Opendata, web and dolomites

DECISION SIGNED

DECOMPENSATED CIRRHOSIS: IDENTIFICATION OF NEW COMBINATORIAL THERAPIES BASED ON SYSTEMS APPROACHES

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DECISION project word cloud

Explore the words cloud of the DECISION project. It provides you a very rough idea of what is the project "DECISION" about.

optimized    events    betablockers    first    underlying    integrating    proton    200    despite    decrease    pathophysiology    laxatives    ascites    standard    diuretics    time    pump    mainly    risk    therapies    inhibitors    28    steroids    treatment    models    worldwide    interindividual    antibiotics    combinatorial    agents    refine    biological    statins    precipitating    acute    600    cirrhosis    samples    animal    omic    clinical    trial    progression    predicting    day    multiple    variability    decision    death    million    receive    15    chronic    treatments    therapy    vasoconstrictors    patients    mechanisms    absorbable    profiling    personalization    outcome    presentation    hemorrhage    responsible    intravenous    antiviral    2013    liver    combination    albumin    standardized    gastrointestinal    prevent    decompensation    aclf    oral    calls    throughput    data    hepatic    deaths    encephalopathy    decompensated    points    tests    anticoagulants    mortality    prognostic    heterogeneity   

Project "DECISION" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) 

Organization address
address: TRAVESSERA DE GRACIA 11, 7TH FLOOR
city: BARCELONA
postcode: 8021
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 6˙000˙007 €
 EC max contribution 6˙000˙000 € (100%)
 Programme 1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
 Code Call H2020-SC1-2019-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-04-01   to  2025-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN FOUNDATION FOR THE STUDY OF CHRONIC LIVER FAILURE (EF-CLIF) ES (BARCELONA) coordinator 1˙008˙650.00
2    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) participant 620˙500.00
3    Concentris Research Management GmbH DE (Fürstenfeldbruck) participant 488˙500.00
4    ASSISTANCE PUBLIQUE HOPITAUX DE PARIS FR (PARIS) participant 445˙472.00
5    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 404˙222.00
6    FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA ES (BARCELONA) participant 396˙722.00
7    FUNDACION PUBLICA MIGUEL SERVET ES (PAMPLONA) participant 382˙500.00
8    COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES FR (PARIS 15) participant 345˙000.00
9    UNIVERSITAETSKLINIKUM AACHEN DE (AACHEN) participant 300˙874.00
10    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) participant 300˙000.00
11    YH YOUHEALTH AB SE (STOCKHOLM) participant 260˙000.00
12    ALMA MATER STUDIORUM - UNIVERSITA DI BOLOGNA IT (BOLOGNA) participant 196˙722.00
13    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 130˙879.00
14    INSTITUT CATALA DE LA SALUT ES (BARCELONA) participant 130˙472.00
15    SERVICIO MADRILENO DE SALUD ES (MADRID) participant 130˙472.00
16    UNIVERSITA DEGLI STUDI DI TORINO IT (TORINO) participant 130˙472.00
17    UNIVERSITAT DE BARCELONA ES (BARCELONA) participant 120˙000.00
18    NORDIC BIOSCIENCE A/S DK (HERLEV) participant 66˙043.00
19    EUROPEAN ASSOCIATION FOR THE STUDYOF THE LIVER CH (ZURICH) participant 50˙000.00
20    EUROPEAN LIVER PATIENTS ASSOCIATION BE (BRUXELLES) participant 50˙000.00
21    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) participant 42˙500.00

Map

 Project objective

In 2013, cirrhosis was responsible for 1.2 million deaths worldwide. This mortality is mainly due to cirrhosis decompensation, i.e. development of ascites, hepatic encephalopathy, and/or gastrointestinal hemorrhage, and its progression to acute-on-chronic liver failure (ACLF). Patients with decompensated cirrhosis receive many treatments such as intravenous and oral absorbable antibiotics, oral non-absorbable antibiotics, albumin, proton-pump inhibitors, laxatives, diuretics, betablockers, vasoconstrictors, statins, anticoagulants, steroids and antiviral agents. Despite these multiple treatments, ACLF or mortality in patients with decompensation of cirrhosis remains high (15% at day 28, 28% at day 90) because of large interindividual variability in precipitating events, in clinical presentation and in response to treatment. This heterogeneity calls for treatment personalization according to underlying mechanisms. The objective of DECISION is to enhance our understanding, at systems level, of the pathophysiology of decompensation of cirrhosis leading to ACLF or death to decrease patients’ mortality at day 28. First, DECISION will improve our knowledge of the pathophysiology of decompensation of cirrhosis by integrating results of high-throughput multi-omic profiling with comprehensive clinical data from 2,200 fully characterized patients (more than 8,600 time points) with available standardized biological samples. Second, we will identify novel combinatorial therapies for patients with decompensation of cirrhosis to prevent death. We will refine these therapies in new and/or optimized animal models and then test the best combination in high risk patients in a phase II clinical trial built in DECISION. Third, we will develop 2 tests: one predicting outcome of patients with decompensation of cirrhosis when treated with standard treatment (prognostic test); and the other identifying patients who will respond to the novel combinatorial therapy (test for response).

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The information about "DECISION" are provided by the European Opendata Portal: CORDIS opendata.

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