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EYE-RISK SIGNED

Exploring the combined role of genetic and non-genetic factors for developing Age-Related Macular Degeneration: A systems level analysis of disease subgroups, risk factors, and pathways

Total Cost €

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EC-Contrib. €

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Partnership

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Project "EYE-RISK" data sheet

The following table provides information about the project.

Coordinator
EBERHARD KARLS UNIVERSITAET TUEBINGEN 

Organization address
address: GESCHWISTER-SCHOLL-PLATZ
city: TUEBINGEN
postcode: 72074
website: www.uni-tuebingen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.eyerisk.eu
 Total cost 6˙069˙996 €
 EC max contribution 5˙972˙496 € (98%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-PHC-2014-two-stage
 Funding Scheme RIA
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2019-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) coordinator 1˙360˙875.00
2    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 962˙250.00
3    AYOXXA BIOSYSTEMS GMBH DE (Cologne) participant 608˙500.00
4    THE QUEEN'S UNIVERSITY OF BELFAST UK (BELFAST) participant 592˙116.00
5    STICHTING KATHOLIEKE UNIVERSITEIT NL (NIJMEGEN) participant 539˙375.00
6    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 501˙992.00
7    UNIVERSITE DE BORDEAUX FR (BORDEAUX) participant 416˙875.00
8    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) participant 360˙000.00
9    FUNDACION BARCELONA MACULA FOUNDATION RESEARCH FOR VISION ES (BARCELONA) participant 320˙531.00
10    FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD ES (SEVILLA) participant 198˙607.00
11    PRO RETINA DEUTSCHLAND DE (AACHEN) participant 106˙250.00
12    UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE (DUBLIN) participant 5˙000.00
13    MOORFIELDS EYE HOSPITAL NHS FOUNDATION TRUST UK (LONDON) participant 124.00
14    F. HOFFMANN-LA ROCHE AG CH (BASEL) participant 0.00

Map

 Project objective

Age-related macular degeneration (AMD) is the world’s most important age-related blinding disorder. The current proposal utilises epidemiological data describing clinical phenotype, molecular genetics, lifestyle, nutrition, and in-depth retinal imaging derived from existing longitudinal European epidemiological cohorts and biobanks to provide three major insights needed for long-lasting prevention and therapy for AMD: (a) the development of robust algorithms utilising genetic and non-genetic risk factors to identify personalised risks of developing advanced wet and dry AMD; (b) the identification of novel biomarkers for further stratification of disease risks. New insights from (a)(b) will be used to elaborate preventive medical recommendations for highrisk subgroups of AMD patients; and (c) the identification of molecular drivers/biological pathways relevant for onset and progression of advanced AMD that will be used to identify and validate new therapeutic targets.

Key deliverables are: 1. Determination of AMD frequency in Europe, and assessment of AMD risk for phenotypical, genetic, environmental, and biochemical risk factors and their interaction. (WP1-3) 2. Development of a web-based prediction model for personalised risk assessment of AMD based on integration of risk profiles derived from retinal imaging, molecular genetics, assessment of lifestyle, and biochemical testing. (WP4) 3. Modelling and functional characterisation of pathophysiological pathways identified from integrated analysis of current knowledge and the above risk profiles. (WP5) 4. Experimental testing and interpretation of pathophysiological consequences of risks at the molecular level. (WP6) 5. An extension and refinement of the prediction model (WP4) based on work in WP5 and WP6 to generate clinical guidelines for the medical management of high-risk subgroups of patients with AMD. (WP7) 6. Promotion and dissemination of newly gained knowledge towards AMD prevention and therapy development

 Deliverables

List of deliverables.
Workshops Other 2020-04-01 17:16:16
EYE-RISK website Websites, patent fillings, videos etc. 2020-04-01 17:16:16
Dissemination Documents, reports 2020-04-01 17:16:16

