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iMDx SIGNED

Microfiber Electrofluidics for Integrated Molecular Diagnostics

Total Cost €

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EC-Contrib. €

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Partnership

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 iMDx project word cloud

Explore the words cloud of the iMDx project. It provides you a very rough idea of what is the project "iMDx" about.

almost    diagnostics    diagnostic    ebola    microelectronics    point    amplified    electrochemical    sequence    textiles    hiv    protein    paper    rely    basically    3d    fabrication    disposable    sheets    nucleic    biomolecules    biomedical    monolithically    cells    care    pricing    dramatically    realizing    lpa    broad    mef    portable    electrofluidics    lamp    proteins    rpa    translation    accessibility    dna    porous    handling    platform    techniques    ligation    rna    storage    resistant    bacteria    readily    structure    nasba    mefs    samples    broaden    breaking    instruments    clinical    microfiber    materials    acid    antibiotic    applicability    manipulation    centralized    imdx    detect    indirect    integrate    diagnosis    molecular    outcome    times    inappropriate    measuring    of    amplification    powerful    zero    specialized    diseases    combined    detection    laboratories    assay    reagents    automated    amplifications    pcr    ground    microfluidics    exist    antibody    proximity    time    skilled   

Project "iMDx" data sheet

The following table provides information about the project.

Coordinator
KUNGLIGA TEKNISKA HOEGSKOLAN 

Organization address
address: BRINELLVAGEN 8
city: STOCKHOLM
postcode: 100 44
website: www.kth.se

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Total cost 1˙499˙180 €
 EC max contribution 1˙499˙180 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2022-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) coordinator 1˙499˙180.00

Map

 Project objective

'Diagnosis of an increasing number of diseases (such as HIV, Ebola and antibiotic resistant bacteria) rely on centralized laboratories with specialized instruments and skilled personnel. This type of clinical analysis with long lead times and high cost is inappropriate for point of care diagnostics. Portable, automated, and disposable devices with integrated molecular diagnostics (iMDx), could solve this problem. Such devices, however, basically do not exist today.

This research program will develop materials, methods, and diagnostic techniques to enable portable integrated molecular diagnostics (iMDx) devices, that are disposable (almost zero-cost), and that can detect a broad range of diseases using DNA amplification. To achieve this, we will develop '3D microfiber electrofluidics (MEF)'. MEFs rely on simple and readily available porous sheets including paper, and textiles. Their fabrication is simple, and yet they are very powerful because they can monolithically integrate 3D microfluidics, 3D microelectronics, electrochemical analysis, storage of reagents / biomolecules, as well as handling and manipulation of cells.

We will develop techniques, using the combined capabilities of MEFs, for real-time DNA amplification and electrochemical DNA detection directly from samples. We will use three amplifications techniques for realizing a comprehensive iMDx platform: i) DNA detection, using established and state of the art amplification methods (e.g. PCR, LAMP, RPA). ii) RNA detection, using 'nucleic acid sequence-based amplification' (NASBA). iii) Protein detection, using antibody to DNA translation through 'proximity ligation assay' LPA, and using the detection of the amplified DNA is the indirect measure of proteins.

The outcome of this program has the potential to be ground breaking, and change the structure of measuring, processing, and pricing of biomedical information, and dramatically broaden its accessibility and applicability. '

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The information about "IMDX" are provided by the European Opendata Portal: CORDIS opendata.

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