Explore the words cloud of the EYE-RISK project. It provides you a very rough idea of what is the project "EYE-RISK" about.
The following table provides information about the project.
Coordinator |
EBERHARD KARLS UNIVERSITAET TUEBINGEN
Organization address contact info |
Coordinator Country | Germany [DE] |
Project website | http://www.eyerisk.eu |
Total cost | 6˙069˙996 € |
EC max contribution | 5˙972˙496 € (98%) |
Programme |
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease) |
Code Call | H2020-PHC-2014-two-stage |
Funding Scheme | RIA |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-01 to 2019-04-30 |
Take a look of project's partnership.
Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention and therapy for AMD: (a) the development of robust algorithms utilising genetic and non-genetic risk factors to identify personalised risks of developing advanced wet and dry AMD; (b) the identification of novel biomarkers for further stratification of disease risks. New insights from (a)(b) will be used to elaborate preventive medical recommendations for highrisk subgroups of AMD patients; and (c) the identification of molecular drivers/biological pathways relevant for onset and progression of advanced AMD that will be used to identify and validate new therapeutic targets.
Key deliverables are: 1. Determination of AMD frequency in Europe, and assessment of AMD risk for phenotypical, genetic, environmental, and biochemical risk factors and their interaction. (WP1-3) 2. Development of a web-based prediction model for personalised risk assessment of AMD based on integration of risk profiles derived from retinal imaging, molecular genetics, assessment of lifestyle, and biochemical testing. (WP4) 3. Modelling and functional characterisation of pathophysiological pathways identified from integrated analysis of current knowledge and the above risk profiles. (WP5) 4. Experimental testing and interpretation of pathophysiological consequences of risks at the molecular level. (WP6) 5. An extension and refinement of the prediction model (WP4) based on work in WP5 and WP6 to generate clinical guidelines for the medical management of high-risk subgroups of patients with AMD. (WP7) 6. Promotion and dissemination of newly gained knowledge towards AMD prevention and therapy development
Workshops | Other | 2020-04-01 17:16:16 |
EYE-RISK website | Websites, patent fillings, videos etc. | 2020-04-01 17:16:16 |
Dissemination | Documents, reports | 2020-04-01 17:16:16 |
Take a look to the deliverables list in detail: detailed list of EYE-RISK deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Jordi Monés, Marc Biarnés The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation published pages: 40, ISSN: 2164-2591, DOI: 10.1167/tvst.7.6.40 |
Translational Vision Science & Technology 7/6 | 2020-04-01 |
2019 |
Eveline Kersten, Sascha Dammeier, Soufiane Ajana, Joannes M. M. Groenewoud, Marius Codrea, Franziska Klose, Yara T. Lechanteur, Sascha Fauser, Marius Ueffing, Cécile Delcourt, Carel B. Hoyng, Eiko K. de Jong, Anneke I. den Hollander Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway published pages: e0218457, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218457 |
PLOS ONE 14/6 | 2020-04-01 |
2018 |
Eveline Kersten, Maartje J. Geerlings, Marc Pauper, Jordi Corominas, Bjorn Bakker, Lebriz Altay, Sascha Fauser, Eiko K. de Jong, Carel B. Hoyng, Anneke I. den Hollander Genetic screening for macular dystrophies in patients clinically diagnosed with dry ageâ€related macular degeneration published pages: 569-574, ISSN: 0009-9163, DOI: 10.1111/cge.13447 |
Clinical Genetics 94/6 | 2020-04-01 |
2018 |
