The page lists 194 projects related to the topic "pharmacological".
| # | |||
|---|---|---|---|
| 1 | OPERAM | OPtimising thERapy to prevent Avoidable hospital admissions in the Multimorbid elderly | 2015 | 
| 2 | PRECIOUS | PREvention of Complications to Improve OUtcome in elderly patients with acute Stroke | 2015 | 
| 3 | REGAIN | REgeneration of inner ear hair cells with GAmma-secretase INhibitors to regain hearing in patients with sensorineural hearing loss | 2015 | 
| 4 | CIRCODE | Cell-type specific mechanisms regulating rhythms in leukocyte homing | 2015 | 
| 5 | DE-ORPHAN | DEtermination of Orphan Receptor PHysiological Agonists and sigNals | 2015 | 
| 6 | aCROBAT | Circadian Regulation Of Brown Adipose Thermogenesis | 2015 | 
| 7 | NABBA | Design and development of advanced NAnomedicines to overcome Biological BArriers and to treat severe diseases | 2015 | 
| 8 | TOLLerant | Toll-Like Receptor 4 activation and function in diseases: an integrated chemical-biology approach. | 2015 | 
| 9 | MiND | Mastering skills in the training Network for attention deficit hyperactivity and autism spectrum Disorders | 2015 | 
| 10 | openMedicine | openMedicine | 2015 | 
| 11 | ADIPOA2 | Clinical trial of autologous adipose-derived mesenchymal stromal cells (ASC) in the treatment of mild to moderate osteoarthritis | 2015 | 
| 12 | GLYCANC | Matrix glycans as multifunctional pathogenesis factors and therapeutic targets in cancer | 2015 | 
| 13 | BIOLOCHANICS | Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine | 2015 | 
| 14 | TentaclesOfVenom | Unravelling the enigmatic origin of venom secreting cells in sea anemone | 2015 | 
| 15 | HoogsCG | Development of a multiscale modeling strategy to decipher how hybrid DNA/RNA triplexes and G-quadruplexes affect gene expression regulation | 2015 | 
| 16 | NIBSAD | Electrophysiological markers of cognitive processes and neuroplasticity in healthy ageing and Alzheimer`s disease | 2015 | 
| 17 | ESATM | Embryonic stem cell origin of the adipose tissue macrophages | 2015 | 
| 18 | TARGEPILIVER | Characterization of Key Epigenetic Targets in Hepatic Fibrosis and Hepatocellular Carcinoma Development. Generation of New Antifibrotic and Antitumoral Drugs. | 2015 | 
| 19 | CODIR | Cortical Dynamics of Decision Irrationality | 2016 | 
| 20 | MediVAC | Bio-sustainable production of natural medicines from Vitex | 2015 | 
| 21 | ChemoBOOM | Development of Palladium-Labile Prodrugs for Bioorthogonally-Activated Chemotherapy | 2016 | 
| 22 | MaSCheNav | Mass Spectrometry-Based Chemoproteomic Profiling of Nav1.7, a Voltage-Gated Sodium Channel | 2015 | 
| 23 | NovLeuReg | Identification and characterization of novel essential regulators of acute myeloid leukemia | 2016 | 
| 24 | nAChR PAM-to-gate | Gating mechanism and pharmacological modulation of nicotinic acetylcholine receptors | 2015 | 
| 25 | depreg | Antidepressants during pregnancy: underlying mechanisms associated with neurodevelopmental outcome | 2015 | 
| 26 | Re.B.Us | Rewiring Brain Units - bridging the gap of neuronal communication by means of intelligent hybrid systems | 2016 | 
| 27 | VMHCIRCUITS | Deciphering central role of VMH circuits in regulating energy balance | 2015 | 
| 28 | TITLY | Inhibition of the T-cell receptor signalling pathway for treatment of T-cell lymphoma | 2015 | 
| 29 | EPI_nanoSTIM | Enabling motor control after a spinal cord injury through nanoscaled electrical | 2015 | 
| 30 | NANOTAM | Development and Evaluation of Nanomedicines for Cancer Treatment through Immunomodulation: Targeting Tumor-Associated Macrophages | 2015 | 
