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ResonanceCircuits SIGNED

Illuminating neural microcircuitry underlying flicker resonance in the visual cortex

Total Cost €

0

EC-Contrib. €

0

Partnership

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 ResonanceCircuits project word cloud

Explore the words cloud of the ResonanceCircuits project. It provides you a very rough idea of what is the project "ResonanceCircuits" about.

gamma    neurosciences    entrained    manipulate    visual    mediate    interneuron    optogenetically    clinicians    became    spatial    engage    neurobiological    optogenetics    unknown    purkinje    light    underlying    10    local    perception    alpha    scientists    recording    almost    treatment    combine    modulate    engages    flickering    responds    examined    resonates    40    profile    uncover    aberrant    optogenetic    laminar    theta    multiple    cortex    interneurons    recordings    neurons    neuroscientists    rhythmic    200    tool    mice    cell    cortical    brain    gabaergic    simultaneous    types    20    fascinated    density    scales    rapid    diagnostic    rhythms    resonant    flicker    potentials    illusions    untapped    hz    awake    stimulation    classes    primary    accessible    neurophysiological    clinical    genetically    eeg    beta    decade    resonance    mechanisms    me    tools    artists    silencing    frequencies    layers    stimuli    basis    circuits    hypothesis    unprecedented    domain    entrains    span    jan    optical    neural    cognitive    ago   

Project "ResonanceCircuits" data sheet

The following table provides information about the project.

Coordinator
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW 

Organization address
address: KLOVENIERSBURGWAL 29 HET TRIPPENHUIS
city: AMSTERDAM
postcode: 1011 JV
website: www.knaw.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 175˙572 €
 EC max contribution 175˙572 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL (AMSTERDAM) coordinator 175˙572.00

Map

 Project objective

Almost 200 years ago, Jan Purkinje examined the visual illusions induced by flickering light. Since then, scientists, clinicians, and artists have been fascinated by the effects of flicker on brain rhythms. When entrained with rhythmic light of ~10, ~20, ~40 Hz, visual cortex responds more strongly, or resonates. In the visual and cognitive neurosciences, resonance flicker is used to study perception and attention; in clinical domain, aberrant resonance responses to flicker are used as a diagnostic tool and potential treatment. However, the neural mechanisms by which flicker engages resonant properties of local cortical circuits and entrains brain rhythms at the level they are generated remain unknown. Over the past decade, this level became accessible to neuroscientists due to the rapid development of new neurobiological tools such as cell-type-specific optical stimulation (optogenetics). In this project, using recordings that span multiple spatial scales (from neurons and local field potentials across cortical layers to EEG), I will characterize the neural mechanisms by which flicker stimuli engage resonant properties of brain rhythms. I will use optogenetic tools to identify and manipulate genetically targeted cell types, and will combine it with simultaneous EEG and high-density laminar recordings in primary visual cortex of awake mice. I will determine the laminar profile of neural activity underlying flicker resonance observed at the EEG level (Study 1). By recording from distinct GABAergic interneuron classes and optogenetically silencing them, I will test the novel hypothesis that distinct classes of interneurons mediate flicker resonance to low (theta, alpha) and high (beta, gamma) frequencies (Study 2). This research will allow me to uncover the neurophysiological basis of resonance responses to flicker in unprecedented detail, and provide means to exploit the untapped potential of flicker as a tool to study and modulate brain rhythms in a targeted way.

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The information about "RESONANCECIRCUITS" are provided by the European Opendata Portal: CORDIS opendata.

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