Philip J. Luthert, Luis Serrano, Christina Kiel Opportunities and Challenges of Whole-Cell and -Tissue Simulations of the Outer Retina in Health and Disease published pages: 131-152, ISSN: 2574-3414, DOI: 10.1146/annurev-biodatasci-080917-013356 |
Annual Review of Biomedical Data Science 1/1 | 2020-04-01 |
2019 |
Thomas J. Heesterbeek, Eiko K. de Jong, Ilhan E. Acar, Joannes M. M. Groenewoud, Bart Liefers, Clara I. Sánchez, Tunde Peto, Carel B. Hoyng, Daniel Pauleikhoff, Hans W. Hense, Anneke I. den Hollander Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43144-3 |
Scientific Reports 9/1 | 2020-04-01 |
2019 |
Bénédicte M.J. Merle, Johanna M. Colijn, Audrey Cougnard-Grégoire, Alexandra P.M. de Koning-Backus, Marie-Noëlle Delyfer, Jessica C. Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H. Franco, Jean-François Korobelnik, Caroline C.W. Klaver, Cécile Delcourt, Soufiane Ajana, Blanca Arango-Gonzalez, Angela Armento, Verena Arndt, Vaibhav Bhatia, Shom Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration published pages: 381-390, ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2018.08.006 |
Ophthalmology 126/3 | 2020-04-01 |
2018 |
Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre Lengyel A new perspective on lipid research in age-related macular degeneration published pages: , ISSN: 1350-9462, DOI: 10.1016/j.preteyeres.2018.04.006 |
Progress in Retinal and Eye Research | 2020-04-01 |
2017 |
Eveline Kersten, Maartje J. Geerlings, Anneke I. den Hollander, Eiko K. de Jong, Sascha Fauser, Tunde Peto, Carel B. Hoyng Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene published pages: 1037, ISSN: 2168-6165, DOI: 10.1001/jamaophthalmol.2017.3195 |
JAMA Ophthalmology 135/10 | 2020-04-01 |
2018 |
Geerlings, Maartje J.; Kersten, Eveline; Groenewoud, Joannes M.M.; Fritsche, Lars G.; Hoyng, Carel B.; de Jong, Eiko K.; den Hollander, Anneke I. Geographic distribution of rare variants associated with age-related macular degeneration published pages: 75-82, ISSN: 1090-0535, DOI: |
Molecular Vision 24 | 2020-04-01 |
2018 |
Jordi Corominas, Johanna M. Colijn, Maartje J. Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A.M. Verlouw, Jeroen G.J. van Rooij, Robert Kraaij, Paulus T.V.M. de Jong, Albert Hofman, Johannes R. Vingerling, Tina Schick, Sascha Fauser, Eiko K. de Jong, Cornelia M. van Duijn, Carel B. Hoyng, Caroline C.W. Klaver, Anneke I. den Hollander Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1 , a Component of Bruch’s Membrane published pages: , ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2018.03.040 |
Ophthalmology | 2020-04-01 |
2017 |
Eveline Kersten, Constantin C. Paun, Rosa L. Schellevis, Carel. B. Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C.W. Klaver, Sascha Dammeier, Anneke I. den Hollander, Eiko K. de Jong Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration published pages: , ISSN: 0039-6257, DOI: 10.1016/j.survophthal.2017.05.003 |
Survey of Ophthalmology | 2020-04-01 |
2017 |
Jordi Monés, MÃriam Garcia, Marc Biarnés, Aparna Lakkaraju, Lucia Ferraro Drusen Ooze: A Novel Hypothesis in Geographic Atrophy published pages: , ISSN: 2468-6530, DOI: 10.1016/j.oret.2017.02.006 |
Ophthalmology Retina | 2020-04-01 |
2017 |
Jordi Monés, Marc Biarnés Geographic atrophy phenotype identification by cluster analysis published pages: bjophthalmol-201, ISSN: 0007-1161, DOI: 10.1136/bjophthalmol-2017-310268 |
British Journal of Ophthalmology | 2020-04-01 |
2017 |
Matthew G. Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C. Knowles, Jeffrey D. Messinger, Russell W. Read, Clyde Guidry, Christine A. Curcio Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model published pages: 708, ISSN: 1552-5783, DOI: 10.1167/iovs.16-21060 |