Take a look to the deliverables list in detail:  detailed list of EYE-RISK deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Jordi Monés, Marc Biarnés
The Rate of Progression of Geographic Atrophy Decreases With Increasing Baseline Lesion Size Even After the Square Root Transformation
published pages: 40, ISSN: 2164-2591, DOI: 10.1167/tvst.7.6.40
Translational Vision Science & Technology 7/6 2020-04-01
2019 Eveline Kersten, Sascha Dammeier, Soufiane Ajana, Joannes M. M. Groenewoud, Marius Codrea, Franziska Klose, Yara T. Lechanteur, Sascha Fauser, Marius Ueffing, Cécile Delcourt, Carel B. Hoyng, Eiko K. de Jong, Anneke I. den Hollander
Metabolomics in serum of patients with non-advanced age-related macular degeneration reveals aberrations in the glutamine pathway
published pages: e0218457, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0218457
PLOS ONE 14/6 2020-04-01
2018 Eveline Kersten, Maartje J. Geerlings, Marc Pauper, Jordi Corominas, Bjorn Bakker, Lebriz Altay, Sascha Fauser, Eiko K. de Jong, Carel B. Hoyng, Anneke I. den Hollander
Genetic screening for macular dystrophies in patients clinically diagnosed with dry age‐related macular degeneration
published pages: 569-574, ISSN: 0009-9163, DOI: 10.1111/cge.13447
Clinical Genetics 94/6 2020-04-01
2018 Philip J. Luthert, Luis Serrano, Christina Kiel
Opportunities and Challenges of Whole-Cell and -Tissue Simulations of the Outer Retina in Health and Disease
published pages: 131-152, ISSN: 2574-3414, DOI: 10.1146/annurev-biodatasci-080917-013356
Annual Review of Biomedical Data Science 1/1 2020-04-01
2019 Thomas J. Heesterbeek, Eiko K. de Jong, Ilhan E. Acar, Joannes M. M. Groenewoud, Bart Liefers, Clara I. Sánchez, Tunde Peto, Carel B. Hoyng, Daniel Pauleikhoff, Hans W. Hense, Anneke I. den Hollander
Genetic risk score has added value over initial clinical grading stage in predicting disease progression in age-related macular degeneration
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-43144-3
Scientific Reports 9/1 2020-04-01
2019 Bénédicte M.J. Merle, Johanna M. Colijn, Audrey Cougnard-Grégoire, Alexandra P.M. de Koning-Backus, Marie-Noëlle Delyfer, Jessica C. Kiefte-de Jong, Magda Meester-Smoor, Catherine Féart, Timo Verzijden, Cécilia Samieri, Oscar H. Franco, Jean-François Korobelnik, Caroline C.W. Klaver, Cécile Delcourt, Soufiane Ajana, Blanca Arango-Gonzalez, Angela Armento, Verena Arndt, Vaibhav Bhatia, Shom
Mediterranean Diet and Incidence of Advanced Age-Related Macular Degeneration
published pages: 381-390, ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2018.08.006
Ophthalmology 126/3 2020-04-01
2018 Elisabeth M. van Leeuwen, Eszter Emri, Benedicte M.J. Merle, Johanna M. Colijn, Eveline Kersten, Audrey Cougnard-Gregoire, Sascha Dammeier, Magda Meester-Smoor, Frances M. Pool, Eiko K. de Jong, Cécile Delcourt, Eduardo Rodrigez-Bocanegra, Marc Biarnés, Philip J. Luthert, Marius Ueffing, Caroline C.W. Klaver, Everson Nogoceke, Anneke I. den Hollander, Imre Lengyel
A new perspective on lipid research in age-related macular degeneration
published pages: , ISSN: 1350-9462, DOI: 10.1016/j.preteyeres.2018.04.006
