ACM
Cholesterol metabolism as a driver of prostate cancer aggressiveness
Total Cost €
0EC-Contrib. €
0Partnership
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Project "ACM" data sheet
The following table provides information about the project.
| Coordinator |
ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | https://www.cicbiogune.es/ |
| Total cost | 158˙121 € |
| EC max contribution | 158˙121 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2017-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS | ES (DERIO VIZCAYA) | coordinator | 158˙121.00 |
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Project objective
According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The current view of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolic reprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retain a differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts for recurrence and resistance to therapy. While we know more about the metabolism of tumor cells and its implication in cancer, our knowledge about the metabolism of cancer-initiating cells remains insufficient. Obesity is associated with increased risk of prostate cancer metastasis and death. On other side, statins treatment reduces the risk of PCa, indicating that cholesterol might have a role in the onset of the disease. Overweight and obesity rates in EU affect 50 and 20% of the population respectively. Therefore, it is critical to define the role of environmental factors such as nutrition and “lifestyle” for cancer prevention. Preliminary studies in our lab indicate that cancer initiating cells are highly enriched in cholesterol synthesis genes and their sphere formation capacity is dependent on cholesterol synthesis. We hypothesize that an active cholesterol metabolism is essential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells. I will use a combined transcriptomic and metabolomic approach to define the alterations of cholesterol metabolism. I will study the mechanisms by which cholesterol metabolism regulates CIC function. I will study the feasibility of therapeutic targeting of cholesterol metabolism in prostate cancer using a well established mouse model. And finally, I will do a prospective associative study of statin treatment with CICs markers expression in patients.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Zabala-Letona A, Arruabarrena-Aristorena A, MartÃn-MartÃn N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez- Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-GarcÃa P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-MartÃn M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farrà s R, Olmos D, Efeyan A, Anguita A, Muñoz J, Falcon-Perez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer published pages: , ISSN: , DOI: 10.1038/nature22964 |
2019-07-24 | |
| 2015 |
Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. J Immunol. IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF published pages: , ISSN: , DOI: 10.4049/jimmunol |
2019-07-24 | |
| 2016 |
Veronica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zúñiga-GarcÃa, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia MartÃn-MartÃn, James David Sutherland, Pilar Sanchez-Mosquera, Laura Bozal-Basterra, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana Maria Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, Jason W. Locasale, Roger R. Gomis, Arkaitz Carracedo The metabolic co-regulator PGC1α suppresses prostate cancer metastasis published pages: 645-656, ISSN: 1465-7392, DOI: 10.1038/ncb3357 |
Nature Cell Biology 18/6 | 2019-07-24 |
| 2015 |
Ugalde-Olano A, Egia A, Fernández-Ruiz S, Loizaga-Iriarte A4, Zuñiga-GarcÃa P, Garcia S, Royo F, Lacasa-Viscasillas I, Castro E, Cortazar AR, Zabala-Letona A, MartÃn-MartÃn N, Arruabarrena-Aristorena A, Torrano-Moya V, Valcárcel-Jiménez L, Sánchez-Mosquera P, Caro-Maldonado A, González-Tampan J, Cachi-Fuentes G, Bilbao E, Montero R, Fernández S, Arrieta E, Zorroza K, Castillo-MartÃn M, Serra V, Salazar E, MacÃas-Cámara N, Tabernero J, Baselga J, Cordón-Cardo C, Aransay AM, Villar AD, Iovanna JL, Falcón-Pérez JM, Unda M, Bilbao R, Carracedo A Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN published pages: , ISSN: , DOI: 10.1016/j.ymeth |
2019-07-24 |
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