| 31 | REGHA | Medical device combining viscosupplementation with pharmacological active molecule to regenerate cartilage in degenerative or traumatic osteoarthritis. | 2015 | 
| 32 | NeuroInCellNMR | In-cell NMR monitoring of alpha-Synuclein aggregation in neuronal cells | 2015 | 
| 33 | BLOSTER | Innovative biopesticides production: valorisation of endemic plants and green industrial residues | 2015 | 
| 34 | PRIISM-HD | Pathways Regulating Intramyocellular Insulin Sensitivity and Metabolism in Health and Disease | 2016 | 
| 35 | UPR NEURO | The Unfolded Protein Response in Neurodegeneration | 2015 | 
| 36 | AFib-TrainNet | EU Training Network on Novel Targets and Methods in Atrial Fibrillation | 2015 | 
| 37 | p38Cure | New breast cancer therapies based on available p38 MAPK inhibitors | 2015 | 
| 38 | WipeOutFear | How the Brain Learns to Forget - The Neural Signature of Fear Memory Erasure | 2015 | 
| 39 | CRADLE | Cancer treatment during pregnancy: from fetal safety to maternal efficacy | 2015 | 
| 40 | MAGNEURON | Hijacking cell signalling pathways with magnetic nanoactuators for remote-controlled stemcell therapies of neurodegenerative disorders | 2016 | 
| 41 | rEnDOx | REDOX SIGNALING AND METABOLIC STATES IN ANGIOGENESIS IN HEALTH AND DISEASE | 2016 | 
| 42 | CoCA | Comorbid Conditions of Attention deficit / hyperactivity disorder | 2016 | 
| 43 | StemBAT | New players in human BAT differentiation and activation: a human PSC-derived BAT approach combined with state of the art genome engineering and –omics based methodologies | 2016 | 
| 44 | MediHealth | Novel natural products for healthy ageing from Mediterranean diet and food plants of other global sources | 2016 | 
| 45 | GLION | Investigating glial glycogen utilization for ion homeostasis in the brain and its relevance to epileptogenesis: electrophysiology and pharmacology in awake behaving mice | 2016 | 
| 46 | Yamnomics | Phylogenomics, evolution, biogeography and key traits for breeders in yams (Dioscorea, Dioscoreaceae) | 2017 | 
| 47 | CMIL | Crosstalk of Metabolism and Inflammation | 2016 | 
| 48 | Remote memory traces | Cellular and molecular mechanisms of remote fear attenuation | 2016 | 
| 49 | STEMBAR | Mechanisms and functional significance of diffusion barriers for asymmetric segregation of age in neural stem cells | 2016 | 
| 50 | PreventStoCan | Understanding microbe-induced stomach cancer – the key to a workable strategy for worldwide prevention | 2016 | 
| 51 | MAST4HEALTH | Mastiha treatment for healthy obese with NAFLD diagnosis (MAST4HEALTH). | 2016 | 
| 52 | OptoNMDA | Optical strategies to investigate NMDA receptor functional diversity and its therapeutic potential | 2016 | 
| 53 | Cleanup-MOFs | Decontamination of emerging pollutant using porous Metal-Organic Frameworks (MOFs) and silica-MOFs composites | 2016 | 
| 54 | CAMEOS | Cardiac micro-engineered tissue for high-throughput screening | 2016 | 
| 55 | SiCMetabol | Signaling Cascades in Metabolic Diseases | 2016 | 
| 56 | Skye | A programming language bridging theory and practice for scientific data curation | 2016 | 
| 57 | CF_struct | High-Resolution X-ray Structures of Full-Length Cystic Fibrosis Transmembrane Conductance Regulator | 2016 | 
| 58 | EpiHope | Epigenetic biomarkers for prediction of vascular complications and response to treatment in subjects with diabetes | 2016 | 
| 59 | AGE-MEMORY | Identification of insulin signalling factors that delay age-related memory impairment | 2016 | 
| 60 | iRELaTE | Immune Response and Social Cognition in Schizophrenia | 2016 | 
| 61 | SYNAPLAST MR | Imaging synaptic plasticity by ultra-high field magnetic resonance spectroscopy in health and psychiatric disease | 2016 | 
