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EASY

Epigenetic approach for the treatment of obesity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

EASY project word cloud

Explore the words cloud of the EASY project. It provides you a very rough idea of what is the project "EASY" about.

methyltransferases histone expenditure unclear off genome memory transmission brown budgets spend decades intake translate environmental public etiology burning combine epidemic balance desperately regulation diet it dysregulation obese weight reduce players exceed nutritional exercise shift proteins skills adipose onset stimuli scientific group threefold markers obesity strategies excess knockout meaningfully toward preliminary contributes data amount metabolic fuel dissecting tissue suv420h capability contributor evidences maintenance energy people researcher point therapeutics overrated therapeutic health socio economic genes generation clinical exposure last suv420h1 mice emerge 1980 epigenetic attractive diseases pivotal suv420h2 countries huge treat vivo dissect link societal indicate metabolism 7 gain occurs vitro linked

Project "EASY" data sheet

The following table provides information about the project.

Coordinator	OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Project website	https://research.hsr.it/en/news/discovered-two-epigenetic-regulators-of-metabolism.html
Total cost	168˙277 €
EC max contribution	168˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-SE
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-12-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	168˙277.00

Map

Project objective

It has been estimated a threefold increase in the number of obese people in Europe since the 1980’s. Currently, EU countries spend an average of 7% of their public health budgets on diseases linked to obesity. The socio-economic impact of obesity epidemic cannot be overrated. European societal needs require desperately a shift forward in the field of obesity research to be able to build new therapeutics strategies. Recent scientific evidences point toward a role of epigenetic changes as major contributor in the obesity etiology. In the last decades, a huge amount of data clearly link epigenetic dysregulation to obesity onset. Yet, it remains unclear whether epigenetic dysregulation contributes meaningfully to obesity epidemic. Because weight gain only occurs when energy intake exceed energy expenditure, burning off excess fuel represent an attractive path to reduce obesity when diet and exercise are not enough. My preliminary data indicate the histone methyltransferases Suv420h1 and Suv420h2 as pivotal players in metabolism regulation. By using knockout mice specifically in brown adipose tissue, this project aims at dissecting the role of Suv420h proteins in the etiology of obesity. I will combine in vivo and in vitro analyses and genome wide studies to: 1) dissect the role of Suv420h proteins in the epigenetic regulation of the pathways controlling weight balance in response to nutritional or environmental stimuli; 2) identify genes involved in the generation, maintenance or transmission of the epigenetic memory of exposure; 3) provide useful markers or therapeutic targets to treat obesity and metabolic diseases. My results have the potential to translate into therapeutics. This research will contribute to provide new clinical targets against obesity. The Experienced Researcher will emerge from the project with new skills, and the capability to lead her own research group.

Publications

List of publications.
year	authors and title	journal	last update
2019	Simona Pedrotti, Roberta Caccia, Maria Victoria Neguembor, Jose Manuel Garcia-Manteiga, Giulia Ferri, Clara de Palma, Tamara Canu, Matteo Giovarelli, Paolo Marra, Amleto Fiocchi, Ivan Molineris, Michele Raso, Francesca Sanvito, Claudio Doglioni, Antonio Esposito, Emilio Clementi, Davide Gabellini The Suv420h histone methyltransferases regulate PPAR-Î³ and energy expenditure in response to environmental stimuli published pages: eaav1472, ISSN: 2375-2548, DOI: 10.1126/sciadv.aav1472	Science Advances 5/4	2020-03-23

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The information about "EASY" are provided by the European Opendata Portal: CORDIS opendata.