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GelSwimming SIGNED

Bacterial motion in polymer solutions and biogels

Total Cost €

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EC-Contrib. €

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Partnership

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Project "GelSwimming" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-02-26   to  2018-02-25

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 195˙454.00

Map

 Project objective

Many cavities in the human body such as the lungs, the stomach or the reproductive tract are covered and protected by a thin layer of mucus gel. Under certain conditions pathogenic bacteria are able to penetrate the mucus layer which leads to serious infections. For example, in cystic fibrosis motile bacteria swim through the mucus layer and form biofilms which can be resistant to antibiotic medication. Interestingly, corals in the ocean are also covered by mucus. Again, pathogenic bacteria are able to penetrate the coral mucus layer and cause serious diseases resulting in a world-wide decline of corals. The underlying mechanisms how the bacteria are able to move through mucus are not yet understood. We aim, in our proposal, to clarify physical conditions under which bacterial locomotion in polymer solutions and gels is possible. In contrast to existing theories on swimming in viscoelastic fluids we explicitly model the gel and the bacteria via mesoscale computer simulations. Our novel approach will enable us to identify the microscopic conditions for bacterial locomotion in gels and the conditions for immobility (gel-trapping). Our findings may also inspire biologists and medical researchers in designing novel medication and finding strategies to avoid bacterial invasion into mucus of relevance to both the prevention of human disease and the degradation of corals.

 Publications

year authors and title journal last update
List of publications.
2017 Andreas Zöttl and Julia M. Yeomans
Enhanced bacterial swimming speeds in macromolecular polymer solutions
published pages: , ISSN: , DOI:
Nature Physics (under revision) 2019-06-07
2017 Andrew K. Balin, Andreas Zöttl, Julia M. Yeomans, Tyler N. Shendruk
Biopolymer dynamics driven by helical flagella
published pages: , ISSN: 2469-990X, DOI: 10.1103/physrevfluids.2.113102
Physical Review Fluids 2/11 2019-06-07
2018 Daiki Matsunaga, Andreas Zöttl, Fanlong Meng, Ramin Golestanian, and Julia M. Yeomans
Far-field theory for trajectories of magnetic ellipsoids in rectangular and circular channels
published pages: , ISSN: , DOI:
IMA J. Appl. Math (accepted) 2019-06-07
2017 Daiki Matsunaga, Fanlong Meng, Andreas Zöttl, Ramin Golestanian, Julia M. Yeomans
Focusing and Sorting of Ellipsoidal Magnetic Particles in Microchannels
published pages: , ISSN: 0031-9007, DOI: 10.1103/physrevlett.119.198002
Physical Review Letters 119/19 2019-06-07
2018 Arnold Mathijssen, Nuris Figueroa-Morales, Gaspard Junot, Eric Clement, Anke Lindner, and Andreas Zöttl
Oscillatory surface rheotaxis of swimming E. coli bacteria
published pages: , ISSN: , DOI:
submitted to Physical Review Letters 2019-06-07

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The information about "GELSWIMMING" are provided by the European Opendata Portal: CORDIS opendata.

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