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Molecular Mechanisms Linking Psychological Stress and Ageing-Related Disease

Total Cost €


EC-Contrib. €






Project "STRESSAGED" data sheet

The following table provides information about the project.


Organization address
postcode: 80539
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Ageing-related diseases are the leading causes of morbidity and mortality. A ubiquitous and potentially preventable factor predisposing to their development is psychological stress, but the molecular mechanisms underlying this relation are largely unknown. This knowledge gap is addressed by the proposed project, which examines epigenetic modifications and, in particular, DNA methylation changes as molecular signatures that may be induced by lifetime stressors and act in concert with advancing age to shape disease risk. The proposed fellow will first identify the DNA methylation sites that are regulated by stressors and ageing and will then examine how these epigenomic sites determine gene expression and disease outcomes. Among key biological processes, the project will focus on immune dysregulation, a common pathogenic process for several diseases of the ageing. Immune dysregulation will be examined in the periphery but also in the brain, the orchestrator of behavioral, neuroendocrine and immune responses. The project will engage translational approaches using both human samples and animal models, implemented via collaborations among leading institutions and experts in Europe and USA. The applicant has unique interdisciplinary skills to carry out the project, including clinical background as well as experience in both clinical and basic research projects on the two fields brought together in the proposal, the biology of stress and ageing-related diseases. The impact of the project can be tremendous, since elucidating the molecular mechanisms of ageing-related diseases would contribute to the development of biomarkers, targeted prevention strategies and novel treatments for these devastating diseases.


year authors and title journal last update
List of publications.
2016 Naama Volk, Julius C. Pape, Mareen Engel, Anthony S. Zannas, Nadia Cattane, Annamaria Cattaneo, Elisabeth B. Binder, Alon Chen
Amygdalar MicroRNA-15a Is Essential for Coping with Chronic Stress
published pages: 1882-1891, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2016.10.038
Cell Reports 17/7 2019-07-23
2015 Anthony S. Zannas, Janine Arloth, Tania Carrillo-Roa, Stella Iurato, Simone R?h, Kerry J. Ressler, Charles B. Nemeroff, Alicia K. Smith, Bekh Bradley, Christine Heim, Andreas Menke, Jennifer F. Lange, Tanja Br?ckl, Marcus Ising, Naomi R. Wray, Angelika Erhardt, Elisabeth B. Binder, Divya Mehta
Lifetime stress accelerates epigenetic aging in an urban, African American cohort: relevance of glucocorticoid signaling
published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-015-0828-5
Genome Biology 16/1 2019-07-23
2016 Anthony S. Zannas
Editorial Perspective: Psychological stress and epigenetic aging - what can we learn and how can we prevent?
published pages: 674-675, ISSN: 0021-9630, DOI: 10.1111/jcpp.12535
Journal of Child Psychology and Psychiatry 57/6 2019-07-23
2017 Rebecca T Emeny, Jens Baumert, Anthony S Zannas, Sonja Kunze, Simone Wahl, Stella Iurato, Janine Arloth, Angelika Erhardt, Georgia Balsevich, Mathias V Schmidt, Peter Weber, Anja Kretschmer, Liliane Pfeiffer, Johannes Kruse, Konstantin Strauch, Michael Roden, Christian Herder, Wolfgang Koenig, Christian Gieger, Melanie Waldenberger, Annette Peters, Elisabeth B Binder, Karl-Heinz Ladwig
Anxiety Associated Increased CpG Methylation In The Promoter of Asb1: A Translational Approach Evidenced By Epidemiological And Clinical Studies And A Murine Model
published pages: , ISSN: 0893-133X, DOI: 10.1038/npp.2017.102
Neuropsychopharmacology 2019-07-23

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