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BIOLOCHANICS SIGNED

Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine

Total Cost €

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EC-Contrib. €

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Partnership

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 BIOLOCHANICS project word cloud

Explore the words cloud of the BIOLOCHANICS project. It provides you a very rough idea of what is the project "BIOLOCHANICS" about.

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Project "BIOLOCHANICS" data sheet

The following table provides information about the project.

Coordinator
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS 

Organization address
address: BOULEVARD SAINT MICHEL 60
city: PARIS
postcode: 75272
website: www.armines.net

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙396 €
 EC max contribution 1˙999˙396 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS FR (PARIS) coordinator 1˙920˙003.00
2    CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU FR (SAINT ETIENNE) participant 79˙393.00

Map

 Project objective

Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.

 Publications

year authors and title journal last update
List of publications.
2017 Witold Krasny, Claire Morin, Hélène Magoariec, Stéphane Avril
A comprehensive study of layer-specific morphological changes in the microstructure of carotid arteries under uniaxial load
published pages: 342-351, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.033
Acta Biomaterialia 57 2020-03-23
2016 Ambroise Duprey, Olfa Trabelsi, Marco Vola, Jean-Pierre Favre, Stéphane Avril
Biaxial rupture properties of ascending thoracic aortic aneurysms
published pages: 273-285, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.06.028
Acta Biomaterialia 42 2020-03-23
2017 S. Jamaleddin Mousavi, Stéphane Avril
Patient-specific stress analyses in the ascending thoracic aorta using a finite-element implementation of the constrained mixture theory
published pages: 1765-1777, ISSN: 1617-7959, DOI: 10.1007/s10237-017-0918-2
Biomechanics and Modeling in Mechanobiology 16/5 2020-03-23
2018 O. Trabelsi, M. Gutierrez, S. Farzaneh, A. Duprey, S. Avril
A non-invasive methodology for ATAA rupture risk estimation
published pages: 119-126, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2017.11.012
Journal of Biomechanics 66 2020-03-23
2018 Witold Krasny, Hélène Magoariec, Claire Morin, Stéphane Avril
Kinematics of collagen fibers in carotid arteries under tension-inflation loading
published pages: 718-726, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.08.014
Journal of the Mechanical Behavior of Biomedical Materials 77 2020-03-23
2017 Stéphane Avril
Hyperelasticity of Soft Tissues and Related Inverse Problems
published pages: 37-66, ISSN: , DOI: 10.1007/978-3-319-45071-1_2
2020-03-23
2017 F. Condemi, S. Campisi, M. Viallon, T. Troalen, G. Xuexin, A. J. Barker, M. Markl, P. Croisille, O. Trabelsi, C. Cavinato, A. Duprey, S. Avril
Fluid- and Biomechanical Analysis of Ascending Thoracic Aorta Aneurysm with Concomitant Aortic Insufficiency
published pages: 2921-2932, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1913-6
Annals of Biomedical Engineering 45/12 2020-03-23
2016 Matthew R. Bersi, Chiara Bellini, Paolo Di Achille, Jay D. Humphrey, Katia Genovese, Stéphane Avril
Novel Methodology for Characterizing Regional Variations in the Material Properties of Murine Aortas
published pages: 71005, ISSN: 0148-0731, DOI: 10.1115/1.4033674
Journal of Biomechanical Engineering 138/7 2020-03-23
2017 S. Jamaleddin Mousavi, Solmaz Farzaneh, Stéphane Avril
Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms
published pages: e2944, ISSN: 2040-7939, DOI: 10.1002/cnm.2944
International Journal for Numerical Methods in Biomedical Engineering 2020-03-23
2018 Francesca Condemi, Salvatore Campisi, Magalie Viallon, Pierre Croisille, Jean-François Fuzelier, Stéphane Avril
Ascending thoracic aorta aneurysm repair induces positive hemodynamic outcomes in a patient with unchanged bicuspid aortic valve
published pages: 145-148, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.09.022
Journal of Biomechanics 81 2020-03-23
2018 Víctor A. Acosta Santamaría, María Flechas García, Jérôme Molimard, Stephane Avril
Three-Dimensional Full-Field Strain Measurements across a Whole Porcine Aorta Subjected to Tensile Loading Using Optical Coherence Tomography–Digital Volume Correlation
published pages: , ISSN: 2297-3079, DOI: 10.3389/fmech.2018.00003
Frontiers in Mechanical Engineering 4 2020-03-23
2018 V. A. Acosta Santamaría, G. Daniel, D. Perrin, J. N. Albertini, E. Rosset, S. Avril
Model reduction methodology for computational simulations of endovascular repair
published pages: 139-148, ISSN: 1025-5842, DOI: 10.1080/10255842.2018.1427740
Computer Methods in Biomechanics and Biomedical Engineering 21/2 2020-03-23
2019 Matthew R. Bersi, Chiara Bellini, Jay D. Humphrey, Stéphane Avril
Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics
published pages: 203-218, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1077-9
Biomechanics and Modeling in Mechanobiology 18/1 2020-03-23
2018 Nele Famaey, Julie Vastmans, Heleen Fehervary, Lauranne Maes, Emma Vanderveken, Filip Rega, S. Jamaleddin Mousavi, Stéphane Avril
Numerical simulation of arterial remodeling in pulmonary autografts
published pages: 2239-2257, ISSN: 0044-2267, DOI: 10.1002/zamm.201700351
ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/12 2020-03-23
2018 Rossella Campobasso, Francesca Condemi, Magalie Viallon, Pierre Croisille, Salvatore Campisi, Stéphane Avril
Evaluation of Peak Wall Stress in an Ascending Thoracic Aortic Aneurysm Using FSI Simulations: Effects of Aortic Stiffness and Peripheral Resistance
published pages: 707-722, ISSN: 1869-408X, DOI: 10.1007/s13239-018-00385-z
Cardiovascular Engineering and Technology 9/4 2020-03-23
2019 Solmaz Farzaneh, Olfa Trabelsi, Bertrand Chavent, Stéphane Avril
Identifying Local Arterial Stiffness to Assess the Risk of Rupture of Ascending Thoracic Aortic Aneurysms
published pages: , ISSN: 0090-6964, DOI: 10.1007/s10439-019-02204-5
Annals of Biomedical Engineering 2020-03-23
2019 Solmaz Farzaneh, Olfa Trabelsi, Stéphane Avril
Inverse identification of local stiffness across ascending thoracic aortic aneurysms
published pages: 137-153, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1073-0
Biomechanics and Modeling in Mechanobiology 18/1 2020-03-23

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