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Reactive oxygen species (ROS) as Elixirs against chronic Disease: OXidative regulatory mechanisms In T cells and neutrophils.

Total Cost €


EC-Contrib. €






 REDOXIT project word cloud

Explore the words cloud of the REDOXIT project. It provides you a very rough idea of what is the project "REDOXIT" about.

arthritis    basic    complementary    ros    expertise    biomarker    cutting    benefit    vivo    university    universitat    models    animal    innovative    mediated    researcher    leaders    ex    molecule    enzyme    groups    collaborative    science    extend    industrial    transfer    diseases    tri    biochemical    mix    training    interchange    germany    career    autoimmunity    erythematosus    relevance    anticipate    biology    thiol    candidate    health    redoxis    immunology    aston    population    drug    modulators    oxygen    industry    alexander    human    proposing    stimulate    inflammation    uses    skills    ab    sweden    uk    redox    cross    small    modulate    brings    partite    reactive    friedrich    academia    uker    vitro    surrey    emergent    encourage    reaching    lupus    area    species    ageing    systemic    exchange    networking    oxidation    nox2    balanced    cells    identification    generate    disease    sle    tomorrow    edge    drugs    immune    regulation    chronic   

Project "REDOXIT" data sheet

The following table provides information about the project.


Organization address
address: Stag Hill
postcode: GU2 7XH

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 144˙000 €
 EC max contribution 144˙000 € (100%)
 Programme 1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
 Code Call H2020-MSCA-RISE-2014
 Funding Scheme MSCA-RISE
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2019-06-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF SURREY UK (GUILDFORD) coordinator 40˙500.00
3    ASTON UNIVERSITY UK (BIRMINGHAM) participant 31˙500.00
4    REDOXIS AB SE (LUND) participant 13˙500.00


 Project objective

We are proposing a four-year programme of knowledge transfer and networking between University of Surrey (SURREY, UK), Aston University (ASTON, UK), Friedrich-Alexander Universitat (UKER, Germany) and Redoxis AB (Redoxis, Sweden). The project targets an emerging area of biology, i.e. reactive oxygen species (ROS)-mediated regulation of immunology and ageing; it brings together the application of small molecule candidate drugs to generate ROS and uses innovative approaches to biomarker identification in models of chronic immune disease. This research has significant potential for application in human health and is of particular relevance to the ageing population. Training, knowledge transfer and skills exchange in this emergent area is important to extend the EU’s reach through cutting edge expertise. Interchange in this way will facilitate and promote early career researcher development into tomorrow’s research leaders. It will encourage new, cross-European collaboration between academia and industry. This tri-partite consortium brings together groups with very complementary expertise for knowledge exchange to benefit early career researchers: ASTON – in the biochemical analyses of ROS; SURREY in thiol oxidation and effects in vitro and ex vivo on and within immune cells relevant for biomarker development in chronic disease; UKER - in animal models of chronic diseases such as systemic lupus erythematosus (SLE) and arthritis; and Redoxis on development of novel drugs that stimulate production of ROS from the NOX2 enzyme as means to modulate chronic inflammation. The project objectives and challenges present a balanced mix between industrial application and basic science, with a focus on knowledge transfer and drug development. Through future collaborative funding, we anticipate far-reaching applications of redox modulators to manage chronic disease and increase the knowledge of both autoimmunity and ageing of the immune system.


List of deliverables.
Winter School on cell analysis Other 2019-11-29 10:50:34
Summer School on advances in free radical research Other 2019-11-29 10:50:34
Open workshop on inter-sectoral drug development Other 2019-11-29 10:50:34

Take a look to the deliverables list in detail:  detailed list of REDOXIT deliverables.


year authors and title journal last update
List of publications.
2018 Markus H. Hoffmann, Helen R. Griffiths
The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models
published pages: , ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2018.03.016
Free Radical Biology and Medicine 2019-11-29
2018 Viktor Reshetnikov, Jonas Hahn, Christian Maueröder, Christine Czegley, Luis Enrique Munoz, Martin Herrmann, Markus H. Hoffmann, Andriy Mokhir
Chemical Tools for Targeted Amplification of Reactive Oxygen Species in Neutrophils
published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.01827
Frontiers in Immunology 9 2019-11-29
2017 Deborah Kienhöfer, Jonas Hahn, Julia Stoof, Janka Zsófia Csepregi, Christiane Reinwald, Vilma Urbonaviciute, Caroline Johnsson, Christian Maueröder, Malgorzata J. Podolska, Mona H. Biermann, Moritz Leppkes, Thomas Harrer, Malin Hultqvist, Peter Olofsson, Luis E. Munoz, Attila Mocsai, Martin Herrmann, Georg Schett, Rikard Holmdahl, Markus H. Hoffmann
Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps
published pages: e92920, ISSN: 2379-3708, DOI: 10.1172/jci.insight.92920
JCI Insight 2/10 2019-11-29

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The information about "REDOXIT" are provided by the European Opendata Portal: CORDIS opendata.

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