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HESSP SIGNED

Hippocampus Extracellular Space Simulator Project (HESSP)

Total Cost €

EC-Contrib. €

Partnership

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HESSP project word cloud

Explore the words cloud of the HESSP project. It provides you a very rough idea of what is the project "HESSP" about.

eligible biophysical extracellular neurons exists formed scientific interdisciplinary tested drugs fet released hippocampus dysfunction flagship century frontier es earliest diffusion proposing science simulates successful plays understanding scientists alzheimer line neuropharmacology chosen blood metabolite hessp additionally structure chemical union clearance neurodegenerative diffuse neuroscience barrier disease simulator researcher mouse brain simulation software substances endeavor architecture simulate hbp 21st lack led create human diseases biggest pass acquire pharmacology improves space ad covered university computer launch host

Project "HESSP" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD DE SALAMANCA Organization address address: CALLE PATIO DE ESCUELAS 1 city: SALAMANCA postcode: 37008 website: www.usal.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	245˙732 €
EC max contribution	245˙732 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2019
Funding Scheme	MSCA-IF-GF
Starting year	2020
Duration (year-month-day)	from 2020-09-01 to 2023-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD DE SALAMANCA UNIVERSIDAD DE SALAMANCA Organization address address: CALLE PATIO DE ESCUELAS 1 city: SALAMANCA postcode: 37008 website: www.usal.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (SALAMANCA)	coordinator	245˙732.00
2	THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK Organization address address: STATE STREET 35 city: ALBANY NY postcode: 12201 website: http://cnse.albany.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (ALBANY NY)	partner	0.00

Map

Project objective

Understanding the human brain is one of the biggest scientific challenges of the 21st century, and this endeavor has led the European Union to launch the Human Brain Project (HBP) as a FET flagship project. However, even a flagship project such as the HBP cannot study all aspects of the human brain. One aspect that is not covered by the HBP is the extracellular space (ES). The ES of the brain is important in the field of neuropharmacology because it is key to the successful delivery of drugs to the neurons. Also, the importance of the metabolite clearance activity of the ES has led to proposing that a dysfunction of this process plays a role in neurodegenerative diseases. However, to the best of the eligible researcher’s knowledge, no initiative exists to create an ES simulation software that improves the research. To address this lack of simulation software, this proposal presents the Hippocampus Extracellular Space Simulator Project (HESSP). The HESSP’s goal is to develop a simulation software for how substances released by neurons and chemical substances that pass the blood-brain barrier diffuse through the ES. Specifically, the HESSP will create a software that simulates the diffusion process in the ES of the mouse’s hippocampus. The HESSP is an interdisciplinary project that involves computer science, neuroscience and pharmacology, and it addresses the challenge of developing a software architecture to simulate a diffusion process highly complex due to its number of elements formed. The hippocampus was chosen because it is a well-known structure, the results can be tested, and it is the earliest brain structure affected in Alzheimer’s disease (AD). The HESSP will open a frontier line of research at the host university in collaboration with leading scientists in ES and neurodegenerative diseases. Additionally, the eligible researcher will acquire frontier knowledge in the simulation of complex biophysical processes and in neuroscience.

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The information about "HESSP" are provided by the European Opendata Portal: CORDIS opendata.

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