Explore the words cloud of the NewSpindleForce project. It provides you a very rough idea of what is the project "NewSpindleForce" about.
The following table provides information about the project.
RUDER BOSKOVIC INSTITUTE
|Coordinator Country||Croatia [HR]|
|Total cost||2˙150˙000 €|
|EC max contribution||2˙150˙000 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2015-04-01 to 2020-03-31|
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|1||RUDER BOSKOVIC INSTITUTE||HR (ZAGREB)||coordinator||2˙150˙000.00|
At the onset of division the cell forms a spindle, a micro-machine made of microtubules, which divide the chromosomes by pulling on kinetochores, protein complexes on the chromosome. The central question in the field is how accurate chromosome segregation results from the interactions between kinetochores, microtubules and the associated proteins. According to the current paradigm, the forces on kinetochores are produced by k-fibers, bundles of microtubules extending between the spindle pole and the kinetochore. The proposed project is built upon a groundbreaking hypothesis that a new class of microtubules, which we term bridging microtubules, bridge sister kinetochores. Our preliminary results show that bridging microtubules are responsible for the positioning of kinetochores in HeLa and PtK1 cells. Bridging microtubules have not been studied before because this requires cutting-edge microscopy and laser microsurgery techniques. By applying these methods, with which I have extensive expertise, we will determine the organization of these microtubules, identify the proteins that link them with k-fibers, and uncover where and how the forces for kinetochore positioning and movement are generated. My strength is in taking an interdisciplinary approach, which I will use in this project by combining laser microsurgery with genetic perturbations, quantitative measurements of the responses and comparison with theoretical models. Understanding the role of bridging microtubules in force generation and chromosome movements will not only shed light on the mechanism of chromosome segregation, but may also increase the potential of mitotic anticancer strategies, as the spindle is a major target for chemotherapy. The proposed ERC funding is essential for the success of these timely and ambitious experiments, allowing me to strengthen my position as an international leader in research on cell division, thereby increasing Europe's foremost position in this field.
|year||authors and title||journal||last update|
Iva M. ToliÄ‡, Maja Novak, Nenad Pavin
Helical Twist and Rotational Forces in the Mitotic Spindle
published pages: 132, ISSN: 2218-273X, DOI: 10.3390/biom9040132
Iva M. ToliÄ‡, Nenad Pavin
Bridging the gap between sister kinetochores
published pages: 1169-1170, ISSN: 1538-4101, DOI: 10.1080/15384101.2016.1157976
|Cell Cycle 15/9||2019-05-31|
Bruno Polak, Patrik Risteski, Sonja Lesjak, Iva M ToliÄ‡
PRC1â€labeled microtubule bundles and kinetochore pairs show oneâ€toâ€one association in metaphase
published pages: 217-230, ISSN: 1469-221X, DOI: 10.15252/embr.201642650
|EMBO reports 18/2||2019-05-31|
Iva M. ToliÄ‡
Mitotic spindle: kinetochore fibers hold on tight to interpolar bundles
published pages: , ISSN: 0175-7571, DOI: 10.1007/s00249-017-1244-4
|European Biophysics Journal||2019-05-31|
Nenad Pavin, Iva M. ToliÄ‡
Self-Organization and Forces in the Mitotic Spindle
published pages: 279-298, ISSN: 1936-122X, DOI: 10.1146/annurev-biophys-062215-010934
|Annual Review of Biophysics 45/1||2019-05-31|
Janko Kajtez, Anastasia Solomatina, Maja Novak, Bruno Polak, Kruno VukuÅ¡iÄ‡, Jonas RÃ¼diger, Gheorghe Cojoc, Ana Milas, Ivana Å umanovac Å estak, Patrik Risteski, Federica Tavano, Anna H. Klemm, Emanuele Roscioli, Julie Welburn, Daniela Cimini, Matko GlunÄiÄ‡, Nenad Pavin, Iva M. ToliÄ‡
Overlap microtubules link sister k-fibres and balance the forces on bi-oriented kinetochores
published pages: 10298, ISSN: 2041-1723, DOI: 10.1038/ncomms10298
|Nature Communications 7||2019-05-31|
Anna H. Klemm, Agneza Bosilj, Matko GluncË‡icÂ´, Nenad Pavin, Iva M. TolicÂ´
Metaphase kinetochore movements are regulated by kinesin-8 motors and microtubule dynamic instability
published pages: 1332-1345, ISSN: 1059-1524, DOI: 10.1091/mbc.e17-11-0667
|Molecular Biology of the Cell 29/11||2019-05-31|
R. BuÄ‘a, K. VukuÅ¡iÄ‡, I.M. ToliÄ‡
Dissection and characterization of microtubule bundles in the mitotic spindle using femtosecond laser ablation.
published pages: 81-101, ISSN: , DOI: 10.1016/bs.mcb.2016.11.007
|Methods in Cell Biology 139: 81â€“101 (2017)||2019-05-31|
Ana Milas, Iva ToliÄ‡
Relaxation of interkinetochore tension after severing of a k-fiber depends on the length of the k-fiber stub
published pages: , ISSN: 2297-9239, DOI: 10.19185/matters.201603000025
|Matters Select Mar 23rd, 2016||2019-05-31|
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