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REDOXIT

Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils.

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 REDOXIT project word cloud

Explore the words cloud of the REDOXIT project. It provides you a very rough idea of what is the project "REDOXIT" about.

mix    innovative    tri    groups    cutting    immunology    collaborative    human    edge    surrey    emergent    population    skills    uker    extend    academia    training    redox    molecule    modulators    networking    uses    complementary    chronic    oxygen    germany    aston    vivo    anticipate    species    alexander    encourage    ageing    partite    erythematosus    disease    ab    reaching    vitro    benefit    universitat    stimulate    immune    identification    industry    generate    modulate    ros    diseases    sweden    drug    mediated    oxidation    cross    models    autoimmunity    cells    leaders    area    relevance    regulation    health    arthritis    interchange    tomorrow    redoxis    uk    sle    small    biochemical    candidate    basic    expertise    brings    lupus    transfer    thiol    enzyme    university    nox2    reactive    career    researcher    balanced    biology    friedrich    industrial    proposing    science    animal    biomarker    drugs    systemic    ex    exchange    inflammation   

Project "REDOXIT" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF SURREY 

Organization address
address: Stag Hill
city: GUILDFORD
postcode: GU2 7XH
website: www.surrey.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.surrey.ac.uk/redoxit
 Total cost 144˙000 €
 EC max contribution 144˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2019-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF SURREY UK (GUILDFORD) coordinator 40˙500.00
2    UNIVERSITATSKLINIKUM ERLANGEN DE (ERLANGEN) participant 58˙500.00
3    ASTON UNIVERSITY UK (BIRMINGHAM) participant 31˙500.00
4    REDOXIS AB SE (LUND) participant 13˙500.00

Map

 Project objective

We are proposing a four-year programme of knowledge transfer and networking between University of Surrey (SURREY, UK), Aston University (ASTON, UK), Friedrich-Alexander Universitat (UKER, Germany) and Redoxis AB (Redoxis, Sweden). The project targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immunology and ageing; it brings together the application of small molecule candidate drugs to generate ROS and uses innovative approaches to biomarker identification in models of chronic immune disease. This research has significant potential for application in human health and is of particular relevance to the ageing population. Training, knowledge transfer and skills exchange in this emergent area is important to extend the EU’s reach through cutting edge expertise. Interchange in this way will facilitate and promote early career researcher development into tomorrow’s research leaders. It will encourage new, cross-European collaboration between academia and industry. This tri-partite consortium brings together groups with very complementary expertise for knowledge exchange to benefit early career researchers: ASTON – in the biochemical analyses of ROS; SURREY in thiol oxidation and effects in vitro and ex vivo on and within immune cells relevant for biomarker development in chronic disease; UKER - in animal models of chronic diseases such as systemic lupus erythematosus (SLE) and arthritis; and Redoxis on development of novel drugs that stimulate production of ROS from the NOX2 enzyme as means to modulate chronic inflammation. The project objectives and challenges present a balanced mix between industrial application and basic science, with a focus on knowledge transfer and drug development. Through future collaborative funding, we anticipate far-reaching applications of redox modulators to manage chronic disease and increase the knowledge of both autoimmunity and ageing of the immune system.

 Deliverables

List of deliverables.
Winter School on cell analysis Other 2019-11-29 10:50:34
Summer School on advances in free radical research Other 2019-11-29 10:50:34
Open workshop on inter-sectoral drug development Other 2019-11-29 10:50:34

Take a look to the deliverables list in detail:  detailed list of REDOXIT deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Markus H. Hoffmann, Helen R. Griffiths
The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models
published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.03.016
Free Radical Biology and Medicine 2019-11-29
2018 Viktor Reshetnikov, Jonas Hahn, Christian Maueröder, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir
Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01827
Frontiers in Immunology 9 2019-11-29
2017 Deborah Kienhöfer, Jonas Hahn, Julia Stoof, Janka Zsófia Csepregi, Christiane Reinwald, Vilma Urbonaviciute, Caroline Johnsson, Christian Maueröder, Malgorzata J. Podolska, Mona H. Biermann, Moritz Leppkes, Thomas Harrer, Malin Hultqvist, Peter Olofsson, Luis E. Munoz, Attila Mocsai, Martin Herrmann, Georg Schett, Rikard Holmdahl, Markus H. Hoffmann
Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps
published pages: e92920, ISSN: 2379-3708, DOI: 10.1172/jci.insight.92920
JCI Insight 2/10 2019-11-29

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The information about "REDOXIT" are provided by the European Opendata Portal: CORDIS opendata.

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