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TransQST SIGNED

Translational quantitative systems toxicology to improve the understanding of the safety of medicines - Sofia: 116030

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TransQST project word cloud

Explore the words cloud of the TransQST project. It provides you a very rough idea of what is the project "TransQST" about.

quantitative preclinical model yield models evaluation university battery central interpret happens drug relate structured vivo goals collectively mechanistic exposure outcomes applicability tract toxicological biomarkers curate generating packages human parallel led proven experimental tools setting adopting record translational toxicology 14 perturbed off track physiological scientific kidney read reactions intracellular liver input employing vitro risk definition fit purpose tenet thanks gi pharmacological relevance systems suitable accurately toxicity rigour man efpia adverse brings data biology transqst liverpool core translatability achievement species qst complementarity heart

Project "TransQST" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://transqst.org/
Total cost	17˙327˙874 €
EC max contribution	8˙000˙000 € (46%)
Programme	1. H2020-EU.3.1.7. (Innovative Medicines Initiative 2 (IMI2))
Code Call	H2020-JTI-IMI2-2015-06-two-stage
Funding Scheme	IMI2-RIA
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF LIVERPOOL THE UNIVERSITY OF LIVERPOOL Organization address address: BROWNLOW HILL 765 FOUNDATION BUILDING city: LIVERPOOL postcode: L69 7ZX website: www.liverpool.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LIVERPOOL)	coordinator	1˙620˙350.00
2	UNIVERSITEIT LEIDEN UNIVERSITEIT LEIDEN Organization address address: RAPENBURG 70 city: LEIDEN postcode: 2311 EZ website: www.universiteitleiden.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	1˙060˙725.00
3	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	1˙026˙750.00
4	FUNDACIO INSTITUT MAR D INVESTIGACIONS MEDIQUES IMIM FUNDACIO INSTITUT MAR D INVESTIGACIONS MEDIQUES IMIM Organization address address: Doctor Aiguader 88 city: BARCELONA postcode: 8003 website: www.imim.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	900˙525.00
5	UNIVERSITEIT MAASTRICHT UNIVERSITEIT MAASTRICHT Organization address address: Minderbroedersberg 4-6 city: MAASTRICHT postcode: 6200 MD website: http://www.maastrichtuniversity.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (MAASTRICHT)	participant	675˙300.00
6	CERTARA UK LIMITED CERTARA UK LIMITED Organization address address: ONE LONDON WALL 6TH FLOOR city: LONDON postcode: EC2Y 5EB website: www.certara.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	participant	450˙900.00
7	FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V. FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ E.V. Organization address address: ARDEYSTRASSE 67 city: DORTMUND postcode: 44139 website: http://www.ifado.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (DORTMUND)	participant	350˙250.00
8	UNIVERSITAT WIEN UNIVERSITAT WIEN Organization address address: UNIVERSITATSRING 1 city: WIEN postcode: 1010 website: www.univie.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	350˙250.00
9	SYNAPSE RESEARCH MANAGEMENT PARTNERS SL SYNAPSE RESEARCH MANAGEMENT PARTNERS SL Organization address address: CALLE VELAZQUEZ 94 PLANTA 1 city: MADRID postcode: 28006 website: www.synapse-managers.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	341˙450.00
10	THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Organization address address: WELLINGTON SQUARE UNIVERSITY OFFICES city: OXFORD postcode: OX1 2JD website: www.ox.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (OXFORD)	participant	325˙000.00
11	OCELLO BV OCELLO BV Organization address address: J.H OORTWEG 21 city: LEIDEN postcode: 2333 CH website: www.ocello.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	275˙775.00
12	UNIVERSITATSKLINIKUM HEIDELBERG UNIVERSITATSKLINIKUM HEIDELBERG Organization address address: IM NEUENHEIMER FELD 672 city: HEIDELBERG postcode: 69120 website: www.klinikum.uni-heidelberg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	269˙790.00
13	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	220˙500.00
14	UNIVERSITAETSKLINIKUM AACHEN UNIVERSITAETSKLINIKUM AACHEN Organization address address: Pauwelsstrasse 30 city: AACHEN postcode: 52074 website: www.ukaachen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (AACHEN)	participant	132˙435.00
15	ABBVIE DEUTSCHLAND GMBH & CO KG ABBVIE DEUTSCHLAND GMBH & CO KG Organization address address: MAINZER STR. 81 city: WIESBADEN postcode: 65205 website: http://www.abbvie.de/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (WIESBADEN)	participant	0.00
16	ASTRAZENECA AB ASTRAZENECA AB Organization address address: Vastra Maelarhamnen city: SODERTAELJE postcode: 151 85 website: www.astrazeneca.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (SODERTAELJE)	participant	0.00
17	BOEHRINGER INGELHEIM INTERNATIONALGMBH BOEHRINGER INGELHEIM INTERNATIONALGMBH Organization address address: BINGER STRASSE city: INGELHEIM postcode: 55218 website: www.boehringerâ€ingelheim.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (INGELHEIM)	participant	0.00
18	Eli Lilly and Company Limited Eli Lilly and Company Limited Organization address address: Lilly House, Priestley Road city: Basingstoke postcode: RG24 9NL website: www.lilly.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (Basingstoke)	participant	0.00
19	GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD. Organization address address: Great West Road 980 city: BRENTFORD postcode: TW89GS website: www.gsk.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BRENTFORD)	participant	0.00
20	INSTITUT DE RECHERCHES INTERNATIONALES SERVIER INSTITUT DE RECHERCHES INTERNATIONALES SERVIER Organization address address: RUE CARNOT 50 city: SURESNES postcode: 92284 website: www.servier.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SURESNES)	participant	0.00
21	JANSSEN PHARMACEUTICA NV JANSSEN PHARMACEUTICA NV Organization address address: TURNHOUTSEWEG 30 city: BEERSE postcode: 2340 website: www.janssenpharmaceutica.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BEERSE)	participant	0.00
22	ORION OYJ ORION OYJ Organization address address: ORIONINTIE 1 city: ESPOO postcode: 2200 website: http://www.orion.fi/en/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FI (ESPOO)	participant	0.00
23	SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT Organization address address: Pierre Brossolette 1 city: Chilly Mazarin postcode: 91380 website: www.sanofi-aventis.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (Chilly Mazarin)	participant	0.00

