Opendata, web and dolomites

MatrixMacrophages SIGNED

Matrix degrading macrophages in cancer growth and invasion

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "MatrixMacrophages" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Project website http://www.bric.ku.dk/Research/behrendt_group/
 Total cost 212˙194 €
 EC max contribution 212˙194 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-07-01   to  2017-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 212˙194.00

Map

 Project objective

Solid tumors consist of malignant cancer cells in constant interaction with the extracellular matrix and different types of non-malignant cells. Notably, these cells include macrophages which, during cancer progression, take part in an extensive degradation of the extracellular matrix. This process leads to destruction of the normal tissue and facilitates metastatic spread. It is now evident that tumor-infiltrating macrophages have a strong impact on cancer progression and this has led to the suggestion that therapeutic targeting of these cells could form the basis of a powerful new type of cancer treatment. However, there is a strong need for increased understanding of the function of these tumor-associated macrophages in order to optimize the development of such new therapy. Most importantly, different subtypes of macrophages exist, but how these subtypes affect cancer progression and whether they contribute to the cancer-associated extracellular matrix degradation is very incompletely understood. In this proposed project I aim to elucidate the exact role of different subtypes of macrophages for cancer progression and for the accompanying extracellular matrix degradation. By using several experimental state-of-the-art techniques, I will directly examine the effect of different subtypes of macrophages on cancer growth and invasion. These techniques include two-photon microscopy, flow cytometry based cell sorting, next-generation sequencing, cell biology assays, and mouse genetic engineering. In particular, I am currently developing transgenic mice that allow both the visualization of specific macrophage subsets using fluorescence microscopy and the specific depletion of these cell populations. When combined with tumor models, these mice will provide unique insight about the importance of the cell types in question. The study will add significantly to our knowledge about macrophages in cancer biology and aid in the development of new cancer therapy strategies.

 Publications

year authors and title journal last update
List of publications.
2016 M. P. Motley, D. H. Madsen, H. J. Jurgensen, D. E. Spencer, R. Szabo, K. Holmbeck, M. J. Flick, D. A. Lawrence, F. J. Castellino, R. Weigert, T. H. Bugge
A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo
published pages: 1085-1096, ISSN: 0006-4971, DOI: 10.1182/blood-2015-05-644260
Blood 127/9 2019-06-18
2016 Lars H Engelholm, Maria C Melander, Andreas Hald, Morten Persson, Daniel H Madsen, Henrik J Jürgensen, Kristina Johansson, Christoffer Nielsen, Kirstine S Nørregaard, Signe Z Ingvarsen, Andreas Kjaer, Clement S Trovik, Ole D Laerum, Thomas H Bugge, Johan Eide, Niels Behrendt
Targeting a novel bone degradation pathway in primary bone cancer by inactivation of the collagen receptor uPARAP/Endo180
published pages: 120-133, ISSN: 0022-3417, DOI: 10.1002/path.4661
The Journal of Pathology 238/1 2019-06-18
2017 Kuczek, D.E., Hübbe, M.L., Madsen, D.H.
Internalization of collagen: an important matrix turnover pathway in cancer
published pages: , ISSN: , DOI:
Extracellular matrix in tumor biology 2019-06-18
2016 Stine Friis, Daniel H. Madsen, Thomas H. Bugge
Distinct Developmental Functions of Prostasin (CAP1/PRSS8) Zymogen and Activated Prostasin
published pages: 2577-2582, ISSN: 0021-9258, DOI: 10.1074/jbc.C115.706721
Journal of Biological Chemistry 291/6 2019-06-18
2016 Ming-Hui Fan, Qiang Zhu, Hui-Hua Li, Hyun-Jeong Ra, Sonali Majumdar, Dexter L. Gulick, Jacob A. Jerome, Daniel H. Madsen, Melpo Christofidou-Solomidou, David W. Speicher, William W. Bachovchin, Carol Feghali-Bostwick, Ellen Puré
Fibroblast Activation Protein (FAP) Accelerates Collagen Degradation and Clearance from Lungs in Mice
published pages: 8070-8089, ISSN: 0021-9258, DOI: 10.1074/jbc.M115.701433
Journal of Biological Chemistry 291/15 2019-06-18

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MATRIXMACROPHAGES" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MATRIXMACROPHAGES" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

InvADeRS (2019)

Investigating the Activity of transposon Derived Regulatory Sequences in the placenta

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More