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FlyGutHomeostasis SIGNED

Identification of paracrine and systemic signals controlling adult stem cell activity and organ homeostasis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 FlyGutHomeostasis project word cloud

Explore the words cloud of the FlyGutHomeostasis project. It provides you a very rough idea of what is the project "FlyGutHomeostasis" about.

flies    deciphering    function    peptides    activation    secreted    couplings    visceral    molecular    health    ee    homeostasis    ebs    ageing    behavior    systematic    environmental    enteroblasts    despite    enteroendocrine    physiology    signals    vertebrate    independent    proliferation    steady    proliferative    ees    couple    cells    enterocytes    gi    disease    mammals    relays    fitness    stress    intestinal    potentially    division    suited    released    rnais    tnfr    feeding    vms    model    renewing    inputs    isc    remarkable    stem    organismal    turnover    coupled    prime    divergence    reveal    nutrient    knockdown    balance    inter    local    circuitries    tightly    ligand    gut    paradigm    epithelial    cell    due    final    organ    systemic    challenged    metabolism    gastrointestinal    coupling    capacity    communication    feasible    proteins    ecs    transmembrane    organs    multiple    infection    shown    self    screens    encoding    models    membrane    adult    insects    pathological    energy    fly    niche    genes    mammalian    physiological    saturating    renewal    tissue    muscles   

Project "FlyGutHomeostasis" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙498˙964 €
 EC max contribution 1˙498˙964 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2018-STG
 Funding Scheme ERC-STG
 Starting year 2019
 Duration (year-month-day) from 2019-02-01   to  2024-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙498˙964.00

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 Project objective

Due to its remarkable self-renewing capacity, the fly gut has recently become a prime paradigm for studying stem-cell function during adult tissue homeostasis. This capacity for self-renewal relays on the proliferative activity of the intestinal stem cells (ISC), which is tightly coupled with cell loss to maintain intestinal homeostasis. ISC proliferation is controlled by multiple local and systemic signals released from the ISC niche (enterocytes (ECs), enteroendocrine (EE) cells, enteroblasts (EBs), and visceral muscles (VMs)) and non-gastrointestinal (non-GI) organs. Despite the physiological divergence between insects and mammals, studies have shown that flies represent a model that is well suited for studying stem cell physiology during ageing, stress, and infection. As a saturating approach to identify local and systemic signals controlling intestinal homeostasis in steady-state and challenged conditions, RNAis will be used to known down all genes encoding secreted peptides specifically in ECs, EEs, or VMs and all genes encoding transmembrane and membrane-associated proteins in the VMs. The proposed screens should identify novel intra- and inter-organ circuitries allowing communication between the gut and other organs to provide organismal health. In addition, the systematic knockdown of secreted peptides from the ISC niche could identify gut-derived signals that couple changes in environmental inputs, such as nutrient availability, with systemic changes in feeding behavior, energy balance, and metabolism. Since large-scale approaches are not feasible in vertebrate models, the signals identified in the above screens could potentially reveal novel couplings contributing to mammalian GI homeostasis and disease. The final part of the proposed project aims a deciphering the molecular signals coupling epithelial fitness with ligand-independent TNFR activation to control ISC division and epithelial turnover in steady-state, challenged and pathological conditions.

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The information about "FLYGUTHOMEOSTASIS" are provided by the European Opendata Portal: CORDIS opendata.

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