| 62 | ImmunoBile | Bile acid, immune-metabolism, lipid and glucose homeostasis | 2016 | 
| 63 | PCFENCM | Pan-cancer functional evaluation of non-coding DNA mutations | 2017 | 
| 64 | IMPAX | Inline/Instant Measurement for PhArma eXtrusion | 2016 | 
| 65 | SensoNMDA | Impact of NMDA receptor diversity in sensory information processing | 2016 | 
| 66 | PERCEPT | The mind's eye: How expectation and attention shape perception | 2016 | 
| 67 | AutoStopS | GluCl as an epileptic seizure autoregulatory Gene therapeutic approach | 2016 | 
| 68 | Neobetacell | Neogenesis of new functional Beta Cells through Modulation of Neurogenin-3 Expression to provide Regenerative Therapy for Diabetes Patients | 2016 | 
| 69 | TREATMENT | Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia | 2017 | 
| 70 | EPIPHARM | Development of a ncRNA DNA Methylation Kit for Treatment Guidance in Cancer of Unknown Primary | 2017 | 
| 71 | THERACAN | Novel therapeutic strategies to treat pancreatic and lung cancer | 2017 | 
| 72 | Diet-namic | From fast food to healthy diet: Addressing the dynamic molecular mechanism of sequential diet switch-induced T cell plasticity for the purpose of developing new treatments for immuno-mediated diseases | 2016 | 
| 73 | CD40-INN | CD40 goes innate: defining and targeting CD40 signaling intermediates in the macrophage to treat atherosclerosis | 2016 | 
| 74 | CUPIDO | Cardio Ultraefficient nanoParticles for Inhalation of Drug prOducts | 2017 | 
| 75 | ALS-Networks | Defining functional networks of genetic causes for ALS and related neurodegenerative disorders | 2017 | 
| 76 | INHIBITHUMAN | Dis-inhibitory circuits in the human cerebral cortex | 2016 | 
| 77 | PREVMETSYN | SMALL MOLECULES TO TREAT METABOLIC SYNDROME | 2017 | 
| 78 | Olive-Net | Bioactive compounds from Olea europaea: investigation and application in food, cosmetic and pharmaceutical industry | 2017 | 
| 79 | BONEPHAGY | Defining the role of the FGF – autophagy axis in bone physiology | 2017 | 
| 80 | Keep Control | Industrial Academic Initial Training Network towards specific diagnosis and treatment of age-related gait and balance deficits | 2017 | 
| 81 | TREATCilia | Novel Therapeutic Avenues for dynein-related Ciliopathies | 2017 | 
| 82 | iTRUST | iTRUST: In-time TReatment of acUte ischaemic STroke | 2017 | 
| 83 | CONSCIOUSNESS | Towards a neural and cognitive architecture of consciousness | 2017 | 
| 84 | FLUDD | Late Stage Fluorination and its Applications to Drug Discovery | 2017 | 
| 85 | MitoDyaD | The role of the glucocorticoid receptor in dopaminoceptive neurons in mitochondrial dysfunction and vulnerability to depression | 2017 | 
| 86 | DIRECtA | Targeting the Endocannabinoid System within Islets of Langerhans to Protect against Immune Destruction. | 2018 | 
| 87 | PHOTORNA | Development of photoswitchable ligands for the reversible and selective assembly with RNA | 2017 | 
| 88 | CNS-Insuin-Res | How insulin resistance in the dorsal vagal complex affects glucose metabolism and feeding behaviour | 2017 | 
| 89 | EwiSarc | A novel in vivo platform to study and target undruggable Ewing onco-chimera. | 2017 | 
| 90 | MetEpiClock | Circadian Control of Histone Methylation Dynamics through the Fine-tuning of Methionine Metabolic Flux | 2017 | 
| 91 | MOBER | Maternal Obesity and Epigenetic Reprogramming: from Gametogenesis to Early Embryonic Development | 2017 | 
| 92 | Immunometabolomics | CD8+ T cell metabolism in anti-tumor response | 2017 | 
| 93 | TransQST | Translational quantitative systems toxicology to improve the understanding of the safety of medicines - Sofia: 116030 | 2017 | 
