Explore the words cloud of the nAChR PAM-to-gate project. It provides you a very rough idea of what is the project "nAChR PAM-to-gate" about.
The following table provides information about the project.
|Coordinator Country||France [FR]|
|Total cost||185˙076 €|
|EC max contribution||185˙076 € (100%)|
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
|Duration (year-month-day)||from 2015-04-01 to 2017-03-31|
Take a look of project's partnership.
|1||INSTITUT PASTEUR||FR (PARIS CEDEX 15)||coordinator||185˙076.00|
Pentameric ligand-gated ion channels (pLGICs), including nicotinic acetylcholine, 5HT3, glycine, and GABAA receptors, are membrane proteins specialized in the communication between neurons. These neurotransmitter receptors are the target of general anaesthetics, anxiolytics, alcohols and nicotine. In particular, enhancing the activity of neuronal nicotinic receptors holds promises in the treatment of pathologies including nicotine addiction, schizophrenia and Alzheimer’s disease. The current project aims at deciphering the molecular and pharmacological determinants of positive allosteric modulators of neuronal nicotinic receptors. We will over-express and purify these proteins, study their pharmacology through electrophysiology in cell lines and planar lipid bilayer, and surface plasmon resonance binding studies. Our study will provide insights into the molecular mechanisms of allosteric regulation, paving the way for the rational design of allosteric modulators with therapeutic potential.
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