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miROMeS

miRNA biomarkers of Osseous Metastases in Serum from breast cancer patients

Total Cost €

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EC-Contrib. €

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Partnership

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Project "miROMeS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITE LYON 1 CLAUDE BERNARD 

Organization address
address: BOULEVARD DU 11 NOVEMBRE 1918 NUM43
city: VILLEURBANNE CEDEX
postcode: 69622
website: www.univ-Iyon1.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 185˙076 €
 EC max contribution 185˙076 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-09-20

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITE LYON 1 CLAUDE BERNARD FR (VILLEURBANNE CEDEX) coordinator 185˙076.00

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 Project objective

Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.

 Publications

year authors and title journal last update
List of publications.
2017 Caroline Reynaud, Laura Ferreras, Paola Di Mauro, Casina Kan, Martine Croset, Edith Bonnelye, Floriane Pez, Clémence Thomas, Géraldine Aimond, Antoine E. Karnoub, Marie Brevet, Philippe Clézardin
Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone
published pages: 268-278, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-15-2621
Cancer Research 77/2 2019-06-17
2016 Martine Croset, Francesco Pantano, Casina Kan, Edith Bonnelye, Françoise Descotes, Catherine Alix-Panabières, Charles Lecellier, Richard Bachelier, Nathalie Alioli, Saw See Hong, Kai Bartowiak, Klaus Pantel and Philippe Clézardin.
MicroRNA-30 Family Reduces Breast Cancer Bone Metastasis by Impairing Invasion, Osteomimicry and Bone Destruction
published pages: , ISSN: , DOI:
2019-06-17
2015 Anais Fradet, Mathilde Bouchet, Carine Delliaux, Manon Gervais, Casina Kan, Claire Benetollo, Francesco Pantano, Geoffrey Vargas, Lamia Bouazza, Martine Croset, Yohann Bala, xavier Leroy, Thomas J Rosol, Jennifer Rieusset, Akeila Bellahcène, Vincent Castronovo, Jane E Aubin, Philippe Clézardin, Martine Duterque-Coquillaud, Edith Bonnelye
Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.12787
Oncotarget 2019-06-17
2016 Casina Kan, Geoffrey Vargas, François Pape, Philippe Clézardin
Cancer Cell Colonisation in the Bone Microenvironment
published pages: 1674, ISSN: 1422-0067, DOI: 10.3390/ijms17101674
International Journal of Molecular Sciences 17/10 2019-06-17
2015 Croset M, Kan C, Clézardin P.
Tumour-derived miRNAs and bone metastasis.
published pages: 4:688, ISSN: , DOI: 10.1038/bonekey.215.56
BoneKey Reports 4 2019-06-17

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