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FlyGutHomeostasis SIGNED

Identification of paracrine and systemic signals controlling adult stem cell activity and organ homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FlyGutHomeostasis project word cloud

Explore the words cloud of the FlyGutHomeostasis project. It provides you a very rough idea of what is the project "FlyGutHomeostasis" about.

gastrointestinal    mammalian    model    ecs    steady    knockdown    models    homeostasis    isc    enteroblasts    metabolism    environmental    cell    visceral    vms    gi    reveal    proliferative    flies    activation    function    mammals    tightly    encoding    multiple    ebs    genes    couplings    paradigm    couple    coupling    proliferation    ees    systemic    health    self    adult    stress    tissue    insects    renewal    relays    epithelial    enteroendocrine    prime    niche    remarkable    tnfr    circuitries    coupled    stem    final    vertebrate    organ    renewing    divergence    gut    due    pathological    behavior    communication    feasible    disease    secreted    balance    membrane    deciphering    organismal    ee    fly    independent    muscles    inputs    proteins    screens    peptides    intestinal    feeding    systematic    saturating    potentially    nutrient    despite    local    shown    organs    fitness    cells    challenged    suited    ageing    rnais    released    enterocytes    turnover    physiological    transmembrane    molecular    infection    division    ligand    signals    capacity    inter    energy    physiology   

Project "FlyGutHomeostasis" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙498˙964 €
 EC max contribution 1˙498˙964 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙498˙964.00

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 Project objective

Due to its remarkable self-renewing capacity, the fly gut has recently become a prime paradigm for studying stem-cell function during adult tissue homeostasis. This capacity for self-renewal relays on the proliferative activity of the intestinal stem cells (ISC), which is tightly coupled with cell loss to maintain intestinal homeostasis. ISC proliferation is controlled by multiple local and systemic signals released from the ISC niche (enterocytes (ECs), enteroendocrine (EE) cells, enteroblasts (EBs), and visceral muscles (VMs)) and non-gastrointestinal (non-GI) organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. As a saturating approach to identify local and systemic signals controlling intestinal homeostasis in steady-state and challenged conditions, RNAis will be used to known down all genes encoding secreted peptides specifically in ECs, EEs, or VMs and all genes encoding transmembrane and membrane-associated proteins in the VMs. The proposed screens should identify novel intra- and inter-organ circuitries allowing communication between the gut and other organs to provide organismal health. In addition, the systematic knockdown of secreted peptides from the ISC niche could identify gut-derived signals that couple changes in environmental inputs, such as nutrient availability, with systemic changes in feeding behavior, energy balance, and metabolism. Since large-scale approaches are not feasible in vertebrate models, the signals identified in the above screens could potentially reveal novel couplings contributing to mammalian GI homeostasis and disease. The final part of the proposed project aims a deciphering the molecular signals coupling epithelial fitness with ligand-independent TNFR activation to control ISC division and epithelial turnover in steady-state, challenged and pathological conditions.

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The information about "FLYGUTHOMEOSTASIS" are provided by the European Opendata Portal: CORDIS opendata.

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