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PERIF SIGNED

Perivascular cells at the crossroads of inflammation, regeneration and fibrosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 PERIF project word cloud

Explore the words cloud of the PERIF project. It provides you a very rough idea of what is the project "PERIF" about.

lung    deaths    population    paving    host    inflammation    area    function    notable    generating    stromal    discrete    settings    biological    liver    mechanisms    questions    fibrosis    partial    tissue    threatening    survival    repair    injury    inflammatory    fight    fibrous    blood    neutralize    intend    damaged    regulating    previously    variously    collectively    scarring    regulation    identification    organ    scleroderma    fibrotic    medicine    foreign    wraps    drew    recovery    mediated    cells    bowel    excessive    functional    life    profibrotic    hindered    adult    avenues    tissues    birth    functions    roles    wound    mural    injured    last    replaces    unexpected    normal    vascular    regeneration    kidney    chronic    muscular    industrialized    suggests    usually    data    mesenchymal    nearly    mediators    diversity    organisms    tumors    cardiovascular    eliminate    heal    perivascular    pericytes    necrotic    disease    transiently    activation    dystrophies    half    beneficial    immune    relative    initially    contaminated    vessels    therapeutic    point    world    protective    source    team    diseases    cancer    preventing    massive    inappropriate    harmful    scar    invaders    agent   

Project "PERIF" data sheet

The following table provides information about the project.

Coordinator
INSTITUT PASTEUR 

Organization address
address: RUE DU DOCTEUR ROUX 25-28
city: PARIS CEDEX 15
postcode: 75724
website: http://www.pasteur.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙976˙100 €
 EC max contribution 1˙976˙100 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-CoG
 Funding Scheme ERC-COG
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2021-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT PASTEUR FR (PARIS CEDEX 15) coordinator 1˙976˙100.00

Map

 Project objective

The survival of organisms requires the ability to repair tissues upon injury, as well as, after birth, to fight foreign invaders that may have contaminated the wound. This last function is mediated by a complex host response involving immune cells, blood vessels and inflammatory mediators that collectively intend to neutralize the harmful agent and eliminate damaged/necrotic tissue. Initially beneficial, this massive inflammatory response comes with a cost, and adult injured tissues usually heal with a scar, which is an area of fibrous tissue that transiently replaces normal tissue. In chronic settings, scarring can become excessive in a process called fibrosis, to the point of preventing functional recovery of the injured organ and be life threatening. Nearly half of all deaths in industrialized world are due to diseases involving inappropriate, often chronic, inflammatory and fibrotic responses, including lung, kidney and liver diseases, scleroderma, inflammatory bowel diseases, muscular dystrophies, cardiovascular diseases, and tumors. However our current knowledge of the biological processes regulating fibrosis is partial, which has hindered therapeutic advances in the field. Recent data from our team and others drew new attention on a discrete population of mesenchymal cells that wraps around vessels, variously called mural cells, perivascular cells or pericytes, as a major source for profibrotic stromal cells generating scar tissue. Previously known for their vascular protective functions, increasing evidence suggests new and unexpected roles for these cells also in inflammation, repair/regeneration, and cancer. These new findings raise a number of challenging questions relative to their functional diversity, as well as mechanisms of activation/ regulation in disease. The identification and specific targeting of functional subsets of mesenchymal perivascular cells may have notable impact in research and medicine, paving the way for new therapeutic avenues in inflammatory/fibrotic diseases and cancer.

 Publications

year authors and title journal last update
List of publications.
2018 Selene E. Di Carlo, Lucie Peduto
The perivascular origin of pathological fibroblasts
published pages: 54-63, ISSN: 0021-9738, DOI: 10.1172/JCI93558
Journal of Clinical Investigation 128/1 2019-07-25
2017 Igor Stzepourginski, Giulia Nigro, Jean-Marie Jacob, Sophie Dulauroy, Philippe J. Sansonetti, G?rard Eberl, Lucie Peduto
CD34 + mesenchymal cells are a major component of the intestinal stem cells niche at homeostasis and after injury
published pages: E506-E513, ISSN: 0027-8424, DOI: 10.1073/pnas.1620059114
Proceedings of the National Academy of Sciences 114/4 2019-07-25

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