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CUSTOM-SENSE SIGNED

Custom-made biosensors – Accelerating the transition to a bio-based economy

Total Cost €

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EC-Contrib. €

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Partnership

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 CUSTOM-SENSE project word cloud

Explore the words cloud of the CUSTOM-SENSE project. It provides you a very rough idea of what is the project "CUSTOM-SENSE" about.

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Project "CUSTOM-SENSE" data sheet

The following table provides information about the project.

Coordinator
FORSCHUNGSZENTRUM JULICH GMBH 

Organization address
address: WILHELM JOHNEN STRASSE
city: JULICH
postcode: 52428
website: www.fz-juelich.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙482˙220 €
 EC max contribution 1˙482˙220 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2021-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙482˙220.00

Map

 Project objective

How will we meet the globally growing demand for pharmaceutically active compounds, nutrients and fine chemicals when crude oil resources are dwindling? For decades, biotechnologists have been engineering microorganisms to produce valuable compounds from sugar and biomass. However, a lack of knowledge regarding the host cell metabolism as well as long and laborious development times render this approach challenging to this day. I want to establish a platform to engineer transcriptional biosensors for the intracellular detection of heterologous compounds in single cells. The application of these sensors in combination with flow cytometry and next-generation sequencing will enable high-throughput engineering of microorganisms at the single-cell level with unprecedented speed and simplicity. In the field of biotechnology, this new technology will be a powerful tool for the (i) accelerated directed evolution of genes and pathways in vivo, (ii) functional integration of heterologous genes or whole synthetic pathways into the metabolism of microorganisms for the production of small valuable metabolites, (iii) genome engineering of industrially relevant microorganisms and (iv) adaptation of production strains to process conditions. Furthermore, during CUSTOM-SENSE, biosensors will also prove to be a valuable tool to answer questions in basic science because they will help to elucidate the function of unknown genes and aid the discovery of novel and unexpected functional links in cellular metabolism. I am in an exclusive position to pursue this goal of developing an engineering platform for custom-made biosensors due to the previous invention of biosensors at IBG-1. The starting grant would allow me to compete with Patrick D. Cirino (University of Houston, USA), who is working on a similar approach, and Christina D. Smolke (Stanford University/Caltech, USA), who is focusing on RNA devices for metabolite detection.

 Publications

year authors and title journal last update
List of publications.
2019 Lion Konstantin Flachbart, Sascha Sokolowsky, Jan Marienhagen
Displaced by Deceivers: Prevention of Biosensor Cross-Talk Is Pivotal for Successful Biosensor-Based High-Throughput Screening Campaigns
published pages: 11, ISSN: 2161-5063, DOI: 10.1021/acssynbio.9b00149
ACS Synthetic Biology epub ahead of print 2019-12-17

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