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PERIF SIGNED

Perivascular cells at the crossroads of inflammation, regeneration and fibrosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PERIF project word cloud

Explore the words cloud of the PERIF project. It provides you a very rough idea of what is the project "PERIF" about.

adult    organisms    tumors    paving    heal    regulating    initially    medicine    profibrotic    avenues    blood    functional    usually    activation    mesenchymal    tissues    invaders    repair    regeneration    dystrophies    protective    relative    inappropriate    injury    damaged    disease    diversity    nearly    population    perivascular    muscular    mural    cardiovascular    inflammatory    partial    agent    mediated    fight    kidney    collectively    organ    scleroderma    fibrous    normal    unexpected    harmful    industrialized    survival    recovery    replaces    previously    regulation    scar    suggests    transiently    data    generating    team    necrotic    fibrosis    cancer    roles    mediators    contaminated    birth    vessels    threatening    vascular    preventing    half    inflammation    questions    injured    discrete    chronic    life    stromal    identification    bowel    function    cells    settings    lung    deaths    therapeutic    notable    wound    fibrotic    excessive    hindered    world    immune    massive    intend    pericytes    tissue    host    last    neutralize    biological    liver    eliminate    variously    beneficial    area    point    scarring    wraps    drew    functions    diseases    source    foreign    mechanisms   

Project "PERIF" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙976˙100 €
 EC max contribution 1˙976˙100 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙976˙100.00

Map

 Project objective

The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a complex host response involving immune cells, blood vessels and inflammatory mediators that collectively intend to neutralize the harmful agent and eliminate damaged/necrotic tissue. Initially beneficial, this massive inflammatory response comes with a cost, and adult injured tissues usually heal with a scar, which is an area of fibrous tissue that transiently replaces normal tissue. In chronic settings, scarring can become excessive in a process called fibrosis, to the point of preventing functional recovery of the injured organ and be life threatening. Nearly half of all deaths in industrialized world are due to diseases involving inappropriate, often chronic, inflammatory and fibrotic responses, including lung, kidney and liver diseases, scleroderma, inflammatory bowel diseases, muscular dystrophies, cardiovascular diseases, and tumors. However our current knowledge of the biological processes regulating fibrosis is partial, which has hindered therapeutic advances in the field. Recent data from our team and others drew new attention on a discrete population of mesenchymal cells that wraps around vessels, variously called mural cells, perivascular cells or pericytes, as a major source for profibrotic stromal cells generating scar tissue. Previously known for their vascular protective functions, increasing evidence suggests new and unexpected roles for these cells also in inflammation, repair/regeneration, and cancer. These new findings raise a number of challenging questions relative to their functional diversity, as well as mechanisms of activation/ regulation in disease. The identification and specific targeting of functional subsets of mesenchymal perivascular cells may have notable impact in research and medicine, paving the way for new therapeutic avenues in inflammatory/fibrotic diseases and cancer.

 Publications

year authors and title journal last update
List of publications.
2018 Selene E. Di Carlo, Lucie Peduto
The perivascular origin of pathological fibroblasts
published pages: 54-63, ISSN: 0021-9738, DOI: 10.1172/JCI93558
Journal of Clinical Investigation 128/1 2019-07-25
2017 Igor Stzepourginski, Giulia Nigro, Jean-Marie Jacob, Sophie Dulauroy, Philippe J. Sansonetti, G?rard Eberl, Lucie Peduto
CD34 + mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury
published pages: E506-E513, ISSN: 0027-8424, DOI: 10.1073/pnas.1620059114
Proceedings of the National Academy of Sciences 114/4 2019-07-25

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