Opendata, web and dolomites

COMPUCELL SIGNED

Autonomous Cellular Computers for Diagnosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 COMPUCELL project word cloud

Explore the words cloud of the COMPUCELL project. It provides you a very rough idea of what is the project "COMPUCELL" about.

model    monitoring    biosensors    gates    view    diagnose    chimeric    structural    sensing    multicellular    therapy    advancing    modular    logic    bacillus    detect    line    bio    biological    antibodies    custom    detection    autonomous    multiple    engineer    principles    presenting    cells    subtilis    domains    engineering    platform    diabetes    limits    biology    computation    early    contributions    modeling    machinery    molecular    foundational    receptors    complicated    environmental    cross    man    detecting    gram    reusable    signals    extracellular    computers    diagnostic    multiplexed    diagnostics    diabetic    rational    diagnosis    frameworks    expertise    prototype    cell    nephropathy    drug    pathogenic    ligand    expensive    roads    interdisciplinary    deploy    genetic    communication    complication    frontiers    technologies    parallel    urinary    conceive    clinics    perform    attractive    plan    first    computing    living    breakthrough    replicate    affordable    diseases    synthetic    pushing    made    engineered    self    biophysics    positive    exploring    biomolecular    point    biomarkers    scalable    requiring    bacterial    distributed    bacterium    pathologies   

Project "COMPUCELL" data sheet

The following table provides information about the project.

Coordinator
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 

Organization address
address: RUE DE TOLBIAC 101
city: PARIS
postcode: 75654
website: www.inserm.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

Early diagnostics based on multiple biomarkers is key in numerous diseases, yet current technologies for multiplexed detection are complicated and expensive. Living cells detect and process various environmental signals in parallel and can self-replicate, presenting an attractive platform for scalable and affordable autonomous diagnostic devices. In this project, I will apply my expertise in synthetic biology, the rational engineering of biological systems, to build cell-based biosensors for multiplexed diagnosis using the non-pathogenic bacterium Bacillus subtilis.

In a first research line, I will conceive a scalable detection machinery by engineering chimeric receptors detecting extracellular biomarkers via sensing domains derived from antibodies. In a second research line, I will implement bio-molecular computing systems operating within and across bacterial cells to perform multiplexed biomarkers analysis. I will deploy in B. subtilis biomolecular logic gates and will engineer specific cell-cell communication systems to perform distributed multicellular computation in a bacterial consortia.

My project is highly interdisciplinary and is at the cross-roads of genetic engineering, structural biology, biophysics, modeling, and clinics. On foundational point of view, I will make several breakthrough contributions to synthetic biology: (i) Advancing engineering frameworks for the Gram-positive model, B. subtilis. (ii) Pushing the limits of custom-ligand detection by engineered cells (iii) Exploring the frontiers of man-made biological computers. On an applied point of view, I plan to deliver a first prototype for the urinary diagnostic of diabetic nephropathy, a major complication of diabetes. Because of the modular design principles applied, my sensing platform will be reusable to diagnose other pathologies as well as for applications requiring custom-detection and bio-molecular computation like targeted therapy, drug delivery, or environmental monitoring.

 Publications

year authors and title journal last update
List of publications.
2017 Hung-Ju Chang, Pauline Mayonove, Agustin Zavala, Angelique De Visch, Philippe Minard, Martin Cohen-Gonsaud, Jerome Bonnet
A Modular Receptor Platform To Expand the Sensing Repertoire of Bacteria
published pages: 166-175, ISSN: 2161-5063, DOI: 10.1021/acssynbio.7b00266
ACS Synthetic Biology 7/1 2020-03-20
2017 Hung-Ju Chang, Peter L. Voyvodic, Ana Zúñiga, Jérôme Bonnet
Microbially derived biosensors for diagnosis, monitoring and epidemiology
published pages: 1031-1035, ISSN: 1751-7915, DOI: 10.1111/1751-7915.12791
Microbial Biotechnology 10/5 2020-03-20
2016 Sarah Guiziou, Vincent Sauveplane, Hung-Ju Chang, Caroline Clerté, Nathalie Declerck, Matthieu Jules, Jerome Bonnet
A part toolbox to tune genetic expression in Bacillus subtilis
published pages: gkw624, ISSN: 0305-1048, DOI: 10.1093/nar/gkw624
Nucleic Acids Research 2020-03-20
2018 Sarah Guiziou, Federico Ulliana, Violaine Moreau, Michel Leclere, Jerome Bonnet
An Automated Design Framework for Multicellular Recombinase Logic
published pages: 1406-1412, ISSN: 2161-5063, DOI: 10.1021/acssynbio.8b00016
ACS Synthetic Biology 7/5 2020-03-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COMPUCELL" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COMPUCELL" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

DISINTEGRATION (2019)

The Mass Politics of Disintegration

Read More  

SUExp (2018)

Strategic Uncertainty: An Experimental Investigation

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More