Investigative Opthalmology & Visual Science 58/2 | 2020-04-01 |
2016 |
Elod Kortvely, Stefanie M. Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing The unconventional secretion of ARMS2 published pages: ddw162, ISSN: 0964-6906, DOI: 10.1093/hmg/ddw162 |
Human Molecular Genetics | 2020-04-01 |
2017 |
Johanna M. Colijn, Gabriëlle H.S. Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L. Cachulo, Anthony P. Khawaja, Audrey Cougnard-Gregoire, Bénédicte M.J. Merle, Christina Korb, Maja G. Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A. Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T.V.M. de Jong, Johannes R. Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertelsen, Norbert Pfeiffer, Astrid E. Fletcher, Paul J. Foster, Rufino Silva, Jean-François Korobelnik, Cécile Delcourt, Caroline C.W. Klaver, Soufiane Ajana, Blanca Arango-Gonzalez, Verena Arndt, Vaibhav Bhatia, Shomi S. Bhattacharya, Marc Biarnés, Anna Borrell, Sebastian Bühren, Sofia M. Calado, Johanna M. Colijn, Audrey Cougnard-Grégoire, Sascha Dammeier, Eiko K. de Jong, Berta De la Cerda, Cécile Delcourt, Anneke I. den Hollander, Francisco J. Diaz-Corrales, Sigrid Diether, Eszter Emri, Tanja Endermann, Lucia L. Ferraro, MÃriam Garcia, Thomas J. Heesterbeek, Sabina Honisch, Carel B. Hoyng, Eveline Kersten, Ellen Kilger, Caroline C.W. Klaver, Hanno Langen, Imre Lengyel, Phil Luthert, Cyrille Maugeais, Magda Meester-Smoor, Bénédicte M.J. Merle, Jordi Monés, Everson Nogoceke, Tunde Peto, Frances M. Pool, Eduardo RodrÃguez, Marius Ueffing, Karl U. Ulrich Bartz-Schmidt, Elisabeth M. van Leeuwen, Timo Verzijden, Markus Zumbansen, Niyazi Acar, Eleftherios Anastosopoulos, Augusto Azuara-Blanco, Arthur Bergen, Geir Bertelsen, Christine Binquet, Alan Bird, Lionel Brétillon, Alain Bron, Gabrielle Buitendijk, Maria Luz Cachulo, Usha Chakravarthy, Michelle Chan, Petrus Chang, Johanna Colijn, Audrey Cougnard-Grégoire, Catherine Creuzot-Garcher, Philippa Cumberland, José Cunha-Vaz, Vincent Daien, Gabor Deak, Cécile Delcourt, Marie-Noëlle Delyfer, Anneke den Hollander, Martha Dietzel, Maja Gran Erke, Sascha Fauser, Robert Finger, Astrid Fletcher, Paul Foster, Panayiota Founti, Arno Göbel, Theo Gorgels, Jakob Grauslund, Franz Grus, Christopher Hammond, Catherine Helmer, Hans-Werner Hense, Manuel Hermann, René Hoehn, Ruth Hogg, Frank Holz, Carel Hoyng, Nomdo Jansonius, Sarah Janssen, Anthony Khawaja, Caroline Klaver, Jean-François Korobelnik, Julia Lamparter, Mélanie Le Goff, Sergio Leal, Yara Lechanteur, Terho Lehtimäki, Andrew Lotery, Irene Leung, Matthias Mauschitz, Bénédicte Merle, Verena Meyer zu Westrup, Edoardo Midena, Stefania Miotto, Alireza Mirshahi, Sadek Mohan-Saïd, Michael Mueller, Alyson Muldrew, Sandrina Nunes, Konrad Oexle, Tunde Peto, Stefano Piermarocchi, Elena Prokofyeva, Jugnoo Rahi, Olli Raitakari, Luisa Ribeiro, Marie-Bénédicte Rougier, José Sahel, Aggeliki Salonikiou, Clarisa Sanchez, Steffen Schmitz-Valckenberg, Cédric Schweitzer, Tatiana Segato, Jasmin Shehata, Rufino Silva, Giuliana Silvestri, Christian Simader, Eric Souied, Henriet Springelkamp, Robyn Tapp, Fotis Topouzis, Virginie Verhoeven, Therese Von Hanno, Stela Vujosevic, Katie Williams, Christian Wolfram, Jennifer Yip, Jennyfer Zerbib, Isabella Zwiener Prevalence of Age-Related Macular Degeneration in Europe published pages: , ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2017.05.035 |
Ophthalmology | 2020-04-01 |
2017 |
Christina Kiel, Claire Lastrucci, Philip J. Luthert, Luis Serrano Simple and complex retinal dystrophies are associated with profoundly different disease networks published pages: 41835, ISSN: 2045-2322, DOI: 10.1038/srep41835 |
Scientific Reports 7 | 2020-04-01 |
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