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Io-EMP

Tissue-derived acellular micro-scaffold technology reducing or eliminating diabetics’ dependence oninsulin therapy

Total Cost €

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EC-Contrib. €

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Partnership

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 Io-EMP project word cloud

Explore the words cloud of the Io-EMP project. It provides you a very rough idea of what is the project "Io-EMP" about.

producing    islets    lifetime    dependence    function    stromal    researched    micro    eliminate    t1dm    basic    millions    composition    medical    annually    150    reduce    onset    alone    eyes    cadavers    diabetes    cardiovascular    autoimmune    with    almost    diabetics    worldwide    seeded    connective    14    immunosuppression    bn    performance    clusters    beta    harvested    insulinproducing    functioning    careful    organ    diagnosed    daily    stroma    80    extend    transplantation    acellular    kidneys    complications    17    destruction    therapy    chronic    uncertain    followed    stop    premature    70    24hrs    people    free    damage    properly    premise    source    pancreatic    nutrients    house    cells    naked    unstable    nerves    gases    mitigate    lost    afflicted    appropriate    mission    prepare    harvesting    death    pancreas    10    tissue    scaffolds    architecture    microns    insulin    scaffold    environment    cell    recipients    prevent    disease    procedure    income    immediately    attempt    proprietary    regime    mn    injecting    platform    transplanted    treatment    islet    life    lifestyle    preserve    betalin   

Project "Io-EMP" data sheet

The following table provides information about the project.

Coordinator
BETALIN THERAPEUTICS LTD 

Organization address
address: 3 MENACHEM BEGIN
city: RAMAT GAM
postcode: 5268101
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Project website http://www.betalintherapeutics.com/
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.2.1.5. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced manufacturing and processing)
2. H2020-EU.2.1.3. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies - Advanced materials)
3. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
4. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-11-01   to  2018-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BETALIN THERAPEUTICS LTD IL (RAMAT GAM) coordinator 50˙000.00

Map

 Project objective

Betalin’s mission is to provide a tissue-derived acellular micro-scaffold that will extend the life and the insulin-producing performance of transplanted beta cells in order to reduce or eliminate the dependence of some diabetics on insulin therapy. Type 1 Diabetes is a chronic disease that results from the autoimmune destruction of the insulin-producing beta cells in the pancreas. Its cause is still uncertain and there is no known way to prevent its onset. With~70,000 new cases diagnosed each year, it is estimated that ~17 mn people worldwide are afflicted with T1DM. In the US alone, T1DM results in $14.4 bn in medical costs and lost income annually. Type 1 diabetics face a lifetime regime of insulin therapy and very careful lifestyle management in an attempt to mitigate the long-term complications associated with T1DM such as cardiovascular disease, damage to the eyes, kidneys and nerves, and premature death. In recent years islet transplantation has been researched as a treatment for T1DM. The procedure involves injecting millions of islets (the pancreatic cell clusters that “house” the insulinproducing beta cells) harvested from cadavers, followed by immunosuppression therapy. Islet transplantation is a promising approach but the naked islets are very unstable: they must be transplanted almost immediately after harvesting and up to 80% of the transplanted islets stop functioning within 24hrs. The result is that, after five years, less than 10% of the recipients are free of daily insulin treatment. Betalin’s technology is based on the premise that in order for beta cells to function properly it is necessary to provide an appropriate stromal (connective tissue) micro-environment. The proprietary platform technology is a method to prepare acellular organ-derived micro-scaffolds that preserve the architecture and the basic composition of organ stroma and ensure that no seeded cell will be more than 150 microns from a source of nutrients and gases.

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The information about "IO-EMP" are provided by the European Opendata Portal: CORDIS opendata.

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