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AUTOOLIGO

Automated synthesis of S. pneumoniae 7F capsular polysaccharide repeating unit as candidate for conjugate vaccines

Total Cost €

0

EC-Contrib. €

0

Partnership

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Project "AUTOOLIGO" data sheet

The following table provides information about the project.

Coordinator
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV 

Organization address
address: HOFGARTENSTRASSE 8
city: MUENCHEN
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://n.a.
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

The goal of this project is to develop an automated synthesis of the Streptococcus pneumoniae 7F capsular polysaccharide repeating unit, which is of high interest for synthetic vaccines against this pathogen. This structural motif has never been synthesized yet, not even by traditional solution techniques. Our approach is highly innovative in the application of automated oligosaccharide synthesis, which will make the synthetic procedure more time- and cost-effective. In the course of the project, a series of orthogonally protected monosaccharide building blocks will be synthesized. The oligosaccharide will be assembled on oligosaccharide synthesizer. Photocleavage in a flow reactor and global deprotection will yield the target molecule. The oligosaccharide will be subjected to bioconjugation with a CRM197 carrier protein to produce conjugate vaccine candidate. This conjugate will be tested for the ability to induce an immune response against S. penumoniae 7F.

 Publications

year authors and title journal last update
List of publications.
2016 Sharavathi Guddehalli Parameswarappa, Katrin Reppe, Andreas Geissner, Petra Ménová, Subramanian Govindan, Adam D.J. Calow, Annette Wahlbrink, Markus W. Weishaupt, Bopanna Ponnappa Monnanda, Roland Lawrence Bell, Liise-Anne Pirofski, Norbert Suttorp, Leif Erik Sander, Martin Witzenrath, Claney Lebev Pereira, Chakkumkal Anish, Peter H. Seeberger
A Semi-synthetic Oligosaccharide Conjugate Vaccine Candidate Confers Protection against Streptococcus pneumoniae Serotype 3 Infection
published pages: 1407-1416, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2016.09.016
Cell Chemical Biology 23/11 2019-07-23

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