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SUSAMIDE

Sustainable Synthesis of Amides

Total Cost €

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EC-Contrib. €

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Partnership

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Project "SUSAMIDE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITEIT ANTWERPEN 

Organization address
address: PRINSSTRAAT 13
city: ANTWERPEN
postcode: 2000
website: www.ua.ac.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Project website https://www.facebook.com/groups/865354860229256/
 Total cost 172˙800 €
 EC max contribution 172˙800 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITEIT ANTWERPEN BE (ANTWERPEN) coordinator 172˙800.00

Map

 Project objective

Despite the ubiquity of the amide group, its synthesis is not always straightforward and the existing methods for amide formation score badly from the perspectives of economy and sustainability. This proposal aims to develop unprecedented methodology for amide synthesis, allowing one to access “challenging” representatives. Two routes are proposed to mitigate risk and to provide complementarity. The objective of the proposal is twofold: 1) to expand the available chemical space (allowing one to synthesize challenging amides previously considered inaccessible via library synthesis with existing methods) and 2) to substitute existing syntheses with better ones (delivering higher yields without using toxic reagents and minimizing waste). Achieving these two objectives will have an impact on the discovery of new molecular entities and the improvement of production processes in the fine chemicals sector. The power of the new methodology will be demonstrated on the synthesis of selected real-life examples, APIs (Active Pharmaceutical Ingredients).

 Publications

year authors and title journal last update
List of publications.
2016 Pieter Mampuys, Yanping Zhu, Sergey Sergeyev, Eelco Ruijter, Romano V. A. Orru, Sabine Van Doorslaer, Bert U. W. Maes
Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates
published pages: 2808-2811, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b01023
Organic Letters 18/12 2019-07-24
2016 Yan-Ping Zhu, Sergey Sergeyev, Philippe Franck, Romano V. A. Orru, Bert U. W. Maes
Amine Activation: Synthesis of N -(Hetero)arylamides from Isothioureas and Carboxylic Acids
published pages: 4602-4605, ISSN: 1523-7060, DOI: 10.1021/acs.orglett.6b02247
Organic Letters 18/18 2019-07-24

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