mRNP-PackArt SIGNED
Nuclear mRNA Packaging and mRNP Architecture
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0mRNP-PackArt project word cloud
Explore the words cloud of the mRNP-PackArt project. It provides you a very rough idea of what is the project "mRNP-PackArt" about.
Project "mRNP-PackArt" data sheet
The following table provides information about the project.
| Coordinator |
JUSTUS-LIEBIG-UNIVERSITAET GIESSEN
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Total cost | 1˙991˙387 € |
| EC max contribution | 1˙991˙387 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-06-01 to 2023-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | JUSTUS-LIEBIG-UNIVERSITAET GIESSEN | DE (GIESSEN) | coordinator | 1˙991˙387.00 |
Map
Project objective
An important step of gene expression is the formation of a messenger ribonucleoprotein particle (mRNP). The messenger RNA (mRNA) is synthesized by RNA polymerase II transcribing a protein-coding gene. The mRNA is processed, i.e. capped, spliced and polyadenylated, and packaged into an mRNP by binding of RNA-binding proteins (RBPs). The RBPs bound to the mRNA are essential for the stability of the mRNP, control nuclear mRNA export and often determine cytoplasmic processes such as mRNA localization, translation and decay. Thus, the formation and composition of an mRNP is important for the posttranscriptional control of gene expression. Despite its essential nature, the mechanism of nuclear mRNP packaging and the architecture of an mRNP are still poorly understood due to the fact that mRNPs contain many different mRNAs. The overall goal of this proposal is to elucidate the mechanism of mRNP formation and the molecular structure of an mRNP. Specifically, In aim 1, we will determine and quantify the protein composition of a specific mRNP including different stages during its biogenesis; In aim 2, we will illuminate the molecular mechanism of mRNP packaging; and In aim 3, we will elucidate the architecture of an mRNP by cross-linking mass spectrometry and electron microscopy. These aims will be achieved by combining novel RNP purification strategies and the powerful biochemistry of the model organism S. cerevisiae to purify a specific mRNP with recent advances in high-end mass spectrometry and electron microscopy. In summary, the expected results of this project will show the architecture of an mRNP in its dynamic nature. mRNP packaging will be understood for the first time on a mechanistic as well as structural level. Thus, the results of this project will break new ground in our understanding of this fundamental cellular process and will also provide insights into how defects in this process lead to disease.
Deliverables
| Research Data | Open Research Data Pilot | 2019-10-01 09:18:44 |
Take a look to the deliverables list in detail: detailed list of mRNP-PackArt deliverables.
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MRNP-PACKART" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "MRNP-PACKART" are provided by the European Opendata Portal: CORDIS opendata.