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ACM

Cholesterol metabolism as a driver of prostate cancer aggressiveness

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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0

 ACM project word cloud

Explore the words cloud of the ACM project. It provides you a very rough idea of what is the project "ACM" about.

cellular    survive    critical    disease    cic    mouse    indicating    resistance    fraction    metabolomic    tumors    treatment    metabolism    entities    retain    statin    hostile    reprogramming    associative    lifestyle    metastasis    obesity    according    notion    synthesis    cancers    subpopulation    patients    aggressive    inhibitors    men    reduces    accounts    supports    differential    regulates    environment    environmental    prostate    onset    sphere    active    therapy    therapeutic    20    alterations    dependent    lab    cholesterol    transformation    self    implication    capability    insufficient    preliminary    combined    prospective    renewal    rates    hypothesize    risk    metabolic    recurrence    cancer    enriched    view    mechanisms    capacity    population    pca    feasibility    nutrition    genes    transcriptomic    overweight    respectively    homogeneous    cells    model    death    cics    expression    prevention    cell    progression    markers    statins    function    undergo    union    initiating    tumor    stem    indicate   

Project "ACM" data sheet

The following table provides information about the project.

Coordinator
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS 

Organization address
address: PARQUE TECNOLOGICO EDIFICIO 801 A
city: DERIO VIZCAYA
postcode: 48160
website: www.cicbiogune.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website https://www.cicbiogune.es/
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) coordinator 158˙121.00

Map

 Project objective

According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The current view of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolic reprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retain a differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts for recurrence and resistance to therapy. While we know more about the metabolism of tumor cells and its implication in cancer, our knowledge about the metabolism of cancer-initiating cells remains insufficient. Obesity is associated with increased risk of prostate cancer metastasis and death. On other side, statins treatment reduces the risk of PCa, indicating that cholesterol might have a role in the onset of the disease. Overweight and obesity rates in EU affect 50 and 20% of the population respectively. Therefore, it is critical to define the role of environmental factors such as nutrition and “lifestyle” for cancer prevention. Preliminary studies in our lab indicate that cancer initiating cells are highly enriched in cholesterol synthesis genes and their sphere formation capacity is dependent on cholesterol synthesis. We hypothesize that an active cholesterol metabolism is essential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells. I will use a combined transcriptomic and metabolomic approach to define the alterations of cholesterol metabolism. I will study the mechanisms by which cholesterol metabolism regulates CIC function. I will study the feasibility of therapeutic targeting of cholesterol metabolism in prostate cancer using a well established mouse model. And finally, I will do a prospective associative study of statin treatment with CICs markers expression in patients.

 Publications

year authors and title journal last update
List of publications.
2017 Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez- Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita A, Muñoz J, Falcon-Perez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
published pages: , ISSN: , DOI: 10.1038/nature22964
2019-07-24
2015 Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. J Immunol.
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF
published pages: , ISSN: , DOI: 10.4049/jimmunol
2019-07-24
2016 Veronica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zúñiga-García, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia Martín-Martín, James David Sutherland, Pilar Sanchez-Mosquera, Laura Bozal-Basterra, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana Maria Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, Jason W. Locasale, Roger R. Gomis, Arkaitz Carracedo
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
published pages: 645-656, ISSN: 1465-7392, DOI: 10.1038/ncb3357
Nature Cell Biology 18/6 2019-07-24
2015 Ugalde-Olano A, Egia A, Fernández-Ruiz S, Loizaga-Iriarte A4, Zuñiga-García P, Garcia S, Royo F, Lacasa-Viscasillas I, Castro E, Cortazar AR, Zabala-Letona A, Martín-Martín N, Arruabarrena-Aristorena A, Torrano-Moya V, Valcárcel-Jiménez L, Sánchez-Mosquera P, Caro-Maldonado A, González-Tampan J, Cachi-Fuentes G, Bilbao E, Montero R, Fernández S, Arrieta E, Zorroza K, Castillo-Martín M, Serra V, Salazar E, Macías-Cámara N, Tabernero J, Baselga J, Cordón-Cardo C, Aransay AM, Villar AD, Iovanna JL, Falcón-Pérez JM, Unda M, Bilbao R, Carracedo A
Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN
published pages: , ISSN: , DOI: 10.1016/j.ymeth
2019-07-24

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