Progress in Retinal and Eye Research 2020-04-01
2017 Eveline Kersten, Maartje J. Geerlings, Anneke I. den Hollander, Eiko K. de Jong, Sascha Fauser, Tunde Peto, Carel B. Hoyng
Phenotype Characteristics of Patients With Age-Related Macular Degeneration Carrying a Rare Variant in the Complement Factor H Gene
published pages: 1037, ISSN: 2168-6165, DOI: 10.1001/jamaophthalmol.2017.3195
JAMA Ophthalmology 135/10 2020-04-01
2018 Geerlings, Maartje J.; Kersten, Eveline; Groenewoud, Joannes M.M.; Fritsche, Lars G.; Hoyng, Carel B.; de Jong, Eiko K.; den Hollander, Anneke I.
Geographic distribution of rare variants associated with age-related macular degeneration
published pages: 75-82, ISSN: 1090-0535, DOI:
Molecular Vision 24 2020-04-01
2018 Jordi Corominas, Johanna M. Colijn, Maartje J. Geerlings, Marc Pauper, Bjorn Bakker, Najaf Amin, Laura Lores Motta, Eveline Kersten, Alejandro Garanto, Joost A.M. Verlouw, Jeroen G.J. van Rooij, Robert Kraaij, Paulus T.V.M. de Jong, Albert Hofman, Johannes R. Vingerling, Tina Schick, Sascha Fauser, Eiko K. de Jong, Cornelia M. van Duijn, Carel B. Hoyng, Caroline C.W. Klaver, Anneke I. den Hollander
Whole-Exome Sequencing in Age-Related Macular Degeneration Identifies Rare Variants in COL8A1 , a Component of Bruch’s Membrane
published pages: , ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2018.03.040
Ophthalmology 2020-04-01
2017 Eveline Kersten, Constantin C. Paun, Rosa L. Schellevis, Carel. B. Hoyng, Cécile Delcourt, Imre Lengyel, Tunde Peto, Marius Ueffing, Caroline C.W. Klaver, Sascha Dammeier, Anneke I. den Hollander, Eiko K. de Jong
Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration
published pages: , ISSN: 0039-6257, DOI: 10.1016/j.survophthal.2017.05.003
Survey of Ophthalmology 2020-04-01
2017 Jordi Monés, Míriam Garcia, Marc Biarnés, Aparna Lakkaraju, Lucia Ferraro
Drusen Ooze: A Novel Hypothesis in Geographic Atrophy
published pages: , ISSN: 2468-6530, DOI: 10.1016/j.oret.2017.02.006
Ophthalmology Retina 2020-04-01
2017 Jordi Monés, Marc Biarnés
Geographic atrophy phenotype identification by cluster analysis
published pages: bjophthalmol-201, ISSN: 0007-1161, DOI: 10.1136/bjophthalmol-2017-310268
British Journal of Ophthalmology 2020-04-01
2017 Matthew G. Pilgrim, Imre Lengyel, Antonio Lanzirotti, Matt Newville, Sarah Fearn, Eszter Emri, Jonathan C. Knowles, Jeffrey D. Messinger, Russell W. Read, Clyde Guidry, Christine A. Curcio
Subretinal Pigment Epithelial Deposition of Drusen Components Including Hydroxyapatite in a Primary Cell Culture Model
published pages: 708, ISSN: 1552-5783, DOI: 10.1167/iovs.16-21060
Investigative Opthalmology & Visual Science 58/2 2020-04-01
2016 Elod Kortvely, Stefanie M. Hauck, Jennifer Behler, Nurulain Ho, Marius Ueffing
The unconventional secretion of ARMS2
published pages: ddw162, ISSN: 0964-6906, DOI: 10.1093/hmg/ddw162
Human Molecular Genetics 2020-04-01
