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Cholesterol metabolism as a driver of prostate cancer aggressiveness

Total Cost €


EC-Contrib. €






 ACM project word cloud

Explore the words cloud of the ACM project. It provides you a very rough idea of what is the project "ACM" about.

alterations    resistance    transcriptomic    lab    lifestyle    associative    environmental    indicating    cancer    according    cells    men    view    capability    tumors    reprogramming    respectively    expression    hypothesize    death    active    supports    metastasis    union    fraction    insufficient    metabolic    metabolism    environment    prostate    nutrition    overweight    therapeutic    cholesterol    entities    implication    enriched    sphere    indicate    regulates    transformation    metabolomic    cics    tumor    obesity    function    capacity    mouse    disease    subpopulation    accounts    critical    risk    survive    combined    undergo    cellular    statin    treatment    mechanisms    pca    therapy    feasibility    cell    synthesis    hostile    differential    notion    rates    genes    homogeneous    prevention    self    patients    cic    retain    statins    stem    reduces    model    onset    cancers    20    population    preliminary    dependent    initiating    aggressive    prospective    renewal    markers    recurrence    progression    inhibitors   

Project "ACM" data sheet

The following table provides information about the project.


Organization address
postcode: 48160

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Project website
 Total cost 158˙121 €
 EC max contribution 158˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2015
 Duration (year-month-day) from 2015-04-01   to  2017-03-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

According to the WHO, prostate cancer (PCa) is the most common cancer in men in the European Union (EU). The current view of cellular transformation and cancer progression supports the notion that cancer cells must undergo a metabolic reprogramming in order to survive in a hostile environment. Tumors are not homogeneous entities, and most cancers retain a differential fraction of cells with increased self-renewal capability (cancer stem or initiating cells), that accounts for recurrence and resistance to therapy. While we know more about the metabolism of tumor cells and its implication in cancer, our knowledge about the metabolism of cancer-initiating cells remains insufficient. Obesity is associated with increased risk of prostate cancer metastasis and death. On other side, statins treatment reduces the risk of PCa, indicating that cholesterol might have a role in the onset of the disease. Overweight and obesity rates in EU affect 50 and 20% of the population respectively. Therefore, it is critical to define the role of environmental factors such as nutrition and “lifestyle” for cancer prevention. Preliminary studies in our lab indicate that cancer initiating cells are highly enriched in cholesterol synthesis genes and their sphere formation capacity is dependent on cholesterol synthesis. We hypothesize that an active cholesterol metabolism is essential for prostate cancer-initiating cell function, and that the use of cholesterol synthesis inhibitors might target this subpopulation of aggressive cancer cells. I will use a combined transcriptomic and metabolomic approach to define the alterations of cholesterol metabolism. I will study the mechanisms by which cholesterol metabolism regulates CIC function. I will study the feasibility of therapeutic targeting of cholesterol metabolism in prostate cancer using a well established mouse model. And finally, I will do a prospective associative study of statin treatment with CICs markers expression in patients.


year authors and title journal last update
List of publications.
2017 Zabala-Letona A, Arruabarrena-Aristorena A, Martín-Martín N, Fernandez-Ruiz S, Sutherland JD, Clasquin M, Tomas-Cortazar J, Jimenez J, Torres I, Quang P, Ximenez- Embun P, Bago R, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Torrano V, Cabrera D, van Liempd SM, Cendon Y, Castro E, Murray S, Revandkar A, Alimonti A, Zhang Y, Barnett A, Lein G, Pirman D, Cortazar AR, Arreal L, Prudkin L, Astobiza I, Valcarcel-Jimenez L, Zuñiga-García P, Fernandez-Dominguez I, Piva M, Caro-Maldonado A, Sánchez-Mosquera P, Castillo-Martín M, Serra V, Beraza N, Gentilella A, Thomas G, Azkargorta M, Elortza F, Farràs R, Olmos D, Efeyan A, Anguita A, Muñoz J, Falcon-Perez JM, Barrio R, Macarulla T, Mato JM, Martinez-Chantar ML, Cordon-Cardo C, Aransay AM, Marks K, Baselga J, Tabernero J, Nuciforo P, Manning BD, Marjon K, Carracedo
mTORC1-dependent AMD1 regulation sustains polyamine metabolism in prostate cancer
published pages: , ISSN: , DOI: 10.1038/nature22964
2015 Kang S, Keener AB, Jones SZ, Benschop RJ, Caro-Maldonado A, Rathmell JC, Clarke SH, Matsushima GK, Whitmire JK, Vilen BJ. J Immunol.
IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF
published pages: , ISSN: , DOI: 10.4049/jimmunol
2016 Veronica Torrano, Lorea Valcarcel-Jimenez, Ana Rosa Cortazar, Xiaojing Liu, Jelena Urosevic, Mireia Castillo-Martin, Sonia Fernández-Ruiz, Giampaolo Morciano, Alfredo Caro-Maldonado, Marc Guiu, Patricia Zúñiga-García, Mariona Graupera, Anna Bellmunt, Pahini Pandya, Mar Lorente, Natalia Martín-Martín, James David Sutherland, Pilar Sanchez-Mosquera, Laura Bozal-Basterra, Amaia Zabala-Letona, Amaia Arruabarrena-Aristorena, Antonio Berenguer, Nieves Embade, Aitziber Ugalde-Olano, Isabel Lacasa-Viscasillas, Ana Loizaga-Iriarte, Miguel Unda-Urzaiz, Nikolaus Schultz, Ana Maria Aransay, Victoria Sanz-Moreno, Rosa Barrio, Guillermo Velasco, Paolo Pinton, Carlos Cordon-Cardo, Jason W. Locasale, Roger R. Gomis, Arkaitz Carracedo
The metabolic co-regulator PGC1α suppresses prostate cancer metastasis
published pages: 645-656, ISSN: 1465-7392, DOI: 10.1038/ncb3357
Nature Cell Biology 18/6 2019-07-24
2015 Ugalde-Olano A, Egia A, Fernández-Ruiz S, Loizaga-Iriarte A4, Zuñiga-García P, Garcia S, Royo F, Lacasa-Viscasillas I, Castro E, Cortazar AR, Zabala-Letona A, Martín-Martín N, Arruabarrena-Aristorena A, Torrano-Moya V, Valcárcel-Jiménez L, Sánchez-Mosquera P, Caro-Maldonado A, González-Tampan J, Cachi-Fuentes G, Bilbao E, Montero R, Fernández S, Arrieta E, Zorroza K, Castillo-Martín M, Serra V, Salazar E, Macías-Cámara N, Tabernero J, Baselga J, Cordón-Cardo C, Aransay AM, Villar AD, Iovanna JL, Falcón-Pérez JM, Unda M, Bilbao R, Carracedo A
Methodological aspects of the molecular and histological study of prostate cancer: Focus on PTEN
published pages: , ISSN: , DOI: 10.1016/j.ymeth

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