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CC-LEGO SIGNED

CC-LEGO: robust protein blocks to build cages and layers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 CC-LEGO project word cloud

Explore the words cloud of the CC-LEGO project. It provides you a very rough idea of what is the project "CC-LEGO" about.

slovenia    washington    therapies    rate    interactions    independent    vaccines    cubes    group    beneficiary    cc    acquired    soft    forming    university    writing    lab    2d    created    crossing    fusion    designing    lattices    interfaces    communication    assembling    ccs    transfer    excellence    start    rates    de    interface    programming    toolbox    skills    world    universities    experimentally    tested    novo    inhibitor    human    rigid    performing    interplay    wet    coiled    tetrahedra    networking    homogeneity    successful    domains    blocks    nanomaterials    coupled    10    building    treatment    leader    cages    researcher    rigidly    leadership    weak    precise    offers    advantages    dodecahedra    class    solution    infrastructure    career    computational    natural    50    ecosystem    below    gt    protein    flu    designed    motifs    er    fusing    enabled    place    bundles    self    structures    competitiveness    angles    unprecedented    assemblies    legos    alzheimer    proteins    slovenian    regional    lego    health    publications    gain    drug    coils    oligomerization   

Project "CC-LEGO" data sheet

The following table provides information about the project.

Coordinator		 KEMIJSKI INSTITUT 

Organization address
address: HAJDRIHOVA 19
city: LJUBLJANA
postcode: 1000
website: http://www.ki.si

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Slovenia [SI]
 Total cost 250˙774 €
 EC max contribution 250˙774 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KEMIJSKI INSTITUT SI (LJUBLJANA) coordinator 250˙774.00
2    UNIVERSITY OF WASHINGTON US (SEATTLE WA) partner 0.00

Map

 Project objective

The design of novel proteins offers unprecedented advantages for human health, such as improved vaccines, drug delivery and novel therapies (e.g. a flu inhibitor, treatment of Alzheimer’s). The state of the art of de novo self-assembling protein nanomaterials is based on the design of protein-protein interfaces. However, due to the complex interplay of numerous weak interactions at the interface the success rate of designed assemblies is currently below 10%. This proposal aims to increase the success rate of designing large protein assemblies, by using coiled-coils (CC) at the interface. CCs are some of the best understood protein motifs and can be designed with high success rates (>50%). A set of well-defined building blocks (CC-LEGOs) will be created by rigidly fusing CC bundles and natural oligomerization domains. Due to precise control of crossing angles enabled by the rigid fusion we expect that CC-LEGO structures will have the high design success rate and high solution homogeneity needed for further applications. A toolbox of CC-LEGO blocks will be designed and experimentally tested, capable of forming cages (tetrahedra, cubes, dodecahedra) as well as open 2D lattices.

The experienced researcher (ER) will gain new programming and wet lab skills for protein design through performing world-class research at one of the world’s top universities in a group of a world leader in this field. The expected high impact publications and networking opportunities, coupled with the acquired soft skills in project writing, management, leadership and communication will ensure ER’s competitiveness and enable a successful start of his independent career. Another important impact of the project is the transfer the protein design know-how from the University of Washington to the Slovenian and regional research ecosystem, increasing its excellence. This will be supported by the beneficiary in Slovenia, where most of the wet-lab and computational infrastructure is already in place.

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The information about "CC-LEGO" are provided by the European Opendata Portal: CORDIS opendata.

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