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OLIGOBINPRO

Non-canonical nucleoside incorporation into synthetic RNA-oligonucleotides: investigations towards the discovery of selective RNA-binding proteins

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 OLIGOBINPRO project word cloud

Explore the words cloud of the OLIGOBINPRO project. It provides you a very rough idea of what is the project "OLIGOBINPRO" about.

oligoribonucleotides    am    gm    world    systematically    life    quality    multidisciplinary    canonical    cancer    chemical    healthier    occurrence    linked    synthesised    embark    ms2i6a    dr    vast    ones    modified    sustained    incubating    prevent    academic    prevention    genes    analysing    meet    biological    biology    inspire    care    exposing    tune    structure    technologies    money    obesity    expression    translation    possibility    scientists    chemistry    expectancy    training    diseases    spectrometric    fine    cm    difficulty    extracts    natural    aforementioned    unavoidable    patients    first    treating    cellular    career    therapies    michaelides    cell    responsibility    plethora    tuning    neurological    foundation    gene    i6a    lines    parkinson    subsequently    synthesis    mass    tagging    discover    mechanisms    regulates    amounts    strands    eliminating    treatment    interaction    modifications    proteins    oligoribonucleotide    bottleneck    bind    binding    innovative    incorporated    debilitating    human    mrna    rna    society    mimicking    techniques    responsible   

Project "OLIGOBINPRO" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

The increase of life expectancy around the world comes at the unavoidable cost of a rise in the occurrence of neurological diseases such as Parkinson’s as well as debilitating ones like cancer. These conditions prevent the possibility of a sustained quality of life and cost society vast amounts of money for the treatment and care of patients. It is the responsibility of scientists to find innovative methods of treating and eliminating these diseases, allowing for a healthier quality of life. Recently, RNA-binding proteins have been linked to biological processes leading to these diseases as well as the expression of genes relating to obesity. A plethora of natural chemical modifications in RNA fine-tune its structure, allowing for this specific interaction which regulates processes such as gene expression and the tuning of translation. Although these have been known for years, their binding proteins have not been systematically studied. The difficulty of the chemical synthesis of modified oligoribonucleotides represents the major bottleneck in this field. The overall aim of this project is to discover RNA-binding proteins which bind to the non-canonical modifications Am, Cm, Gm, i6A and ms2i6A which were identified in the mRNA of human cancer cell lines. These will first be synthesised and then incorporated into oligoribonucleotide strands mimicking natural mRNA. By incubating with cellular extracts, we subsequently aim to identify their binding proteins by tagging them with novel technologies and analysing them using mass spectrometric techniques. This project will inspire and offer unique training to Dr. Michaelides by exposing him to this multidisciplinary field where chemistry and biology meet, enabling him to embark on his own academic career. Furthermore, it will set the foundation for the better understanding of the mechanisms responsible for the aforementioned conditions, which will in the long term lead to the design of new therapies for their prevention.

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The information about "OLIGOBINPRO" are provided by the European Opendata Portal: CORDIS opendata.

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