2017 Johanna M. Colijn, Gabriëlle H.S. Buitendijk, Elena Prokofyeva, Dalila Alves, Maria L. Cachulo, Anthony P. Khawaja, Audrey Cougnard-Gregoire, Bénédicte M.J. Merle, Christina Korb, Maja G. Erke, Alain Bron, Eleftherios Anastasopoulos, Magda A. Meester-Smoor, Tatiana Segato, Stefano Piermarocchi, Paulus T.V.M. de Jong, Johannes R. Vingerling, Fotis Topouzis, Catherine Creuzot-Garcher, Geir Bertelsen, Norbert Pfeiffer, Astrid E. Fletcher, Paul J. Foster, Rufino Silva, Jean-François Korobelnik, Cécile Delcourt, Caroline C.W. Klaver, Soufiane Ajana, Blanca Arango-Gonzalez, Verena Arndt, Vaibhav Bhatia, Shomi S. Bhattacharya, Marc Biarnés, Anna Borrell, Sebastian Bühren, Sofia M. Calado, Johanna M. Colijn, Audrey Cougnard-Grégoire, Sascha Dammeier, Eiko K. de Jong, Berta De la Cerda, Cécile Delcourt, Anneke I. den Hollander, Francisco J. Diaz-Corrales, Sigrid Diether, Eszter Emri, Tanja Endermann, Lucia L. Ferraro, Míriam Garcia, Thomas J. Heesterbeek, Sabina Honisch, Carel B. Hoyng, Eveline Kersten, Ellen Kilger, Caroline C.W. Klaver, Hanno Langen, Imre Lengyel, Phil Luthert, Cyrille Maugeais, Magda Meester-Smoor, Bénédicte M.J. Merle, Jordi Monés, Everson Nogoceke, Tunde Peto, Frances M. Pool, Eduardo Rodríguez, Marius Ueffing, Karl U. Ulrich Bartz-Schmidt, Elisabeth M. van Leeuwen, Timo Verzijden, Markus Zumbansen, Niyazi Acar, Eleftherios Anastosopoulos, Augusto Azuara-Blanco, Arthur Bergen, Geir Bertelsen, Christine Binquet, Alan Bird, Lionel Brétillon, Alain Bron, Gabrielle Buitendijk, Maria Luz Cachulo, Usha Chakravarthy, Michelle Chan, Petrus Chang, Johanna Colijn, Audrey Cougnard-Grégoire, Catherine Creuzot-Garcher, Philippa Cumberland, José Cunha-Vaz, Vincent Daien, Gabor Deak, Cécile Delcourt, Marie-Noëlle Delyfer, Anneke den Hollander, Martha Dietzel, Maja Gran Erke, Sascha Fauser, Robert Finger, Astrid Fletcher, Paul Foster, Panayiota Founti, Arno Göbel, Theo Gorgels, Jakob Grauslund, Franz Grus, Christopher Hammond, Catherine Helmer, Hans-Werner Hense, Manuel Hermann, René Hoehn, Ruth Hogg, Frank Holz, Carel Hoyng, Nomdo Jansonius, Sarah Janssen, Anthony Khawaja, Caroline Klaver, Jean-François Korobelnik, Julia Lamparter, Mélanie Le Goff, Sergio Leal, Yara Lechanteur, Terho Lehtimäki, Andrew Lotery, Irene Leung, Matthias Mauschitz, Bénédicte Merle, Verena Meyer zu Westrup, Edoardo Midena, Stefania Miotto, Alireza Mirshahi, Sadek Mohan-Saïd, Michael Mueller, Alyson Muldrew, Sandrina Nunes, Konrad Oexle, Tunde Peto, Stefano Piermarocchi, Elena Prokofyeva, Jugnoo Rahi, Olli Raitakari, Luisa Ribeiro, Marie-Bénédicte Rougier, José Sahel, Aggeliki Salonikiou, Clarisa Sanchez, Steffen Schmitz-Valckenberg, Cédric Schweitzer, Tatiana Segato, Jasmin Shehata, Rufino Silva, Giuliana Silvestri, Christian Simader, Eric Souied, Henriet Springelkamp, Robyn Tapp, Fotis Topouzis, Virginie Verhoeven, Therese Von Hanno, Stela Vujosevic, Katie Williams, Christian Wolfram, Jennifer Yip, Jennyfer Zerbib, Isabella Zwiener
Prevalence of Age-Related Macular Degeneration in Europe
published pages: , ISSN: 0161-6420, DOI: 10.1016/j.ophtha.2017.05.035
Ophthalmology 2020-04-01
2017 Christina Kiel, Claire Lastrucci, Philip J. Luthert, Luis Serrano
Simple and complex retinal dystrophies are associated with profoundly different disease networks
published pages: 41835, ISSN: 2045-2322, DOI: 10.1038/srep41835
Scientific Reports 7 2020-04-01

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