Opendata, web and dolomites


The evolutionary and ecological implications of mito-nuclear epistasis

Total Cost €


EC-Contrib. €






Project "MITONUC" data sheet

The following table provides information about the project.


Organization address
postcode: 751 05

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 185˙857 €
 EC max contribution 185˙857 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-10-01   to  2017-09-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UPPSALA UNIVERSITET SE (UPPSALA) coordinator 185˙857.00


 Project objective

The main hypothesis of the proposed research is that, contrary to common and long-standing belief, mitochondrial genetic variation is functional and plays a key role in evolutionary adaptation. I suggest that a novel understanding of selection on mtDNA can derive from simultaneously considering sex-specific selection and genetic interactions between mtDNA and nDNA. Because males are a genetic “dead-end” for mtDNA, mtDNA mutations that are detrimental for males but beneficial for females will spread. This will generate a male-specific genetic load (“the mother’s curse”). Further, the main energy producing pathway in eukaryotes (the OXPHOS pathway) is built collectively by products of the mitochondrial and the nuclear genome. Thus, mtDNA and nDNA are potentially entangled in an intricate web of epistatic interactions that dictates organismal metabolism. The proposed research is built upon a series of interrelated parts, and will use a very amenable insect model organism and employ a range of different research methodologies. Specific aims of the proposed research is (1) to assess the effects of mito-nuclear genotype on key life history traits such as metabolic rate and test whether these effects are sex-specific in line with the “mother’s curse” and (2) to test the hypothesis that mito-nuclear interactions promotes the maintenance of polymorphism in mitochondrial genome through negative frequency dependent selection. This research will have a range of biological implications, ranging from applied medical genetics over our use of mitochondrial genetic markers in population genetics/biology to speciation and our understanding of thermal adaptation to climate change.


year authors and title journal last update
List of publications.
2017 Marija Savic Veselinovic, Sofija Pavkovic-Lucic, Zorana Kurbalija Novicic, Mihailo Jelic, Marina Stamenkovic-Radak, Marko Andjelkovic
Mating behavior as an indicator of quality of Drosophila subobscura males?
published pages: 122-132, ISSN: 1672-9609, DOI: 10.1111/1744-7917.12257
Insect Science 24/1 2019-06-13
2016 Göran Arnqvist, Zorana Kurbalija Novičić, José A. Castro, Ahmed Sayadi
Negative frequency dependent selection on sympatric mtDNA haplotypes in Drosophila subobscura
published pages: 153: 15., ISSN: 1601-5223, DOI: 10.1186/s41065-016-0020-2
Hereditas 153/1 2019-06-13
2016 Marija Tanaskovic, Zorana Kurbalija-Novicic, Bojan Kenig, Savic Veselinovic, Marina Stamenkovic-Radak, Marko Andjelkovic
Synergistic effect of environmental and genomic stress on wing size of drosophila subobscura
published pages: 1039-1052, ISSN: 0534-0012, DOI: 10.2298/GENSR1603039T
Genetika 48/3 2019-06-13
2016 Cino Pertoldi, Simon Bahrndorff, Zorana Kurbalija Novicic, Palle Duun Rohde
The Novel Concept of “Behavioural Instability” and Its Potential Applications
published pages: 135, ISSN: 2073-8994, DOI: 10.3390/sym8110135
Symmetry 8/11 2019-06-13

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