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Custom-made biosensors – Accelerating the transition to a bio-based economy

Total Cost €


EC-Contrib. €






 CUSTOM-SENSE project word cloud

Explore the words cloud of the CUSTOM-SENSE project. It provides you a very rough idea of what is the project "CUSTOM-SENSE" about.

ibg    cells    integration    demand    sensors    answer    engineer    generation    unknown    smolke    exclusive    stanford    lack    function    position    compete    microorganisms    christina    oil    cell    simplicity    compounds    platform    industrially    how    elucidate    questions    pharmaceutically    biotechnology    science    synthetic    engineering    strains    accelerated    times    flow    discovery    cirino    meet    metabolites    vivo    functional    crude    heterologous    links    sugar    transcriptional    biomass    detection    nutrients    invention    patrick    me    valuable    metabolism    aid    caltech    starting    houston    grant    biotechnologists    pursue    cytometry    single    cellular    unprecedented    powerful    chemicals    rna    regarding    day    render    sense    sequencing    metabolite    made    globally    fine    genes    unexpected    university    dwindling    host    small    basic    combination    decades    usa    active    directed    evolution    laborious    biosensors    am    custom    speed    intracellular    tool    genome    prove    throughput   

Project "CUSTOM-SENSE" data sheet

The following table provides information about the project.


Organization address
city: JULICH
postcode: 52428

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙482˙220 €
 EC max contribution 1˙482˙220 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-STG
 Funding Scheme ERC-STG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2021-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FORSCHUNGSZENTRUM JULICH GMBH DE (JULICH) coordinator 1˙482˙220.00


 Project objective

How will we meet the globally growing demand for pharmaceutically active compounds, nutrients and fine chemicals when crude oil resources are dwindling? For decades, biotechnologists have been engineering microorganisms to produce valuable compounds from sugar and biomass. However, a lack of knowledge regarding the host cell metabolism as well as long and laborious development times render this approach challenging to this day. I want to establish a platform to engineer transcriptional biosensors for the intracellular detection of heterologous compounds in single cells. The application of these sensors in combination with flow cytometry and next-generation sequencing will enable high-throughput engineering of microorganisms at the single-cell level with unprecedented speed and simplicity. In the field of biotechnology, this new technology will be a powerful tool for the (i) accelerated directed evolution of genes and pathways in vivo, (ii) functional integration of heterologous genes or whole synthetic pathways into the metabolism of microorganisms for the production of small valuable metabolites, (iii) genome engineering of industrially relevant microorganisms and (iv) adaptation of production strains to process conditions. Furthermore, during CUSTOM-SENSE, biosensors will also prove to be a valuable tool to answer questions in basic science because they will help to elucidate the function of unknown genes and aid the discovery of novel and unexpected functional links in cellular metabolism. I am in an exclusive position to pursue this goal of developing an engineering platform for custom-made biosensors due to the previous invention of biosensors at IBG-1. The starting grant would allow me to compete with Patrick D. Cirino (University of Houston, USA), who is working on a similar approach, and Christina D. Smolke (Stanford University/Caltech, USA), who is focusing on RNA devices for metabolite detection.


year authors and title journal last update
List of publications.
2019 Lion Konstantin Flachbart, Sascha Sokolowsky, Jan Marienhagen
Displaced by Deceivers: Prevention of Biosensor Cross-Talk Is Pivotal for Successful Biosensor-Based High-Throughput Screening Campaigns
published pages: 11, ISSN: 2161-5063, DOI: 10.1021/acssynbio.9b00149
ACS Synthetic Biology epub ahead of print 2019-12-17

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The information about "CUSTOM-SENSE" are provided by the European Opendata Portal: CORDIS opendata.

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