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VOILA SIGNED
Validation of Innovative Lipopeptide Antibiotics
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0VOILA project word cloud
Explore the words cloud of the VOILA project. It provides you a very rough idea of what is the project "VOILA" about.
worldwide
pd
natural
alarming
semisynthetic
efficacy
enabled
appropriate
staggering
action
bacteria
resistant
2050
proof
business
global
voila
stability
feasibility
comprising
cog
semisynthetically
lipopeptide
emergence
lose
threat
antibiotics
superbugs
antimicrobial
compound
significantly
opportunity
class
safety
pk
pathogens
applicability
possess
propensity
models
vivo
intervention
preliminary
lower
deaths
combat
mode
evaluation
parent
haemolytic
family
apart
dangerous
nisin
million
health
modify
undesired
erc
viability
antibiotic
commercial
potency
compounds
resistance
with
broad
drug
rates
innovative
data
entirely
lipid
shows
clinically
animal
eliminated
platform
eskape
strategies
mediated
Project "VOILA" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT LEIDEN
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 150˙000 € |
| EC max contribution | 150˙000 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2018-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2019 |
| Duration (year-month-day) | from 2019-04-01 to 2020-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT LEIDEN | NL (LEIDEN) | coordinator | 150˙000.00 |
Map
Project objective
Antibiotic resistance presents a growing threat to global health. The emergence of the superbugs is alarming: at current rates of increase, and without new intervention strategies, antibiotic resistance could cause a staggering 10 million deaths/year worldwide by 2050. Therefore, new approaches need to be developed to combat antibiotic resistance, particularly for the WHO’s priority pathogens which include the so-called ESKAPE family of dangerous drug-resistant bacteria.
Recently, we developed a novel technology platform comprising a set of methodologies to semisynthetically modify the natural antibiotic nisin. In doing so we generated novel lipopeptide antibiotics with a much higher in vivo stability than the parent compound. These semisynthetic antibiotics possess a lipid II-mediated mode of action similar to nisin, which sets them apart from any current clinically-used antibiotic. During my ERC CoG, we have significantly improved these compounds, i.e. increased their antimicrobial activity and eliminated undesired haemolytic effects. Importantly, preliminary data shows that these antibiotics have a lower propensity to lose their potency due to antibiotic resistance development. I propose that these innovative lipopeptide antibiotics present a significant step forward in addressing the alarming threat of antibiotic resistance. However, to establish their commercial viability and broad applicability, the efficacy and preliminary safety of the new compounds need to be addressed. This can best be achieved via a PK/PD proof of concept study in appropriate animal models along with with a detailed evaluation of the business opportunity.
The main objective of VOILA is therefore to establish both the technical feasibility and commercial viability of an entirely new class of lipopeptide antibiotics that is enabled by our innovative technology platform.
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The information about "VOILA" are provided by the European Opendata Portal: CORDIS opendata.
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