| 94 | ContraNPM1AML | Dissecting to hit the therapeutic targets in nucleophosmin (NPM1)-mutated acute myeloid leukemia | 2017 | 
| 95 | Motivageing | Motivation–cognition interaction in healthy ageing and Parkinson’s disease | 2018 | 
| 96 | Signalling-in-NODs | Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation | 2017 | 
| 97 | ZECARDIO | Cardiotoxicity High-throughput screening (HTS) with zebrafish embryo | 2017 | 
| 98 | BEAT | The functional interaction of EGFR and beta-catenin signalling in colorectal cancer: Genetics, mechanisms, and therapeutic potential. | 2017 | 
| 99 | ESCAPE_COPD | Elimination of Senescent Cells Approach for treatment of COPD | 2017 | 
| 100 | UNREDE | Understanding Non-Photochemical Quenching Regulation in a Dynamic Environment. | 2018 | 
| 101 | DrugComb | Informatics approaches for the rational selection of personalized cancer drug combinations | 2017 | 
| 102 | GenEdiDS | Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome | 2017 | 
| 103 | NAFLDcure | A novel pharmaceutical treatment for nonalcoholic fatty liver disease | 2017 | 
| 104 | SOCIORATS | Social Distress Response in the Context of Empathy in Rats | 2017 | 
| 105 | MOWOOT | Integral Intestinal Transit Management System for chronic constipation | 2017 | 
| 106 | XANA | Innovative Wearable and Open Platform for a Personalized Treatment of Stress | 2017 | 
| 107 | BBCE | Baltic Biomaterials Centre of Excellence | 2017 | 
| 108 | UbiCODE | European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets | 2018 | 
| 109 | V-EPC | Inherited disfunctions of brain microcirculation | 2017 | 
| 110 | PurinesDX | Interdisciplinary training network on the purinergic P2X7 receptor to control neuroinflammation and hyperexcitability in brain diseases. | 2017 | 
| 111 | Dam2Age | DNA Damage and Repair and its Impact on Healthy Ageing | 2017 | 
| 112 | TRIPLECON | Triple negative breast cancer control through synergistic inhibition of EGFR and CDK9 signaling | 2017 | 
| 113 | ERACHRON | Eradicating Chronic Infections | 2018 | 
| 114 | X-TAM | Dissecting Cross-Regulatory Interplays in Tumor-Associated Macrophages | 2018 | 
| 115 | INSIST | IN-Silico trials for treatment of acute Ischemic STroke | 2017 | 
| 116 | EDIReX | EurOPDX Distributed Infrastructure for Research on patient-derived cancer Xenografts | 2018 | 
| 117 | GeroProtect | Developing Geroprotectors to Prevent Polymorbidity | 2017 | 
| 118 | CESYDE | Ceramide Synthases in Diabetic Beta Cell Demise | 2018 | 
| 119 | COLOSTEO | Nutraceutical supplementation based on colostrum for prevention of osteoporosis | 2018 | 
| 120 | Damocles | Modelling brain aneurysm to elucidate the role of platelets | 2018 | 
| 121 | BCPPlus | New directions in bicyclopentane research | 2018 | 
| 122 | KARhet | Molecular architecture of heteromeric kainate receptor complexes | 2018 | 
| 123 | INTERGLU | Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools | 2018 | 
| 124 | PhenoSwitch | Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate. | 2018 | 
| 125 | NoMePaCa | Novel Metabolic Pathways in Cancer | 2018 | 
| 126 | TRECEPTORS | Transport and Receptor Mechanisms of Human Solute Carriers | 2018 | 
| 127 | VolThinSens | VolThinSens. Challenging societal needs involving ions detection: New strategies for the development of Voltammetry ion Sensors based on Thin membranes | 2018 | 
| 128 | NaKStruc | Structural studies of Na,K-ATPase isoforms and mutants | 2018 | 
| 129 | PREMEDiCARE | PREcision MEDicine with induced pluripotent stem cells for Cardiac Arrhythmias Risk Evaluation | 2018 | 
