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STROMAMECH

Targeting stromal cells to modify tumor mechanical microenvironment and optimize drug delivery

Total Cost €

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EC-Contrib. €

0

Partnership

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 STROMAMECH project word cloud

Explore the words cloud of the STROMAMECH project. It provides you a very rough idea of what is the project "STROMAMECH" about.

biophysics    edge    cure    types    vessels    model    techniques    vessel    pancreatic    strategy    subsequently    predictions    attributed    mechanical    breast    sufficient    considerable    reducing    validate    combination    completion    employed    mice    hypoperfused    cancers    stresses    blood    reopen    compressed    successful    society    transfer    expertise    never    hypothesis    depletion    cells    reveal    fibroblasts    contribution    experimental    drug    chemotherapies    performed    amounts    ing    stromal    negotiates    levels    drastically    agents    treatment    perfusion    transmission    vivo    alleviate    desmoplastic    generation    compression    bidirectional    structure    training    caf    maturity    reaching    primarily    explore    efficacy    chemotherapeutic    nonetheless    mechanics    cafs    proposes    professional    kill    chemotherapy    cancer    skills    biomechanical    standard    potent    therapeutic    forces    hypovascular    judicious    cutting    tumour    insufficient    subject    progression    cell    solid    scientific    consequence    tumours    host    current    degree    stress    computational    optimizes    accumulated    complemented    alleviation    complete   

Project "STROMAMECH" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF CYPRUS 

Organization address
address: KALLIPOLEOS STREET 75
city: NICOSIA
postcode: 1678
website: www.ucy.ac.cy

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Cyprus [CY]
 Project website http://www.ucy.ac.cy/cancer_biophysics/en/stromamech
 Total cost 151˙648 €
 EC max contribution 151˙648 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-05-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF CYPRUS CY (NICOSIA) coordinator 151˙648.00

Map

 Project objective

Current chemotherapeutic agents are potent enough to kill cancer cells. Nonetheless, failure of standard chemotherapies for many cancer types (e.g., pancreatic and breast cancers) is primarily attributed to these agents never reaching cancer cells in amounts sufficient for complete cure. In solid tumours, blood vessels are often compressed, drastically reducing perfusion, thus resulting in insufficient drug delivery. Vessel compression is a consequence of mechanical stresses accumulated within the tumour during progression. Alleviation of these stresses has the potential to reopen compressed vessels and improve tumour perfusion. Here, the applicant proposes to test the hypothesis that judicious depletion of stromal cells, namely the cancer-associated fibroblasts (CAFs), has the potential to alleviate stress levels in highly desmoplastic and hypoperfused tumours and, thus, enhance chemotherapy. To explore this hypothesis, a combination of cutting-edge computational and experimental techniques will be employed. Specifically, a structure-based biomechanical model will be developed to analyse the contribution of CAFs to the generation and transmission of forces within a tumour. Subsequently, in vivo studies will be performed in mice to validate model predictions and identify the degree of CAF depletion that optimizes the efficacy of treatment. Successful completion of the proposed research will reveal the role of CAFs on the biomechanical behaviour of tumours and contribute to developing a therapeutic strategy for treatment of hypovascular tumours. Therefore, the proposal negotiates a subject of considerable importance for European society and beyond. Furthermore, the proposed research and training will establish a bidirectional transfer of skills where the applicant’s expertise in cell mechanics will be complemented by the Host’s in cancer biophysics, thus enhancing the applicant’s scientific potential and professional maturity, and promoting European research.

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The information about "STROMAMECH" are provided by the European Opendata Portal: CORDIS opendata.

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