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OLIGOBINPRO

Non-canonical nucleoside incorporation into synthetic RNA-oligonucleotides: investigations towards the discovery of selective RNA-binding proteins

Total Cost €

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EC-Contrib. €

0

Partnership

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 OLIGOBINPRO project word cloud

Explore the words cloud of the OLIGOBINPRO project. It provides you a very rough idea of what is the project "OLIGOBINPRO" about.

tagging    rna    mimicking    proteins    oligoribonucleotides    gm    responsible    expectancy    translation    modifications    prevent    mass    modified    genes    mrna    lines    treatment    technologies    inspire    i6a    gene    sustained    life    mechanisms    money    synthesised    synthesis    oligoribonucleotide    exposing    debilitating    systematically    linked    amounts    embark    training    ones    extracts    ms2i6a    chemistry    eliminating    plethora    quality    multidisciplinary    cellular    discover    treating    healthier    cell    am    biological    subsequently    cancer    michaelides    occurrence    patients    tune    strands    first    natural    analysing    parkinson    society    bottleneck    therapies    meet    canonical    spectrometric    diseases    incorporated    possibility    difficulty    innovative    incubating    interaction    cm    fine    academic    career    obesity    world    expression    prevention    techniques    structure    biology    tuning    bind    aforementioned    unavoidable    care    scientists    chemical    regulates    human    foundation    binding    dr    neurological    responsibility    vast   

Project "OLIGOBINPRO" data sheet

The following table provides information about the project.

Coordinator
LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN 

Organization address
address: GESCHWISTER SCHOLL PLATZ 1
city: MUENCHEN
postcode: 80539
website: www.uni-muenchen.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 159˙460 €
 EC max contribution 159˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-06-01   to  2017-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) coordinator 159˙460.00

Map

 Project objective

The increase of life expectancy around the world comes at the unavoidable cost of a rise in the occurrence of neurological diseases such as Parkinson’s as well as debilitating ones like cancer. These conditions prevent the possibility of a sustained quality of life and cost society vast amounts of money for the treatment and care of patients. It is the responsibility of scientists to find innovative methods of treating and eliminating these diseases, allowing for a healthier quality of life. Recently, RNA-binding proteins have been linked to biological processes leading to these diseases as well as the expression of genes relating to obesity. A plethora of natural chemical modifications in RNA fine-tune its structure, allowing for this specific interaction which regulates processes such as gene expression and the tuning of translation. Although these have been known for years, their binding proteins have not been systematically studied. The difficulty of the chemical synthesis of modified oligoribonucleotides represents the major bottleneck in this field. The overall aim of this project is to discover RNA-binding proteins which bind to the non-canonical modifications Am, Cm, Gm, i6A and ms2i6A which were identified in the mRNA of human cancer cell lines. These will first be synthesised and then incorporated into oligoribonucleotide strands mimicking natural mRNA. By incubating with cellular extracts, we subsequently aim to identify their binding proteins by tagging them with novel technologies and analysing them using mass spectrometric techniques. This project will inspire and offer unique training to Dr. Michaelides by exposing him to this multidisciplinary field where chemistry and biology meet, enabling him to embark on his own academic career. Furthermore, it will set the foundation for the better understanding of the mechanisms responsible for the aforementioned conditions, which will in the long term lead to the design of new therapies for their prevention.

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The information about "OLIGOBINPRO" are provided by the European Opendata Portal: CORDIS opendata.

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