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PAMpeR SIGNED

Patroller monocytes as modulators of diabetic retinopathy

Total Cost €

EC-Contrib. €

Partnership

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PAMpeR project word cloud

Explore the words cloud of the PAMpeR project. It provides you a very rough idea of what is the project "PAMpeR" about.

trophic preceded lower dm protective nonproliferative investigation preferentially variance profile monocyte damage data classic adults capture diabetes indicate period patroller incorporate suggested endothelium t1dm subjects protect magnitude active vascular preliminary enabled patients biosynthetic discrete applicability repairing first actions speed relation healing healthy delivered time efficacy setting transcriptional blindness circulating seek leukostasis dr activates functional diabetic inflammatory latency monocytes repair losing complement protecting complication mimic vessels clinical subpopulation types cells cytokines rolling human compare endogenous initial subset patrollers beneficial crawling months leverage fact retinopathy natural start suggest housekeeping molecular adapt expectation patrol contrast retinal history

Project "PAMpeR" data sheet

The following table provides information about the project.

Coordinator	OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	180˙277 €
EC max contribution	180˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-SE
Starting year	2018
Duration (year-month-day)	from 2018-05-16 to 2020-05-15

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	180˙277.00

Map

Project objective

'Diabetic retinopathy is the first vascular complication of diabetes and the leading cause of legal blindness among adults in Europe. The fact that diabetic retinopathy is preceded by a long latency period has suggested to us that its natural history could incorporate a phase of vascular repair, active after short duration of diabetes and eventually losing efficacy over time. “Patroller” monocytes, a discrete subpopulation of circulating monocytes, patrol healthy vessels by “crawling” on the endothelium at a speed that is order of magnitude lower than rolling, and at variance with the 'classic' monocyte subset produce preferentially housekeeping and trophic factors rather than inflammatory cytokines. Our preliminary data strongly support a role of patrollers, in protecting and repairing retinal vessels in diabetes; suggest that the beneficial activities are delivered during leukostasis; and indicate that 5 months of diabetes duration activates a healing/protective transcriptional program in patrollers.

I seek to learn whether the biosynthetic profile of patrollers changes in relation to increasing duration of diabetes and evolving retinal vascular damage; and, most importantly, I seek to bring the study of patrollers to clinical investigation.

The Objectives are to: 1. Learn if circulating patrollers adapt their biosynthetic profile to different diabetes duration (3 and 9 months) and to the evolving vascular damage 2. Bring the project to clinical applicability by start setting up a human study that aims to compare and contrast the number of circulating patrollers, as well as selected biosynthetic and functional characteristics of these cells, in T1DM patients with no DR after 4-8 years of DM, in T1DM patients with initial nonproliferative DR, and in healthy control subjects.

The expectation is to capture from endogenous systems the types of molecular actions that protect the vessels in early diabetes; and thus be enabled to mimic, complement, or leverage'

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The information about "PAMPER" are provided by the European Opendata Portal: CORDIS opendata.