| 130 | GlycoPCs | How do Pharmacological Chaperones work? Molecular basis of the actions of glycomimetics on keyglycosidases involved in lysosomal storage disorders | 2018 | 
| 131 | GEMZ | Genetic Epilepsy Models in Zebrafish | 2019 | 
| 132 | DARE2APPROACH | Dare to Approach: A Neurocognitive Approach to Alleviating Persistent Avoidance in Anxiety Disorders | 2019 | 
| 133 | MiCaBra | Mitochondrial Cannabinoid Receptors in the Brain | 2018 | 
| 134 | DYNACOTINE | Signal transduction and allosteric modulation of nicotinic acetylcholine receptors:from ion channel electrophysiology to atomic 3D structures | 2019 | 
| 135 | Gut_Fights_PD | Investigating protective mechanisms of gut bacteria in C. elegans models of Parkinson’s disease | 2019 | 
| 136 | MIN4ALD | Use of MIN-102 for the treatment of children with cerebral ALD | 2018 | 
| 137 | SWIRL | Short, weakly interacting RNA ligands for the development of high-concentration monoclonal antibody therapeutics | 2018 | 
| 138 | PIcelles | Penetration-promoting and Imageable Polymeric Micelles as a Platform Technology for Individualized and Improved Tumor-targeted Drug Delivery | 2018 | 
| 139 | PROVEC | Promoting Osteogenesis through Vascular Endothelial Cells | 2019 | 
| 140 | NEODYNE | Decision making: from neurochemical mechanisms to network dynamics to behaviour | 2018 | 
| 141 | LIGHTPORT | From light-stimulated anion receptors to transmembrane carriers and pumps | 2019 | 
| 142 | ImAgine | Exploring the link between innate Immunity and cellular Aging | 2019 | 
| 143 | HD4HF | Heart Damper: a revolutionary device for Heart Failure | 2018 | 
| 144 | kINPen | Developing a high-innovative portable cold plasma device for efficient healing of chronic wounds in veterinary medicine | 2019 | 
| 145 | TIL-FIT | Increasing the fitness of tumor-infiltrating T cells for cellular immunotherapy | 2019 | 
| 146 | SINSTRO | Unique approach to improving neurological function after stroke with SIN020 | 2019 | 
| 147 | 3DLT | 3D Living Tissues | 2019 | 
| 148 | LION-HEARTED | Light and Organic Nanotechnology for Cardiovascular Disease | 2019 | 
| 149 | NanoBRIGHT | BRInGing nano-pHoTonics into the brain | 2019 | 
| 150 | Brain Health Toolbox | The Brain Health Toolbox: Facilitating personalized decision-making for effective dementia prevention | 2019 | 
| 151 | Capsulight | The first ingestible capsule for eradicating Helicobacter pylori infection through photodynamic therapy | 2019 | 
| 152 | PREFERABLE | Project on Exercise for Fatigue Eradication in Advanced Breast cancer to improve quality of life | 2019 | 
| 153 | PsychAID | Psychiatric Disorders: ATX-inhibiting drugs as a new therapeutic option: Proof-of-Concept | 2019 | 
| 154 | AgePhagy | An integrated high-throughput human cell and Drosophila screening platform for the expedited discovery of anti-ageing compounds | 2019 | 
| 155 | Oncogenic PI3-kinase | New biology of oncogenic PI 3-kinase | 2019 | 
| 156 | TaPPiNG-EPI | Targeting Purinergic Pathway in drug-resistant epilepsy using human Neurons and Glia. | 2019 | 
| 157 | eBAT | Enhancing brown adipose tissue through NAD+ precursors: a new approach to treat cardiometabolic disease | 2019 | 
| 158 | TFZN | Understanding the mechanisms that govern organ morphostasis and repair | 2019 | 
| 159 | BICE | Behavioural Individuality in C. elegans | 2020 | 
| 160 | COATING | COATING - slippery wires: revolutionizing COronAry sTentING | 2019 | 
| 161 | DADA2GT | Development of gene therapy and genome editing strategies to treat adenosine deaminase 2 deficiency | 2019 | 
| 162 | MDR | Structural and functional characterization of MAVS-DDX3-vRNA complex | 2019 | 