Map

Project objective

TransQST will develop a Quantitative Systems Toxicology (QST) approach, employing pre-existing data where possible, in order to yield new mechanistic insight into drug-induced toxicity. A central tenet of our programme will be to ensure the human physiological and pharmacological relevance of any test system that has been (or will be) used for generating the input data for modelling. By adopting this approach, we will be able to accurately interpret what happens when test systems are perturbed by drug exposure, and ensure translatability of modelling tools. Mechanistic translational biomarkers are a core aspect of our approach and will be applied in parallel with evidence for understanding how to develop, model and apply such biomarkers in a QST setting. The project is structured in 8 work packages to provide the following outcomes: curate the best available experimental data suitable for modelling adverse drug reactionsÍ¾ provide fit-for-purpose QST models that will address key toxicity measures for liver, kidney, heart and GI-tractÍ¾ provide quantitative risk assessment for off-target toxicity in man based on in vitro and in vivo modelsÍ¾ provide a quantitative mechanistic read-across from species (in vivo and in vitro) currently used for the toxicological evaluation of a new drugÍ¾ provide definition and applicability of the human physiological relevance of preclinical test systemsÍ¾ provide a battery of translational biomarkers that can be used for quantitative read-across from in vitro systems to man and which relate to intracellular pathways (and systems) relevant to drug toxicity. Led by the University of Liverpool, TransQST brings together 14 partners, characterized by their scientific rigour and proven track record. Collectively they will enable achievement of the goals of the call, thanks to their complementarity, proven ability to work together (and with EFPIA partners), and their understanding of how to ensure the relevance of QST to human biology.

Publications

List of publications.
year	authors and title	journal	last update
2017	Elisa Passini, Oliver J. Britton, Hua Rong Lu, Jutta Rohrbacher, An N. Hermans, David J. Gallacher, Robert J. H. Greig, Alfonso Bueno-Orovio, Blanca Rodriguez Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2017.00668	Frontiers in Physiology 8	2019-10-15
2017	Elaina M. Maldonado, Vytautas Leoncikas, CiarÃ¡n P. Fisher, J. Bernadette Moore, Nick J. Plant, Andrzej M. Kierzek Integration of Genome Scale Metabolic Networks and Gene Regulation of Metabolic Enzymes With Physiologically Based Pharmacokinetics published pages: 732-746, ISSN: 2163-8306, DOI: 10.1002/psp4.12230	CPT: Pharmacometrics & Systems Pharmacology 6/11	2019-10-15
2018	Terezinha Souza, Panuwat Trairatphisan, Janet PiÃ±ero, Laura I. Furlong, Julio Saez-Rodriguez, Jos Kleinjans, Danyel Jennen Embracing the Dark Side: Computational Approaches to Unveil the Functionality of Genes Lacking Biological Annotation in Drug-Induced Liver Injury published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00527	Frontiers in Genetics 9	2019-10-15
2018	Manuel Pastor, Jordi Quintana, Ferran Sanz Development of an Infrastructure for the Prediction of Biological Endpoints in Industrial Environments. Lessons Learned at the eTOX Project published pages: , ISSN: 1663-9812, DOI: 10.3389/fphar.2018.01147	Frontiers in Pharmacology 9	2019-10-15
2018	Janet PiÃ±ero, Abel Gonzalez-Perez, Emre Guney, Joaquim Aguirre-Plans, Ferran Sanz, Baldo Oliva, Laura I. Furlong Network, Transcriptomic and Genomic Features Differentiate Genes Relevant for Drug Response published pages: , ISSN: 1664-8021, DOI: 10.3389/fgene.2018.00412	Frontiers in Genetics 9	2019-10-15
2019	Ian M. Copple, Wouter den Hollander, Giulia Callegaro, Fiona E. Mutter, James L. Maggs, Amy L. Schofield, Lucille Rainbow, Yongxiang Fang, Jeffrey J. Sutherland, Ewa C. Ellis, Magnus Ingelman-Sundberg, Stephen W. Fenwick, Christopher E. Goldring, Bob van de Water, James L. Stevens, B. Kevin Park Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury published pages: 385-399, ISSN: 0340-5761, DOI: 10.1007/s00204-018-2354-1	Archives of Toxicology 93/2	2019-10-15
2018	Anyue Yin, Akihiro Yamada, Wiro B Stam, Johan G C van Hasselt, Piet H van der Graaf Quantitative systems pharmacology analysis of drug combination and scaling to humans: the interaction between noradrenaline and vasopressin in vasoconstriction published pages: 3394-3406, ISSN: 0007-1188, DOI: 10.1111/bph.14385	British Journal of Pharmacology 175/16	2019-10-15
2018	Janet PiÃ±ero, Laura I Furlong, Ferran Sanz In silico models in drug development: where we are published pages: 111-121, ISSN: 1471-4892, DOI: 10.1016/j.coph.2018.08.007	Current Opinion in Pharmacology 42	2019-10-15

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