Opendata, web and dolomites

PRISM SIGNED

Ice-binding proteins: from antifreeze mechanism to resistant soft materials

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PRISM project word cloud

Explore the words cloud of the PRISM project. It provides you a very rough idea of what is the project "PRISM" about.

plays    strategy    affinity    bound    point    seas    cryopreservation    guide    experiments    thermal    water    synthetic    agrifood    adsorption    supercooling    narrow    fish    assembly    molecule    covalent    tackle    avenues    sensitive    ice    polar    block    unusual    nascent    colligative    temperature    tolerant    unravel    stability    fundamental    depression    visualize    interfaces    coping    encoding    dispersion    solution    insights    crystalline    crystallization    survival    templating    biomedicine    crop    macromolecular    organisms    antifreeze    explore    agents    hysteresis    freeze    science    strategies    coatings    living    lethal    routes    foreign    powerful    single    progress    efficient    molecular    preparation    proteins    environments    first    materials    polymers    hardiness    crystals    freezing    decisive    detrimental    soft    strength    record    resistant    binding    antifreezes    superior    interaction    extreme    profound    gap    promise    holds    mechanism   

Project "PRISM" data sheet

The following table provides information about the project.

Coordinator
TECHNISCHE UNIVERSITEIT EINDHOVEN 

Organization address
address: GROENE LOPER 3
city: EINDHOVEN
postcode: 5612 AE
website: www.tue.nl/en

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.voetslab.nl
 Total cost 1˙661˙605 €
 EC max contribution 1˙661˙605 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TECHNISCHE UNIVERSITEIT EINDHOVEN NL (EINDHOVEN) coordinator 1˙661˙605.00

Map

 Project objective

Crystallization of water into ice is lethal to most organisms and detrimental to many soft materials. Freeze-tolerant fish living in polar seas evolved to tackle this problem with an unusual coping strategy. They produce ‘antifreeze’ proteins that block the growth of nascent ice crystals within a narrow temperature range known as the ‘thermal hysteresis gap’ enabling survival under extreme conditions. Encoding this functionality into synthetic polymers would open up new avenues in biomedicine, agrifood and materials science for e.g. cryopreservation, crop hardiness, ice-templating, dispersion stability, and advanced coatings. Progress requires a profound understanding of the mechanism of non-colligative freezing point depression at the molecular level and allows for efficient strategies for the design and preparation of powerful macromolecular antifreezes.

I propose to unravel how antifreeze proteins work and to build upon these insights to explore effective routes towards ice-binding polymers aiming to make sensitive soft materials freeze-resistant. Within this challenge we first focus on single-molecule experiments to visualize bound proteins and study the strength of the non-covalent interaction with ice. We will study if and when adsorption on ‘foreign’ interfaces and solution assembly impact activity. These fundamental insights will guide our research towards synthetic antifreeze agents with superior functionality to achieve record supercooling in complex environments. This knowledge-based design of polymers with high affinity for crystalline interfaces holds great promise for many areas of science and technology in which crystallization plays a decisive role.

