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INIMUD SIGNED

Impact of Neuromedin U in type 2 immunity and mucosal defence

Total Cost €

EC-Contrib. €

Partnership

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INIMUD project word cloud

Explore the words cloud of the INIMUD project. It provides you a very rough idea of what is the project "INIMUD" about.

players peptides function cues strikingly molecular preliminary therapeutic group perceived environment perceive genetic mostly regulator neuron curie cells cellular r1 public lymphoid mice environmental signaling data cytokine barriers interplay nevertheless driving nmu employ reveal programmed neuromedin defense gain neuronal preserve orchestrated ilc2 integrate innate disorders unexplored marie mucosal critical decipher sense mutant exert tissue hypothesize health inflammation homeostasis fellowship receptor

Project "INIMUD" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	148˙635 €
EC max contribution	148˙635 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	148˙635.00

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Project objective

Group 2 innate lymphoid cells (ILC2) are critical players in mucosal defense, tissue homeostasis and inflammation. ILC2 development and function have been widely perceived to be programmed. Nevertheless, how ILC2 perceive, integrate and respond to environmental cues remains mostly unexplored. Here we hypothesize that ILC2 sense their environment and exert their function as part of a novel neuronal-ILC2 unit orchestrated by neuromedin U (NmU) signaling. We propose to employ genetic, cellular and molecular approaches to decipher how NmU and its receptor Neuromedin Receptor 1 (Nmu-R1) set ILC2 function and preserve tissue homeostasis at mucosal barriers. To this end, ILC2-specific loss and gain of function mutant mice for Nmu-R1 will be used. Strikingly, preliminary data demonstrate that NmU is a major regulator driving ILC2 cytokine production. Under this Marie-Curie fellowship, we aim to establish a novel molecular interplay between neuron derived peptides and ILC2 function in mucosal homeostasis. Finally, this proposal will reveal new pathways with potential therapeutic value in mucosal disorders that are major public health concerns.

Publications

List of publications.
year	authors and title	journal	last update
2017	VÃ¢nia Cardoso, Julie ChesnÃ©, HÃ©lder Ribeiro, Bethania GarcÃa-Cassani, TÃ¢nia Carvalho, Tiffany Bouchery, Kathleen Shah, Nuno L. Barbosa-Morais, Nicola Harris, Henrique Veiga-Fernandes Neuronal regulation of type 2 innate lymphoid cells via neuromedin U published pages: 277-281, ISSN: 0028-0836, DOI: 10.1038/nature23469	Nature 549/7671	2019-09-04

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