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CONSORT

Controlled Singlet Oxygen Release Photosensitizers in Photodynamic Therapy

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CONSORT" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://chemistry.tcd.ie/staff/people/mos/People/Mathias.html
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-15   to  2017-09-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

Photodynamic therapy is a form of phototherapy which uses light-sensitive compounds (photosensitizers) that are exposed selectively to light, whereupon they become toxic to targeted malignant and other diseased cells. The photosensitizer creates a highly reactive singlet oxygen species which rapidly reacts with any nearby biomolecules leading to destructive reactions resulting in cell death through apoptosis or necrosis. However, prolonged exposure of tissue to light irradiation causes photosensitivity in patients’ skin. Side effects may include, pain, burning/stinging sensation, itchiness. This proposal aims to develop a conceptually new approach towards photodynamic therapy through an introduction of new type of photosensitizers and corresponding nanomaterials which are capable to generate singlet oxygen upon irradiation, store it by means of binding to special molecular subunits and slowly release singlet oxygen within tissue on a timescale from several hours to several days after light irradiation treatment. The application of such novel material will allow for increasing therapeutic effect and reduced side-effects with respect to conventional PDT due to shorter light treatment duration. Proof of concept will be attained by demonstration of delayed singlet oxygen formation in cancer cells after the light treatment using in vitro models. The project builds on the strengths of the applicant in organic chemistry, photophysics and material science and combines these with new training in biomedicine and drug development to open a new research direction and to enhance cross-European collaboration.

 Publications

year authors and title journal last update
List of publications.
2017 Susan Callaghan, Mikhail A. Filatov, Elisabeth Sitte, Huguette Savoie, Ross W. Boyle, Keith J. Flanagan, Mathias O. Senge
Delayed release singlet oxygen sensitizers based on pyridone-appended porphyrins
published pages: 1371-1374, ISSN: 1474-905X, DOI: 10.1039/C7PP00244K
Photochem. Photobiol. Sci. 16/9 2019-07-23
2017 Mikhail A. Filatov, Safakath Karuthedath, Pavel M. Polestshuk, Huguette Savoie, Keith J. Flanagan, Cindy Sy, Elisabeth Sitte, Maxime Telitchko, Frédéric Laquai, Ross W. Boyle, Mathias O. Senge
Generation of Triplet Excited States via Photoinduced Electron Transfer in meso -anthra-BODIPY: Fluorogenic Response toward Singlet Oxygen in Solution and in Vitro
published pages: 6282-6285, ISSN: 0002-7863, DOI: 10.1021/jacs.7b00551
Journal of the American Chemical Society 139/18 2019-07-23
2016 Mikhail A. Filatov, Mathias O. Senge
Molecular devices based on reversible singlet oxygen binding in optical and photomedical applications
published pages: 258-272, ISSN: 2058-9689, DOI: 10.1039/C6ME00042H
Mol. Syst. Des. Eng. 1/3 2019-07-23
2016 Tiago Gualberto Bezera de Souza, Marcelo Gonçalves Vivas, Cleber Renato Mendonça, Shane Plunkett, Mikhail A. Filatov, Mathias O. Senge, Leonardo De Boni
Studying the intersystem crossing rate and triplet quantum yield of meso -substituted porphyrins by means of pulse train fluorescence technique
published pages: 282-291, ISSN: 1088-4246, DOI: 10.1142/S1088424616500048
Journal of Porphyrins and Phthalocyanines 20/01n04 2019-07-23

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