AND
Antibacterial (Nano)medicines Development
Total Cost €
0EC-Contrib. €
0Partnership
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0AND project word cloud
Explore the words cloud of the AND project. It provides you a very rough idea of what is the project "AND" about.
Project "AND" data sheet
The following table provides information about the project.
| Coordinator |
WAGENINGEN UNIVERSITY
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | https://www.wur.nl/en/project/Antibacterial-Nanomedicines-Development.htm |
| Total cost | 165˙598 € |
| EC max contribution | 165˙598 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2017-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | WAGENINGEN UNIVERSITY | NL (WAGENINGEN) | coordinator | 165˙598.00 |
Map
Project objective
Despite the investment of billions of euros, there has been an inexorable decline in the discovery of new antibiotics over the last decades. In this individual fellowship (IF) application we propose a strategy to develop bacterial histidine-kinase (HK) inhibitors targeted at the catalytic and ATP-biding domain (CA) as novel broad-spectrum antibacterial (nano)medicines. Furthermore, putative mechanism of resistance to HK inhibitors and known antibiotics will be studied and novel antibacterial drug targets will be identified by using transposon insertion mutant libraries (Tn-libraries) to identify mutations involved in intrinsic resistance to antibiotics and/or leading to increased sensitivity to existing antibiotics in multi-drug resistant (MDR) strains.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2016 |
Nadya Velikova, Kevin Kavanagh, Jerry M. Wells Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis published pages: , ISSN: 1471-2180, DOI: 10.1186/s12866-016-0905-2 |
BMC Microbiology 16/1 | 2019-07-24 |
| 2016 |
Nadya Velikova, Nuria Mas, Laura Miguel-Romero, Lorena Polo Aguado, Ellen Stolte, Edoardo Zaccaria, Rui Cao, Nico Taverne, José Ramón MurguÃa, Ramon Martinez-Manez, Alberto Marina, Jerry Wells Broadening the antibacterial spectrum of histidine kinase autophosphorylation inhibitors via the use of ε-poly-L-lysine capped mesoporous silica-based nanoparticles published pages: , ISSN: 1549-9634, DOI: 10.1016/j.nano.2016.09.011 |
Nanomedicine: Nanotechnology, Biology and Medicine | 2019-07-24 |
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