Explore the words cloud of the miROMeS project. It provides you a very rough idea of what is the project "miROMeS" about.
The following table provides information about the project.
UNIVERSITE LYON 1 CLAUDE BERNARD
|Coordinator Country||France [FR]|
|Total cost||185˙076 €|
|EC max contribution||185˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-06-01 to 2017-09-20|
Take a look of project's partnership.
|1||UNIVERSITE LYON 1 CLAUDE BERNARD||FR (VILLEURBANNE CEDEX)||coordinator||185˙076.00|
Bone metastasis is a common complication for breast cancer patients, affecting 70% of patients diagnosed at advanced stages. Blood-based microRNAs (miRNAs) have received considerable research interest as biomarkers in cancer. The identification of biomarkers predictive of bone metastasis may be useful for the administration of preventative drugs such as bisphosphonates. In this study, a large-scale screening analysis of > 700 miRNAs will be performed in serum from breast cancer patients with and without visceral or bone metastasis. We will further evaluate candidate miRNAs using serum samples from a second cohort of breast cancer patients who were examined prospectively (with 8 years of follow-up) for relapses in bone and non-bone sites. At this stage, we anticipate the identification of a miRNA signature predictive of bone metastasis in patients with early-stage breast cancer. The second part of this study will assess the role of these miRNAs in the tumour-bone microenvironment. Circulating miRNAs may derive from bone cells or the tumour, and may enter the circulation through cell-derived vesicles called exosomes. We will study the biological functions of miRNAs dysregulated in patient serum. Overlaps between miRNAs in the serum and exosomal miRNAs that are derived from tumour cells or osteoclasts will be further assessed using in vitro and in vivo models of bone metastasis. By studying the activities of these exosomal miRNAs in the bone microenvironment, we may be able to better understand bone metastasis as well as identify new miRNA-based therapeutic targets.
|year||authors and title||journal||last update|
Caroline Reynaud, Laura Ferreras, Paola Di Mauro, Casina Kan, Martine Croset, Edith Bonnelye, Floriane Pez, ClÃ©mence Thomas, GÃ©raldine Aimond, Antoine E. Karnoub, Marie Brevet, Philippe ClÃ©zardin
Lysyl Oxidase Is a Strong Determinant of Tumor Cell Colonization in Bone
published pages: 268-278, ISSN: 0008-5472, DOI: 10.1158/0008-5472.CAN-15-2621
|Cancer Research 77/2||2019-06-17|
Martine Croset, Francesco Pantano, Casina Kan, Edith Bonnelye, FranÃ§oise Descotes, Catherine Alix-PanabiÃ¨res, Charles Lecellier, Richard Bachelier, Nathalie Alioli, Saw See Hong, Kai Bartowiak, Klaus Pantel and Philippe ClÃ©zardin.
MicroRNA-30 Family Reduces Breast Cancer Bone Metastasis by Impairing Invasion, Osteomimicry and Bone Destruction
published pages: , ISSN: , DOI:
Anais Fradet, Mathilde Bouchet, Carine Delliaux, Manon Gervais, Casina Kan, Claire Benetollo, Francesco Pantano, Geoffrey Vargas, Lamia Bouazza, Martine Croset, Yohann Bala, xavier Leroy, Thomas J Rosol, Jennifer Rieusset, Akeila BellahcÃ¨ne, Vincent Castronovo, Jane E Aubin, Philippe ClÃ©zardin, Martine Duterque-Coquillaud, Edith Bonnelye
Estrogen related receptor alpha in castration-resistant prostate cancer cells promotes tumor progression in bone
published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.12787
Casina Kan, Geoffrey Vargas, FranÃ§ois Pape, Philippe ClÃ©zardin
Cancer Cell Colonisation in the Bone Microenvironment
published pages: 1674, ISSN: 1422-0067, DOI: 10.3390/ijms17101674
|International Journal of Molecular Sciences 17/10||2019-06-17|
Croset M, Kan C, ClÃ©zardin P.
Tumour-derived miRNAs and bone metastasis.
published pages: 4:688, ISSN: , DOI: 10.1038/bonekey.215.56
|BoneKey Reports 4||2019-06-17|
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The information about "MIROMES" are provided by the European Opendata Portal: CORDIS opendata.
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