PRACTICAL Consortium, The Kidney Cancer GWAS Meta-Analysis Project, eQTLGen Consortium, BIOS Consortium, 23andMe Research Team, Yoichiro Kamatani, Hilary Finucane, Eva Hoffmann, Steve Jackson, Kari Stefansson, Adam Auton, Ken Ong, Mitchell Machiela, Po-Ru Loh, Jan Dumanski, Stephen Chanock, Lars Forsberg, John Perry Genetic predisposition to mosaic Y chromosome loss in blood is associated with genomic instability in other tissues and susceptibility to non-haematological cancers published pages: , ISSN: , DOI: 10.1101/514026 |
2019-05-22 | |
| 2016 |
Lars A. Forsberg, David Gisselsson, Jan P. Dumanski Mosaicism in health and disease — clones picking up speed published pages: 128-142, ISSN: 1471-0056, DOI: 10.1038/nrg.2016.145 |
Nature Reviews Genetics 18/2 | 2019-06-19 |
| 2016 |
Jan P. Dumanski, Jean-Charles Lambert, Chiara Rasi, Vilmantas Giedraitis, Hanna Davies, Benjamin Grenier-Boley, Cecilia M. Lindgren, Dominique Campion, Carole Dufouil, Florence Pasquier, Philippe Amouyel, Lars Lannfelt, Martin Ingelsson, Lena Kilander, Lars Lind, Lars A. Forsberg Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease published pages: 1208-1219, ISSN: 0002-9297, DOI: 10.1016/j.ajhg.2016.05.014 |
The American Journal of Human Genetics 98/6 | 2019-06-19 |
| 2017 |
Lars A. Forsberg Loss of chromosome Y (LOY) in blood cells is associated with increased risk for disease and mortality in aging men published pages: 657-663, ISSN: 0340-6717, DOI: 10.1007/s00439-017-1799-2 |
Human Genetics 136/5 | 2019-06-19 |
| 2017 |
Jan P. Dumanski, Johan Sundström, Lars A. Forsberg Loss of Chromosome Y in Leukocytes and Major Cardiovascular Events published pages: e001820, ISSN: 1942-3268, DOI: 10.1161/CIRCGENETICS.117.001820 |
Circulation: Cardiovascular Genetics 10/4 | 2019-06-19 |
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