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Autonomous Cellular Computers for Diagnosis

Total Cost €


EC-Contrib. €






 COMPUCELL project word cloud

Explore the words cloud of the COMPUCELL project. It provides you a very rough idea of what is the project "COMPUCELL" about.

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Project "COMPUCELL" data sheet

The following table provides information about the project.


Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for multiplexed diagnosis using the non-pathogenic bacterium Bacillus subtilis.

In a first research line, I will conceive a scalable detection machinery by engineering chimeric receptors detecting extracellular biomarkers via sensing domains derived from antibodies. In a second research line, I will implement bio-molecular computing systems operating within and across bacterial cells to perform multiplexed biomarkers analysis. I will deploy in B. subtilis biomolecular logic gates and will engineer specific cell-cell communication systems to perform distributed multicellular computation in a bacterial consortia.

My project is highly interdisciplinary and is at the cross-roads of genetic engineering, structural biology, biophysics, modeling, and clinics. On foundational point of view, I will make several breakthrough contributions to synthetic biology: (i) Advancing engineering frameworks for the Gram-positive model, B. subtilis. (ii) Pushing the limits of custom-ligand detection by engineered cells (iii) Exploring the frontiers of man-made biological computers. On an applied point of view, I plan to deliver a first prototype for the urinary diagnostic of diabetic nephropathy, a major complication of diabetes. Because of the modular design principles applied, my sensing platform will be reusable to diagnose other pathologies as well as for applications requiring custom-detection and bio-molecular computation like targeted therapy, drug delivery, or environmental monitoring.


year authors and title journal last update
List of publications.
2017 Hung-Ju Chang, Pauline Mayonove, Agustin Zavala, Angelique De Visch, Philippe Minard, Martin Cohen-Gonsaud, Jerome Bonnet
A Modular Receptor Platform To Expand the Sensing Repertoire of Bacteria
published pages: 166-175, ISSN: 2161-5063, DOI: 10.1021/acssynbio.7b00266
ACS Synthetic Biology 7/1 2020-03-20
2017 Hung-Ju Chang, Peter L. Voyvodic, Ana Zúñiga, Jérôme Bonnet
Microbially derived biosensors for diagnosis, monitoring and epidemiology
published pages: 1031-1035, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12791
Microbial Biotechnology 10/5 2020-03-20
2016 Sarah Guiziou, Vincent Sauveplane, Hung-Ju Chang, Caroline Clerté, Nathalie Declerck, Matthieu Jules, Jerome Bonnet
A part toolbox to tune genetic expression in Bacillus subtilis
published pages: gkw624, ISSN: 0305-1048, DOI: 10.1093/nar/gkw624
Nucleic Acids Research 2020-03-20
2018 Sarah Guiziou, Federico Ulliana, Violaine Moreau, Michel Leclere, Jerome Bonnet
An Automated Design Framework for Multicellular Recombinase Logic
published pages: 1406-1412, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00016
ACS Synthetic Biology 7/5 2020-03-20

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The information about "COMPUCELL" are provided by the European Opendata Portal: CORDIS opendata.

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