Opendata, web and dolomites

PERIF SIGNED

Perivascular cells at the crossroads of inflammation, regeneration and fibrosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 PERIF project word cloud

Explore the words cloud of the PERIF project. It provides you a very rough idea of what is the project "PERIF" about.

normal    scarring    usually    source    tumors    transiently    scleroderma    functional    organisms    medicine    beneficial    regulation    chronic    initially    fibrosis    agent    mural    diseases    preventing    identification    area    fibrotic    nearly    vessels    previously    biological    questions    vascular    tissues    roles    activation    function    wraps    profibrotic    mediators    collectively    tissue    avenues    cardiovascular    inappropriate    life    protective    relative    discrete    regulating    adult    fight    notable    disease    deaths    mechanisms    neutralize    mediated    birth    massive    point    team    contaminated    replaces    immune    fibrous    muscular    cells    injury    diversity    data    wound    survival    mesenchymal    threatening    heal    lung    paving    suggests    hindered    necrotic    dystrophies    variously    stromal    kidney    recovery    invaders    inflammation    eliminate    cancer    damaged    repair    scar    functions    intend    inflammatory    regeneration    partial    generating    therapeutic    population    world    bowel    pericytes    foreign    drew    harmful    half    excessive    injured    host    organ    liver    industrialized    unexpected    blood    settings    last    perivascular   

Project "PERIF" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙976˙100 €
 EC max contribution 1˙976˙100 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙976˙100.00

Map

 Project objective

The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a complex host response involving immune cells, blood vessels and inflammatory mediators that collectively intend to neutralize the harmful agent and eliminate damaged/necrotic tissue. Initially beneficial, this massive inflammatory response comes with a cost, and adult injured tissues usually heal with a scar, which is an area of fibrous tissue that transiently replaces normal tissue. In chronic settings, scarring can become excessive in a process called fibrosis, to the point of preventing functional recovery of the injured organ and be life threatening. Nearly half of all deaths in industrialized world are due to diseases involving inappropriate, often chronic, inflammatory and fibrotic responses, including lung, kidney and liver diseases, scleroderma, inflammatory bowel diseases, muscular dystrophies, cardiovascular diseases, and tumors. However our current knowledge of the biological processes regulating fibrosis is partial, which has hindered therapeutic advances in the field. Recent data from our team and others drew new attention on a discrete population of mesenchymal cells that wraps around vessels, variously called mural cells, perivascular cells or pericytes, as a major source for profibrotic stromal cells generating scar tissue. Previously known for their vascular protective functions, increasing evidence suggests new and unexpected roles for these cells also in inflammation, repair/regeneration, and cancer. These new findings raise a number of challenging questions relative to their functional diversity, as well as mechanisms of activation/ regulation in disease. The identification and specific targeting of functional subsets of mesenchymal perivascular cells may have notable impact in research and medicine, paving the way for new therapeutic avenues in inflammatory/fibrotic diseases and cancer.

 Publications

year authors and title journal last update
List of publications.
2018 Selene E. Di Carlo, Lucie Peduto
The perivascular origin of pathological fibroblasts
published pages: 54-63, ISSN: 0021-9738, DOI: 10.1172/JCI93558
Journal of Clinical Investigation 128/1 2019-07-25
2017 Igor Stzepourginski, Giulia Nigro, Jean-Marie Jacob, Sophie Dulauroy, Philippe J. Sansonetti, G?rard Eberl, Lucie Peduto
CD34 + mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury
published pages: E506-E513, ISSN: 0027-8424, DOI: 10.1073/pnas.1620059114
Proceedings of the National Academy of Sciences 114/4 2019-07-25

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "PERIF" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "PERIF" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

FatVirtualBiopsy (2020)

MRI toolkit for in vivo fat virtual biopsy

Read More  

BALANCED LETHALS (2019)

Untangling the Evolution of a Balanced Lethal System

Read More  

SECReTE (2018)

Enhancing biological drug production through protein secretion

Read More