Explore the words cloud of the FlyContext project. It provides you a very rough idea of what is the project "FlyContext" about.
The following table provides information about the project.
TECHNISCHE UNIVERSITAET MUENCHEN
|Coordinator Country||Germany [DE]|
|Total cost||1˙497˙600 €|
|EC max contribution||1˙497˙600 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-07-01 to 2021-06-30|
Take a look of project's partnership.
|1||TECHNISCHE UNIVERSITAET MUENCHEN||DE (MUENCHEN)||coordinator||1˙115˙199.00|
|2||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (MUENCHEN)||participant||382˙400.00|
How do we decide what to choose? While certain cues are preferred, others are avoided. But even innate preferences and aversions must be evaluated in a context-dependent manner. These contexts are environmental cues, but also internal state. In this proposal, I will address how the nervous system integrates chemosensory information with internal state to produce appropriate behaviors. I will present a research program relying on fly genetics, behavior analysis, and in vivo physiology to characterize the neural circuits and mechanisms involved in context-dependent processing of sensory cues. Specifically, I will address how three different internal states (hunger, mating state, sickness) change the perception and processing of odors and tastes. Together with my lab, I have previously demonstrated that the innately aversive odor CO2 is processed in a metabolic state-dependent manner in the fly brain. Exclusively in the context of hunger, CO2 aversion depends on a pathway that involves the mushroom body, a higher brain structure required for learning and memory in the fly. In objective 1, based on two prior behavioral screens, we will analyze the role of additional brain centers such as the lateral horn and the superior lateral protocerebrum in hunger-dependent processing of CO2 and the appetitive odor vinegar. In objective 2, we will dissect the neural underpinnings of polyamine perception. These molecules are indicators of protein breakdown that flies use in a mating state-dependent manner as cues for egg laying or foraging. Objective 3 will focus on the largely unexplored question of how infectious disease and subsequent immune reaction alters chemosensory choice behavior. Results of this proposal will establish a causal link between internal state-dependent chemosensory behavior and neural processing. Ultimately, understanding fundamental rules of context-dependent processing in the fly will provide an important framework for understanding human choice behavior.
|year||authors and title||journal||last update|
Juhi Sardana, Cristina Organisti, Ilona C. Grunwald Kadow
Eph Receptor Effector Ephexin Mediates Olfactory Dendrite Targeting in Drosophila
published pages: 873-888, ISSN: 1932-8451, DOI: 10.1002/dneu.22624
|Developmental Neurobiology 78/9||2019-09-09|
Sercan Sayin, Ariane C. Boehm, Johanna M. Kobler, Jean-FranÃ§ois De Backer, Ilona C. Grunwald Kadow
Internal State Dependent Odor Processing and Perceptionâ€”The Role of Neuromodulation in the Fly Olfactory System
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2018.00011
|Frontiers in Cellular Neuroscience 12||2019-09-09|
Sercan Sayin, Jean-Francois De Backer, K.P. Siju, Marina E. Wosniack, Laurence P. Lewis, Lisa-Marie Frisch, Benedikt Gansen, Philipp Schlegel, Amelia Edmondson-Stait, Nadiya Sharifi, Corey B. Fisher, Steven A. Calle-Schuler, J. Scott Lauritzen, Davi D. Bock, Marta Costa, Gregory S.X.E. Jefferis, Julijana Gjorgjieva, Ilona C. Grunwald Kadow
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.028
Ilona C Grunwald Kadow
State-dependent plasticity of innate behavior in fruit flies
published pages: 60-65, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.08.014
|Current Opinion in Neurobiology 54||2019-09-09|
Ashiq Hussain, Mo Zhang, Habibe K. ÃœÃ§punar, Thomas Svensson, Elsa Quillery, Nicolas Gompel, Rickard Ignell, Ilona C. Grunwald Kadow
Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines
published pages: e1002454, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.1002454
|PLOS Biology 14/5||2019-06-05|
Ashiq Hussain, Habibe K. ÃœÃ§punar, Mo Zhang, Laura F. Loschek, Ilona C. Grunwald Kadow
Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila
published pages: e1002455, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.1002455
|PLOS Biology 14/5||2019-06-05|
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The information about "FLYCONTEXT" are provided by the European Opendata Portal: CORDIS opendata.
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