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CoMorMent SIGNED

Predicting comorbid cardiovascular disease in individuals with mental disorder by decoding disease mechanisms

Total Cost €

EC-Contrib. €

Partnership

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CoMorMent project word cloud

Explore the words cloud of the CoMorMent project. It provides you a very rough idea of what is the project "CoMorMent" about.

genes brain national remediate combination science gene smoking comorbidity computation registries disease functional multidisciplinary mri data diseases million samples basis composition mediated biobank exercise stratification considerable cardiovascular variation poses statistical genetics diet genetic clinical molecular expert tools mental sequence validated financial severe team structural care lifestyles genotyped builds unhealthy advantage prediction variants expression psychiatry epidemiology tested fat incidence learning accompanying conferring precision machine underlying big public experts body cardiology uncover medicine comorment trajectories risk combined discover comorbid neuroscience lifestyle united expressed health disorders mechanisms form burden issue people generate

Project "CoMorMent" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Norway [NO]
Total cost	5˙998˙613 €
EC max contribution	5˙998˙613 € (100%)
Programme	1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2023-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	coordinator	1˙523˙625.00
2	ISLENSK ERFDAGREINING EHF ISLENSK ERFDAGREINING EHF Organization address address: STURLUGOTU 8 city: REYKJAVIK postcode: 101 website: www.decode.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IS (REYKJAVIK)	participant	818˙750.00
3	REGION HOVEDSTADEN REGION HOVEDSTADEN Organization address address: KONGENS VAENGE 2 city: HILLEROD postcode: 3400 website: www.regionh.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HILLEROD)	participant	769˙250.00
4	KAROLINSKA INSTITUTET KAROLINSKA INSTITUTET Organization address address: Nobels Vag 5 city: STOCKHOLM postcode: 17177 website: www.ki.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	667˙800.00
5	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	553˙125.00
6	THE UNIVERSITY OF EDINBURGH THE UNIVERSITY OF EDINBURGH Organization address address: OLD COLLEGE, SOUTH BRIDGE city: EDINBURGH postcode: EH8 9YL website: www.ed.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (EDINBURGH)	participant	532˙756.00
7	MULTIMODAL IMAGING SERVICES CORPORATION MULTIMODAL IMAGING SERVICES CORPORATION Organization address address: 4747 EXECUTIVE DRIVE SUITE 820 city: SAN DIEGO CA postcode: 92121 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	US (SAN DIEGO CA)	participant	451˙875.00
8	AMRA MEDICAL AB AMRA MEDICAL AB Organization address address: BADHUSGATAN 5 city: LINKOPING postcode: 582 22 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (LINKOPING)	participant	360˙000.00
9	HASKOLI ISLANDS HASKOLI ISLANDS Organization address address: SAEMUNDARGOTU 2 city: REYKJAVIK postcode: 101 website: www.hi.is contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IS (REYKJAVIK)	participant	321˙432.00

Map

Project objective

Comorbid cardiovascular disease in people with severe mental disorders is a major public health concern and poses a considerable financial burden on European Health Care. The CoMorMent project will uncover mechanisms underlying the higher incidence of cardiovascular disease in people with mental disorders. This project builds on our recent findings that genetic variation that affects genes expressed in the brain and which increase the risk of mental disorders also impact lifestyle and behaviour (e.g. diet, exercise, and smoking) that increase cardiovascular risk. The project will identify molecular mechanisms common to mental disorders and unhealthy lifestyles that increase the risk of cardiovascular disease. We will take advantage of our genotyped biobank samples united with large national registries with information about disease trajectories and comorbidity in over 1.8 million people. The “big data” available to CoMorMent means that we can apply new statistical tools to discover novel sequence variants conferring risk of both mental disorders and cardiovascular diseases and determine how these may be mediated by lifestyle or behaviour. We will characterize the underlying mechanisms by identifying accompanying structural brain changes and body fat composition from MRI data in combination with gene expression and functional studies. The CoMorMent multidisciplinary expert team in clinical science (cardiology, psychiatry), genetic epidemiology, molecular genetics, and neuroscience combined with experts in machine learning and computation will generate findings that will form the basis of novel stratification and prediction tools, which will be tested and validated in clinical samples. Thus, CoMorMent will form the basis for a new approach in clinical studies by providing precision medicine tools for clinical implementation to remediate a major public health issue.

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The information about "COMORMENT" are provided by the European Opendata Portal: CORDIS opendata.