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FlyContext SIGNED

Neural processing of context-dependent innate behavior

Total Cost €


EC-Contrib. €






 FlyContext project word cloud

Explore the words cloud of the FlyContext project. It provides you a very rough idea of what is the project "FlyContext" about.

framework    learning    memory    alters    choose    centers    molecules    laying    additional    structure    mechanisms    protocerebrum    polyamine    immune    relying    fundamental    rules    analyze    environmental    body    causal    underpinnings    appetitive    link    decide    cues    contexts    fly    unexplored    infectious    nervous    vivo    odor    indicators    chemosensory    question    superior    hunger    flies    aversions    circuits    how    preferences    sensory    sickness    disease    metabolic    breakdown    physiology    dissect    vinegar    perception    internal    innate    co2    behaviors    human    aversion    certain    behavior    integrates    preferred    context    manner    prior    ultimately    largely    depends    innately    lab    processed    aversive    subsequent    screens    demonstrated    dependent    neural    behavioral    brain    egg    odors    horn    mushroom    previously    appropriate    foraging    protein    reaction    tastes    lateral    exclusively    mating    genetics   

Project "FlyContext" data sheet

The following table provides information about the project.


Organization address
address: Arcisstrasse 21
postcode: 80333

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 1˙497˙600 €
 EC max contribution 1˙497˙600 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2021-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

How do we decide what to choose? While certain cues are preferred, others are avoided. But even innate preferences and aversions must be evaluated in a context-dependent manner. These contexts are environmental cues, but also internal state. In this proposal, I will address how the nervous system integrates chemosensory information with internal state to produce appropriate behaviors. I will present a research program relying on fly genetics, behavior analysis, and in vivo physiology to characterize the neural circuits and mechanisms involved in context-dependent processing of sensory cues. Specifically, I will address how three different internal states (hunger, mating state, sickness) change the perception and processing of odors and tastes. Together with my lab, I have previously demonstrated that the innately aversive odor CO2 is processed in a metabolic state-dependent manner in the fly brain. Exclusively in the context of hunger, CO2 aversion depends on a pathway that involves the mushroom body, a higher brain structure required for learning and memory in the fly. In objective 1, based on two prior behavioral screens, we will analyze the role of additional brain centers such as the lateral horn and the superior lateral protocerebrum in hunger-dependent processing of CO2 and the appetitive odor vinegar. In objective 2, we will dissect the neural underpinnings of polyamine perception. These molecules are indicators of protein breakdown that flies use in a mating state-dependent manner as cues for egg laying or foraging. Objective 3 will focus on the largely unexplored question of how infectious disease and subsequent immune reaction alters chemosensory choice behavior. Results of this proposal will establish a causal link between internal state-dependent chemosensory behavior and neural processing. Ultimately, understanding fundamental rules of context-dependent processing in the fly will provide an important framework for understanding human choice behavior.


year authors and title journal last update
List of publications.
2018 Juhi Sardana, Cristina Organisti, Ilona C. Grunwald Kadow
Eph Receptor Effector Ephexin Mediates Olfactory Dendrite Targeting in Drosophila
published pages: 873-888, ISSN: 1932-8451, DOI: 10.1002/dneu.22624
Developmental Neurobiology 78/9 2019-09-09
2018 Sercan Sayin, Ariane C. Boehm, Johanna M. Kobler, Jean-François De Backer, Ilona C. Grunwald Kadow
Internal State Dependent Odor Processing and Perception—The Role of Neuromodulation in the Fly Olfactory System
published pages: , ISSN: 1662-5102, DOI: 10.3389/fncel.2018.00011
Frontiers in Cellular Neuroscience 12 2019-09-09
2019 Sercan Sayin, Jean-Francois De Backer, K.P. Siju, Marina E. Wosniack, Laurence P. Lewis, Lisa-Marie Frisch, Benedikt Gansen, Philipp Schlegel, Amelia Edmondson-Stait, Nadiya Sharifi, Corey B. Fisher, Steven A. Calle-Schuler, J. Scott Lauritzen, Davi D. Bock, Marta Costa, Gregory S.X.E. Jefferis, Julijana Gjorgjieva, Ilona C. Grunwald Kadow
A Neural Circuit Arbitrates between Persistence and Withdrawal in Hungry Drosophila
published pages: , ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.028
Neuron 2019-09-09
2019 Ilona C Grunwald Kadow
State-dependent plasticity of innate behavior in fruit flies
published pages: 60-65, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.08.014
Current Opinion in Neurobiology 54 2019-09-09
2016 Ashiq Hussain, Mo Zhang, Habibe K. Üçpunar, Thomas Svensson, Elsa Quillery, Nicolas Gompel, Rickard Ignell, Ilona C. Grunwald Kadow
Ionotropic Chemosensory Receptors Mediate the Taste and Smell of Polyamines
published pages: e1002454, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.1002454
PLOS Biology 14/5 2019-06-05
2016 Ashiq Hussain, Habibe K. Üçpunar, Mo Zhang, Laura F. Loschek, Ilona C. Grunwald Kadow
Neuropeptides Modulate Female Chemosensory Processing upon Mating in Drosophila
published pages: e1002455, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.1002455
PLOS Biology 14/5 2019-06-05

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