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Amygdala Circuits SIGNED

Amygdala Circuits for Appetitive Conditioning

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EC-Contrib. €

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Project "Amygdala Circuits" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION 

Organization address
address: MAULBEERSTRASSE 66
city: BASEL
postcode: 4058
website: www.fmi.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 2˙497˙200 €
 EC max contribution 2˙497˙200 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2020-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) coordinator 2˙497˙200.00

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 Project objective

The project outlined here addresses the fundamental question how the brain encodes and controls behavior. While we have a reasonable understanding of the role of entire brain areas in such processes, and of mechanisms at the molecular and synaptic levels, there is a big gap in our knowledge of how behavior is controlled at the level of defined neuronal circuits.

In natural environments, chances for survival depend on learning about possible aversive and appetitive outcomes and on the appropriate behavioral responses. Most studies addressing the underlying mechanisms at the level of neuronal circuits have focused on aversive learning, such as in Pavlovian fear conditioning. Understanding how activity in defined neuronal circuits mediates appetitive learning, as well as how these circuitries are shared and interact with aversive learning circuits, is a central question in the neuroscience of learning and memory and the focus of this grant application.

Using a multidisciplinary approach in mice, combining behavioral, in vivo and in vitro electrophysiological, imaging, optogenetic and state-of-the-art viral circuit tracing techniques, we aim at dissecting the neuronal circuitry of appetitive Pavlovian conditioning with a focus on the amygdala, a key brain region important for both aversive and appetitive learning. Ultimately, elucidating these mechanisms at the level of defined neurons and circuits is fundamental not only for an understanding of memory processes in the brain in general, but also to inform a mechanistic approach to psychiatric conditions associated with amygdala dysfunction and dysregulated emotional responses including anxiety and mood disorders.

 Publications

year authors and title journal last update
List of publications.
2016 Elisabeth Vogel, Sabine Krabbe, Jan Gründemann, Jaclyn I. Wamsteeker Cusulin, Andreas Lüthi
Projection-Specific Dynamic Regulation of Inhibition in Amygdala Micro-Circuits
published pages: 644-651, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2016.06.036
Neuron 91/3 2019-07-04
2016 Chun Xu, Sabine Krabbe, Jan Gründemann, Paolo Botta, Jonathan P. Fadok, Fumitaka Osakada, Dieter Saur, Benjamin F. Grewe, Mark J. Schnitzer, Edward M. Callaway, Andreas Lüthi
Distinct Hippocampal Pathways Mediate Dissociable Roles of Context in Memory Retrieval
published pages: 961-972.e16, ISSN: 0092-8674, DOI: 10.1016/j.cell.2016.09.051
Cell 167/4 2019-07-04
2017 Jonathan P. Fadok, Sabine Krabbe, Milica Markovic, Julien Courtin, Chun Xu, Lema Massi, Paolo Botta, Kristine Bylund, Christian Müller, Aleksandar Kovacevic, Philip Tovote, Andreas Lüthi
A competitive inhibitory circuit for selection of active and passive fear responses
published pages: 96-100, ISSN: 0028-0836, DOI: 10.1038/nature21047
Nature 542/7639 2019-07-04
2018 Karen Lavi, Gilad A. Jacobson, Kobi Rosenblum, Andreas Lüthi
Encoding of Conditioned Taste Aversion in Cortico-Amygdala Circuits
published pages: 278-283, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.06.053
Cell Reports 24/2 2019-07-04
2017 Benjamin F. Grewe, Jan Gründemann, Lacey J. Kitch, Jerome A. Lecoq, Jones G. Parker, Jesse D. Marshall, Margaret C. Larkin, Pablo E. Jercog, Francois Grenier, Jin Zhong Li, Andreas Lüthi, Mark J. Schnitzer
Neural ensemble dynamics underlying a long-term associative memory
published pages: 670-675, ISSN: 0028-0836, DOI: 10.1038/nature21682
Nature 543/7647 2019-07-04
2018 Sabine Krabbe, Jan Gründemann, Andreas Lüthi
Amygdala Inhibitory Circuits Regulate Associative Fear Conditioning
published pages: 800-809, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2017.10.006
Biological Psychiatry 83/10 2019-07-04
2018 Jonathan P Fadok, Milica Markovic, Philip Tovote, Andreas Lüthi
New perspectives on central amygdala function
published pages: 141-147, ISSN: 0959-4388, DOI: 10.1016/j.conb.2018.02.009
Current Opinion in Neurobiology 49 2019-03-18

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