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STROMAMECH

Targeting stromal cells to modify tumor mechanical microenvironment and optimize drug delivery

Total Cost €

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EC-Contrib. €

0

Partnership

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 STROMAMECH project word cloud

Explore the words cloud of the STROMAMECH project. It provides you a very rough idea of what is the project "STROMAMECH" about.

biophysics    pancreatic    progression    compressed    compression    cure    sufficient    techniques    computational    hypoperfused    solid    fibroblasts    vivo    judicious    edge    mice    tumour    cells    explore    levels    completion    ing    blood    maturity    negotiates    structure    subject    bidirectional    drastically    professional    therapeutic    validate    cafs    skills    stresses    expertise    employed    hypovascular    chemotherapeutic    stress    chemotherapies    desmoplastic    mechanical    scientific    efficacy    complete    accumulated    transfer    alleviation    types    nonetheless    treatment    proposes    strategy    vessels    biomechanical    insufficient    reopen    consequence    optimizes    drug    reveal    standard    training    cell    predictions    reaching    complemented    alleviate    performed    successful    reducing    primarily    amounts    breast    hypothesis    host    experimental    model    perfusion    cancer    cancers    degree    cutting    considerable    chemotherapy    never    society    contribution    transmission    attributed    vessel    kill    combination    depletion    agents    potent    forces    subsequently    current    generation    caf    tumours    mechanics    stromal   

Project "STROMAMECH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Project website http://www.ucy.ac.cy/cancer_biophysics/en/stromamech
 Total cost 151˙648 €
 EC max contribution 151˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 151˙648.00

Map

 Project objective

Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of standard chemotherapies for many cancer types (e.g., pancreatic and breast cancers) is primarily attributed to these agents never reaching cancer cells in amounts sufficient for complete cure. In solid tumours, blood vessels are often compressed, drastically reducing perfusion, thus resulting in insufficient drug delivery. Vessel compression is a consequence of mechanical stresses accumulated within the tumour during progression. Alleviation of these stresses has the potential to reopen compressed vessels and improve tumour perfusion. Here, the applicant proposes to test the hypothesis that judicious depletion of stromal cells, namely the cancer-associated fibroblasts (CAFs), has the potential to alleviate stress levels in highly desmoplastic and hypoperfused tumours and, thus, enhance chemotherapy. To explore this hypothesis, a combination of cutting-edge computational and experimental techniques will be employed. Specifically, a structure-based biomechanical model will be developed to analyse the contribution of CAFs to the generation and transmission of forces within a tumour. Subsequently, in vivo studies will be performed in mice to validate model predictions and identify the degree of CAF depletion that optimizes the efficacy of treatment. Successful completion of the proposed research will reveal the role of CAFs on the biomechanical behaviour of tumours and contribute to developing a therapeutic strategy for treatment of hypovascular tumours. Therefore, the proposal negotiates a subject of considerable importance for European society and beyond. Furthermore, the proposed research and training will establish a bidirectional transfer of skills where the applicant’s expertise in cell mechanics will be complemented by the Host’s in cancer biophysics, thus enhancing the applicant’s scientific potential and professional maturity, and promoting European research.

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The information about "STROMAMECH" are provided by the European Opendata Portal: CORDIS opendata.

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