Opendata, web and dolomites


Structural and Functional Studies of ATRX- Syndrome Protein

Total Cost €


EC-Contrib. €






 SFSASP project word cloud

Explore the words cloud of the SFSASP project. It provides you a very rough idea of what is the project "SFSASP" about.

confers    snf2    linking    techniques    works    energy    alt    atpase    nmr    remodel    localize    mental    terminal    molecular    structural    histone3    cellular    mounting    mutations    calorimetry    cancer    ray    phd    unpacked    lack    atr    varied    atrx    telomerase    remodellers    deposition    functions    genome    scattering    functional    regions    complexes    vivo    protein    maintenance    interacts    malignancies    remodelling    shown    crystallography    aging    consuming    western    links    constitutive    pathologies    lengthening    packaged    severe    dna    give    small    cryo    plant    eukaryotic    syndrome    daxx    disease    mechanism    assays    microscopy    telomere    domain    telomeres    thalassemia    combination    elucidate    interaction    linked    itself    action    isothermal    identifies    alternative    alpha    proteins    accessible    electron    helicase    interacting    homeodomain    biophysical    harbours    accompanied    rendered    despite    chromatin    heterochromatin    structure    enzymatic    pericentromeric    angle    gene    independent    family    retardation    blotting   

Project "SFSASP" data sheet

The following table provides information about the project.


Organization address
postcode: BN1 9RH

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-09-01   to  2017-08-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF SUSSEX UK (BRIGHTON) coordinator 195˙454.00


 Project objective

The eukaryotic genome is packaged into chromatin, which needs to be unpacked to provide necessary access by cellular factors for varied cellular functions. However, DNA can be rendered accessible by the action of energy-consuming chromatin remodelling proteins. One such protein is ATRX that harbours an N-terminal plant homeodomain (PHD) and a C-terminal helicase domain that confers ATPase activity and identifies ATRX as a member of the snf2 family member of chromatin remodellers. ATRX has been shown to localize in vivo with constitutive heterochromatin in pericentromeric regions as well as telomeres where it works in complex with DAXX for the deposition of the Histone3.3. Mutations in the ATRX gene give rise to ATR-X syndrome, a severe X-linked mental retardation syndrome often accompanied by alpha-thalassemia. Mounting evidence links ATRX mutations to cancer and to malignancies that depend on a telomerase-independent pathway of telomere maintenance called the ‘alternative lengthening of telomeres (ALT) pathway, linking ATRX to aging. Despite these advances however, there is lack of understanding of the molecular mechanism of ATRX and of its role within these pathologies. The proposed research aims to investigate the structural and functional properties of ATRX, and to define at a molecular level how it interacts with DAXX to remodel chromatin. We will use a combination of biophysical techniques like NMR, Isothermal Calorimetry and western blotting to characterize ATRX interaction with partner proteins. X-ray crystallography, Cryo-electron microscopy and Small angle X-ray scattering techniques will be used to elucidate the structure of ATRX complexes. We will also design assays to measure the enzymatic activity of the ATRX snf2 domain by itself and in presence of DNA and/or its interacting partners. These studies will provide insight into a potential new mechanism of chromatin remodelling and will help us elucidate the consequences of disease-related ATRX mutations.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SFSASP" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SFSASP" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NPsVLCD (2019)

Natural Product-Inspired Therapies for Leishmaniasis and Chagas Disease

Read More  


A multilinear approach to the restriction problem with applications to geometric measure theory, the Schrödinger equation and inverse problems

Read More  

MIGPSC (2018)

Shaping the European Migration Policy: the role of the security industry

Read More