 Publications

year authors and title journal last update
List of publications.
2018 Christian C. M. Sproncken, Romà Surís-Valls, Hande E. Cingil, Christophe Detrembleur, Ilja K. Voets
Complex Coacervate Core Micelles Containing Poly(vinyl alcohol) Inhibit Ice Recrystallization
published pages: 1700814, ISSN: 1022-1336, DOI: 10.1002/marc.201700814
Macromolecular Rapid Communications 39/17 2020-04-22
2017 Anneloes S. Oude Vrielink, Tyler D. R. Vance, Arthur M. de Jong, Peter L. Davies, Ilja K. Voets
Unusually high mechanical stability of bacterial adhesin extender domains having calcium clamps
published pages: e0174682, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0174682
PLOS ONE 12/4 2020-04-22
2018 Z. Faidon Brotzakis, Ilja K. Voets, Huib J. Bakker, Peter G. Bolhuis
Water structure and dynamics in the hydration layer of a type III anti-freeze protein
published pages: 6996-7006, ISSN: 1463-9076, DOI: 10.1039/c8cp00170g
Physical Chemistry Chemical Physics 20/10 2020-04-22
2017 Qing Ke, Yong-Yeol Ahn, Cassidy R. Sugimoto
A systematic identification and analysis of scientists on Twitter
published pages: e0175368, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0175368
PLOS ONE 12/4 2020-04-22
2017 I. K. Voets
From ice-binding proteins to bio-inspired antifreeze materials
published pages: 4808-4823, ISSN: 1744-683X, DOI: 10.1039/C6SM02867E
Soft Matter 13/28 2020-04-22
2016 Anneloes S. Oude Vrielink, Antonio Aloi, Luuk L. C. Olijve, Ilja K. Voets
Interaction of ice binding proteins with ice, water and ions
published pages: 18906, ISSN: 1559-4106, DOI: 10.1116/1.4939462
Biointerphases 11/1 2020-04-22
2017 Z. Faidon Brotzakis, Mascha Gehre, Ilja K. Voets, Peter G. Bolhuis
Stability and growth mechanism of self-assembling putative antifreeze cyclic peptides
published pages: 19032-19042, ISSN: 1463-9076, DOI: 10.1039/C7CP02465G
Physical Chemistry Chemical Physics 19/29 2020-04-22
2016 Luuk L. C. Olijve, Konrad Meister, Arthur L. DeVries, John G. Duman, Shuaiqi Guo, Huib J. Bakker, Ilja K. Voets
Blocking rapid ice crystal growth through nonbasal plane adsorption of antifreeze proteins
published pages: 3740-3745, ISSN: 0027-8424, DOI: 10.1073/pnas.1524109113
Proceedings of the National Academy of Sciences 113/14 2020-04-22
2017 Shuaiqi Guo, Corey A. Stevens, Tyler D. R. Vance, Luuk L. C. Olijve, Laurie A. Graham, Robert L. Campbell, Saeed R. Yazdi, Carlos Escobedo, Maya Bar-Dolev, Victor Yashunsky, Ido Braslavsky, David N. Langelaan, Steven P. Smith, John S. Allingham, Ilja K. Voets, Peter L. Davies
Structure of a 1.5-MDa adhesin that binds its Antarctic bacterium to diatoms and ice
published pages: e1701440, ISSN: 2375-2548, DOI: 10.1126/sciadv.1701440
Science Advances 3/8 2020-04-22
2016 Luuk L. C. Olijve, Anneloes S. Oude Vrielink, Ilja K. Voets
A Simple and Quantitative Method to Evaluate Ice Recrystallization Kinetics Using the Circle Hough Transform Algorithm
published pages: 4190-4195, ISSN: 1528-7483, DOI: 10.1021/acs.cgd.5b01637
Crystal Growth & Design 16/8 2020-04-22
2016 Luuk L. C. Olijve, Marco M. R. M. Hendrix, Ilja K. Voets
Influence of Polymer Chain Architecture of Poly(vinyl alcohol) on the Inhibition of Ice Recrystallization
published pages: 951-958, ISSN: 1022-1352, DOI: 10.1002/macp.201500497
Macromolecular Chemistry and Physics 217/8 2020-04-22
2016 Antonio Aloi, Clément Guibert, Luuk L.C. Olijve, Ilja K. Voets
Morphological evolution of complex coacervate core micelles revealed by iPAINT microscopy
published pages: 450-455, ISSN: 0032-3861, DOI: 10.1016/j.polymer.2016.08.002
Polymer 107 2020-04-22

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PRISM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PRISM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

FICOMOL (2019)

Field Control of Cold Molecular Collisions

Read More  

Photopharm (2020)

Photopharmacology: From Academia toward the Clinic.

Read More  

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More