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CC-LEGO: robust protein blocks to build cages and layers

Total Cost €


EC-Contrib. €






 CC-LEGO project word cloud

Explore the words cloud of the CC-LEGO project. It provides you a very rough idea of what is the project "CC-LEGO" about.

solution    assembling    oligomerization    er    computational    self    communication    wet    building    writing    rate    lego    fusing    bundles    acquired    angles    fusion    dodecahedra    legos    human    precise    alzheimer    ccs    rigid    coils    weak    group    structures    competitiveness    below    independent    enabled    de    interface    transfer    washington    vaccines    drug    designing    gain    world    therapies    created    beneficiary    coiled    protein    coupled    excellence    experimentally    interfaces    performing    novo    cc    treatment    skills    advantages    infrastructure    lattices    domains    inhibitor    motifs    health    publications    forming    networking    ecosystem    nanomaterials    universities    leadership    proteins    homogeneity    place    slovenia    cubes    toolbox    designed    rigidly    interactions    rates    researcher    career    soft    50    slovenian    tetrahedra    crossing    class    gt    flu    offers    regional    lab    start    assemblies    interplay    blocks    10    tested    programming    university    natural    leader    cages    2d    unprecedented    successful   

Project "CC-LEGO" data sheet

The following table provides information about the project.


Organization address
address: HAJDRIHOVA 19
postcode: 1000

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Slovenia [SI]
 Total cost 250˙774 €
 EC max contribution 250˙774 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-GF
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2021-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KEMIJSKI INSTITUT SI (LJUBLJANA) coordinator 250˙774.00


 Project objective

The design of novel proteins offers unprecedented advantages for human health, such as improved vaccines, drug delivery and novel therapies (e.g. a flu inhibitor, treatment of Alzheimer’s). The state of the art of de novo self-assembling protein nanomaterials is based on the design of protein-protein interfaces. However, due to the complex interplay of numerous weak interactions at the interface the success rate of designed assemblies is currently below 10%. This proposal aims to increase the success rate of designing large protein assemblies, by using coiled-coils (CC) at the interface. CCs are some of the best understood protein motifs and can be designed with high success rates (>50%). A set of well-defined building blocks (CC-LEGOs) will be created by rigidly fusing CC bundles and natural oligomerization domains. Due to precise control of crossing angles enabled by the rigid fusion we expect that CC-LEGO structures will have the high design success rate and high solution homogeneity needed for further applications. A toolbox of CC-LEGO blocks will be designed and experimentally tested, capable of forming cages (tetrahedra, cubes, dodecahedra) as well as open 2D lattices.

The experienced researcher (ER) will gain new programming and wet lab skills for protein design through performing world-class research at one of the world’s top universities in a group of a world leader in this field. The expected high impact publications and networking opportunities, coupled with the acquired soft skills in project writing, management, leadership and communication will ensure ER’s competitiveness and enable a successful start of his independent career. Another important impact of the project is the transfer the protein design know-how from the University of Washington to the Slovenian and regional research ecosystem, increasing its excellence. This will be supported by the beneficiary in Slovenia, where most of the wet-lab and computational infrastructure is already in place.

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The information about "CC-LEGO" are provided by the European Opendata Portal: CORDIS opendata.

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