| 163 | Food-PPP-NAFLD | Discovery and characterization of food bioactive compounds modulating the Pentose Phosphate Pathway against non-alcoholic fatty liver disease. | 2019 | 
| 164 | DISCONNECTOME | Brain connections, Stroke, Symptoms Predictions and Brain Repair | 2019 | 
| 165 | uKNEEversal | uKNEEversal: a miniaturized 3D in vitro model of human joint to gain new knowledge on Osteoarthritis pathophysiology | 2019 | 
| 166 | MS4Drug | An Innovative Mass Spectrometry-Based Workflow for Drug Discovery | 2019 | 
| 167 | UnravelOxStress | Oxygen, telomeres and sex: experimental elucidation of oxidative stress effects in life history evolution | 2020 | 
| 168 | SCAFFOLD-NEEDS | Commercialization of 3D scaffold platforms for neuronal cell culture models | 2019 | 
| 169 | NO-GO | NO-GO: UNVEILING THE POWER OF C-08 FOR THE TREATMENT OF OVER ACTIVE BLADDER | 2019 | 
| 170 | NeoCellBank | A revolutionary regenerative therapy for management of chronic inflammatory diseases based on neonatal Mesenchymal Stem Cells | 2019 | 
| 171 | RAPID | The first effective remedy for acute pancreatitis disease | 2019 | 
| 172 | EYELETS | A regenerative medicine approach in diabetes. | 2020 | 
| 173 | LIV-AD-ON-CHIP | Unmasking insulin resistance triggering mechanisms using microphysiological two-organ systems as in vitro disease models of metabolic syndrome and non-alcoholic fatty liver disease | 2020 | 
| 174 | NeoPur | New treatments and novel diagnostic tests for neonatal seizures based on purinergic signaling. | 2019 | 
| 175 | INTERGLP1 | Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools | 2020 | 
| 176 | SPELITEC | Sequence sPecific ELImination of shiga-Toxin E. Coli | 2019 | 
| 177 | Angio-NYT | Investigating the crosstalk between Notch and YAP/TAZ in sprouting angiogenesis | 2020 | 
| 178 | LongActNow | Long Acting Medicines for Complex Therapeutics Needed Now | 2019 | 
| 179 | ESPS | Epileptic Seizure Prediction System (ESPS) - Predicting and preventing epileptic seizures based on respiratory biofeedback & machine learning. | 2019 | 
| 180 | AlgaHealth | AlgaHealth: novel cultivation technologies of unique microalgae strains for high quality of fucoxanthin-based products. | 2019 | 
| 181 | CANCERPREV | Innovative strategies for cancer prevention with focus on sex hormone signaling and chronic inflammation | 2019 | 
| 182 | TIPAT | Training towards Personalized Antibiotic Treatment | 2020 | 
| 183 | IMPACT | Implementation of ACT in Daily Life | 2019 | 
| 184 | CYPNASH | Validation of a novel class of cyclophilin inhibitors for the treatment of non-alcoholic steatohepatitis | 2019 | 
| 185 | InflaPML | Promyelocytic leukemia protein (PML) outside the tumor: a new player in the control of inflammation | 2020 | 
| 186 | MEPHOS | Shaping the Mechano-Pharmacological properties of Microparticles and Extracellular Vesicles for the Treatment of Osteoarthritis | 2020 | 
| 187 | InterTAU | Integrative structural biology of pathological tau protein, an appealing therapeutic target for Alzheimer´s disease modifying drugs | 2020 | 
| 188 | LTS | LEARNING TO SLEEP: INCREASING HEALTH THROUGH BETTER SLEEP | 2020 | 
| 189 | ERA4TB | EUROPEAN REGIMEN ACCELERATOR FOR TUBERCULOSIS | 2020 | 
| 190 | Meta-Targeting | Macro-Nanomedicine to Treat Metastatic Cancer | 2020 | 
| 191 | inhibiTOR | Novel selective mTORC1 inhibitors | 2020 | 
| 192 | C.A.R.E. OA | Cross-linking Adenosine Receptors - Estrogen receptors for OA treatment | 2021 | 
| 193 | MechanoSelfFate | Role of Tissue Mechanics in Embryonic Self-Organization and Cell Fate Plasticity | 2020 | 
| 194 | PregnancyAD | Antidepressant discontinuation during pregnancy and relapse risk in the perinatal period | 2021 |