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OLIGOBINPRO

Non-canonical nucleoside incorporation into synthetic RNA-oligonucleotides: investigations towards the discovery of selective RNA-binding proteins

Total Cost €

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EC-Contrib. €

0

Partnership

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 OLIGOBINPRO project word cloud

Explore the words cloud of the OLIGOBINPRO project. It provides you a very rough idea of what is the project "OLIGOBINPRO" about.

biology    spectrometric    society    tuning    mimicking    gene    mrna    discover    rna    ones    meet    unavoidable    embark    career    healthier    quality    human    extracts    expression    debilitating    amounts    inspire    cm    strands    eliminating    treatment    genes    responsibility    fine    interaction    care    cancer    academic    systematically    structure    binding    tune    responsible    incubating    biological    incorporated    difficulty    ms2i6a    money    i6a    obesity    linked    first    life    natural    prevention    innovative    proteins    aforementioned    michaelides    training    cell    prevent    modified    therapies    occurrence    analysing    oligoribonucleotides    sustained    vast    world    gm    patients    plethora    treating    techniques    tagging    bottleneck    oligoribonucleotide    diseases    neurological    multidisciplinary    parkinson    canonical    chemistry    lines    possibility    synthesised    regulates    mass    bind    am    scientists    subsequently    cellular    exposing    expectancy    chemical    mechanisms    synthesis    modifications    translation    technologies    dr    foundation   

Project "OLIGOBINPRO" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

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 Project objective

The increase of life expectancy around the world comes at the unavoidable cost of a rise in the occurrence of neurological diseases such as Parkinson’s as well as debilitating ones like cancer. These conditions prevent the possibility of a sustained quality of life and cost society vast amounts of money for the treatment and care of patients. It is the responsibility of scientists to find innovative methods of treating and eliminating these diseases, allowing for a healthier quality of life. Recently, RNA-binding proteins have been linked to biological processes leading to these diseases as well as the expression of genes relating to obesity. A plethora of natural chemical modifications in RNA fine-tune its structure, allowing for this specific interaction which regulates processes such as gene expression and the tuning of translation. Although these have been known for years, their binding proteins have not been systematically studied. The difficulty of the chemical synthesis of modified oligoribonucleotides represents the major bottleneck in this field. The overall aim of this project is to discover RNA-binding proteins which bind to the non-canonical modifications Am, Cm, Gm, i6A and ms2i6A which were identified in the mRNA of human cancer cell lines. These will first be synthesised and then incorporated into oligoribonucleotide strands mimicking natural mRNA. By incubating with cellular extracts, we subsequently aim to identify their binding proteins by tagging them with novel technologies and analysing them using mass spectrometric techniques. This project will inspire and offer unique training to Dr. Michaelides by exposing him to this multidisciplinary field where chemistry and biology meet, enabling him to embark on his own academic career. Furthermore, it will set the foundation for the better understanding of the mechanisms responsible for the aforementioned conditions, which will in the long term lead to the design of new therapies for their prevention.

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The information about "OLIGOBINPRO" are provided by the European Opendata Portal: CORDIS opendata.

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